NO314830B1 - Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil - Google Patents
Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil Download PDFInfo
- Publication number
- NO314830B1 NO314830B1 NO19973667A NO973667A NO314830B1 NO 314830 B1 NO314830 B1 NO 314830B1 NO 19973667 A NO19973667 A NO 19973667A NO 973667 A NO973667 A NO 973667A NO 314830 B1 NO314830 B1 NO 314830B1
- Authority
- NO
- Norway
- Prior art keywords
- carvedilol
- single unit
- administered
- pharmaceutical formulation
- patients
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- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 229940124309 non-selective beta-adrenoreceptor agonist Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000036513 peripheral conductance Effects 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 238000013310 pig model Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 235000015598 salt intake Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1995103995 DE19503995C2 (de) | 1995-02-08 | 1995-02-08 | Verwendung von Carvedilol zur Verminderung der Mortalität bei Patienten mit eingeschränkter myocardialer Funktion |
| US08/483,635 US5760069A (en) | 1995-02-08 | 1995-06-07 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| PCT/EP1996/000498 WO1996024348A2 (en) | 1995-02-08 | 1996-02-07 | Use of carbazole compounds for the treatment of congestive heart failure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO973667D0 NO973667D0 (no) | 1997-08-08 |
| NO973667L NO973667L (no) | 1997-08-08 |
| NO314830B1 true NO314830B1 (no) | 2003-06-02 |
Family
ID=26012210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19973667A NO314830B1 (no) | 1995-02-08 | 1997-08-08 | Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US5760069A (cs) |
| EP (1) | EP0808162B1 (cs) |
| JP (1) | JP3546058B2 (cs) |
| KR (1) | KR100295940B1 (cs) |
| CN (1) | CN1093760C (cs) |
| AT (1) | ATE179891T1 (cs) |
| AU (1) | AU702106C (cs) |
| BR (1) | BR9607111A (cs) |
| CA (1) | CA2212548C (cs) |
| CZ (1) | CZ292002B6 (cs) |
| DE (1) | DE69602424T2 (cs) |
| DK (1) | DK0808162T3 (cs) |
| ES (1) | ES2134588T3 (cs) |
| FI (1) | FI973255A0 (cs) |
| GR (1) | GR3030966T3 (cs) |
| HU (1) | HUP9900773A3 (cs) |
| NO (1) | NO314830B1 (cs) |
| NZ (1) | NZ301692A (cs) |
| PL (1) | PL321737A1 (cs) |
| RO (1) | RO121629B1 (cs) |
| RU (1) | RU2197242C2 (cs) |
| SI (1) | SI0808162T1 (cs) |
| SK (1) | SK106897A3 (cs) |
| UA (1) | UA55382C2 (cs) |
| WO (1) | WO1996024348A2 (cs) |
| ZA (1) | ZA96994B (cs) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760069A (en) * | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| CN1157188C (zh) * | 1996-10-09 | 2004-07-14 | 泊灵格曼海姆药品公司 | 抑制应激活化蛋白激酶的方法 |
| ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
| PL340456A1 (en) * | 1997-11-12 | 2001-02-12 | Boehringer Mannheim Pharm Corp | Novel oral dosage form of carvedilol |
| US20020054911A1 (en) * | 2000-05-11 | 2002-05-09 | Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi | Novel oral dosage form for carvedilol |
| US6664284B2 (en) | 1998-07-23 | 2003-12-16 | Roche Diagnostics Gmbh | Stabilized carvedilol injection solution |
| DE19833119A1 (de) * | 1998-07-23 | 2000-01-27 | Roche Diagnostics Gmbh | Spritzfertige Injektionslösungen enthaltend Carvedilol |
| PE20001302A1 (es) * | 1998-11-27 | 2000-11-30 | Hoffmann La Roche | Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida |
| EP1212053A4 (en) * | 1999-09-08 | 2004-08-11 | Nitromed Inc | METHODS FOR THE TREATMENT AND PROPHYLAXIS OF CONGESTIVE HEART FAILURE BY HYDRALAZIN COMPOUNDS AND ISOSORBIDE DINITRATE OR ISOSORBIDE MONONITRATE |
| AU780261B2 (en) * | 1999-10-29 | 2005-03-10 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| US7235237B2 (en) * | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| US7708989B2 (en) * | 1999-10-29 | 2010-05-04 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| US7537785B2 (en) * | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
| US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
| US6699997B2 (en) * | 2000-06-28 | 2004-03-02 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
| EP1385509A4 (en) * | 2001-04-02 | 2004-06-30 | Smithkline Beecham Corp | TREATMENT METHOD |
| WO2003028718A1 (en) * | 2001-10-01 | 2003-04-10 | Smithkline Beecham Corporation | Novel formulations of carvedilol |
| JP2005504815A (ja) * | 2001-10-02 | 2005-02-17 | スミスクライン・ビーチャム・コーポレイション | カルベジロールの新規組成物 |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| SE0103749D0 (sv) * | 2001-11-08 | 2001-11-08 | Sahltech Ab | Treatment of congestive heart failure |
| PL371409A1 (en) | 2002-01-15 | 2005-06-13 | Teva Pharmaceutical Industries Ltd. | Crystalline solids of carvedilol and processes for their preparation |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| RU2203063C1 (ru) * | 2002-03-12 | 2003-04-27 | Нестерук Владимир Викторович | Способ получения твердой лекарственной формы препарата, обладающего диуретическим действием |
| WO2003092622A2 (en) * | 2002-04-30 | 2003-11-13 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
| WO2004047724A2 (en) * | 2002-05-16 | 2004-06-10 | Genelabs Technologies, Inc | Aryl and heteroaryl compounds as antibacterial and antifungal agents |
| CA2492084A1 (en) * | 2002-06-27 | 2004-01-08 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydobromide |
| AU2003248746B2 (en) * | 2002-06-27 | 2009-01-08 | Smithkline Beecham (Cork) Limited | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
| ES2211846T3 (es) * | 2002-07-25 | 2004-07-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Uso de cilobradina o sus sales farmaceuticamente aceptables para el tratamiento o la prevencion de la insuficiencia cardiaca. |
| US6632832B1 (en) | 2002-09-10 | 2003-10-14 | Dabur Research Foundation | Anti-cancer activity of carvedilol and its isomers |
| US20050032879A1 (en) * | 2003-08-07 | 2005-02-10 | Temple Okarter | Formulations and use of a beta-blocker and an ACE-inhibitor for the treatment of cardiovascular diseases |
| JP2007512350A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール組成物の治療および送達方法 |
| US7750036B2 (en) * | 2003-11-25 | 2010-07-06 | Sb Pharmco Puerto Rico Inc. | Carvedilol salts, corresponding compositions, methods of delivery and/or treatment |
| US8734850B2 (en) * | 2003-11-25 | 2014-05-27 | Flamel Technologies | Oral medicinal product with modified release of at least one active principle in multimicrocapsular form |
| EP1778267A4 (en) * | 2004-07-16 | 2010-01-06 | Nitromed Inc | COMPOSITIONS AND METHODS RELATED TO HEART ERROR |
| WO2006135757A1 (en) * | 2005-06-09 | 2006-12-21 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of carvedilol and processes for their preparation |
| WO2007097951A2 (en) * | 2006-02-17 | 2007-08-30 | Nitromed, Inc. | Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
| US8367112B2 (en) * | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
| US8703804B2 (en) * | 2006-03-26 | 2014-04-22 | Uti Limited Partnership | Ryanodine receptor inhibitors and methods relating thereto |
| WO2007136626A1 (en) * | 2006-05-16 | 2007-11-29 | Nitromed, Inc. | Solid dosage formulations of hydralazine compounds |
| EP1991527A2 (en) * | 2006-06-28 | 2008-11-19 | Teva Pharmaceutical Industries Ltd | Polymorphous forms of carvedilol phosphate |
| EP2114881A1 (en) * | 2007-02-26 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Process for the purification of carvedilol or its salts thereof |
| US20090076116A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched carvediolo |
| JP5651586B2 (ja) | 2008-05-16 | 2015-01-14 | コーセラ，インコーポレーテッド | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
| EP2558437B1 (en) | 2010-04-12 | 2015-08-05 | Supernus Pharmaceuticals, Inc. | Methods for producing viloxazine salts and novel polymorphs thereof |
| MX2014001556A (es) | 2011-08-12 | 2014-03-31 | Boehringer Ingelheim Vetmed | Composicion farmaceutica de sabor enmascarado. |
| EP3468539A4 (en) * | 2016-06-13 | 2020-01-15 | Ascendia Pharmaceuticals, LLC | PARENTERAL ADMINISTRATION WITH DELAYED RELEASE OF CARVEDILOL DISPERSION SYSTEMS |
| US10772869B1 (en) | 2019-07-24 | 2020-09-15 | ECI Pharmaceuticals, LLC | Pharmaceutical compositions including carvedilol and methods of using the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3319027A1 (de) | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
| SE460945B (sv) * | 1987-01-15 | 1989-12-11 | Lejus Medical Ab | En multipel-unit-dos komposition av furosemid |
| RU2058144C1 (ru) * | 1988-12-15 | 1996-04-20 | Центр по химии лекарственных средств | Средство для лечения сердечной недостаточности |
| US5312828A (en) * | 1989-06-14 | 1994-05-17 | Finkelstein Joseph A | Substituted imidazoles having angiotensin II receptor blocking activity |
| US5225401A (en) * | 1991-08-12 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Treatment of congestive heart failure |
| RU2032685C1 (ru) * | 1991-12-16 | 1995-04-10 | Центр по химии лекарственных средств | Производные пиридо (3,2-а)карбазола, обладающие кардиотонической активностью |
| US5308862A (en) * | 1993-03-05 | 1994-05-03 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
-
1995
- 1995-06-07 US US08/483,635 patent/US5760069A/en not_active Ceased
-
1996
- 1996-02-07 DK DK96902984T patent/DK0808162T3/da active
- 1996-02-07 BR BR9607111A patent/BR9607111A/pt not_active Application Discontinuation
- 1996-02-07 HU HU9900773A patent/HUP9900773A3/hu unknown
- 1996-02-07 AT AT96902984T patent/ATE179891T1/de not_active IP Right Cessation
- 1996-02-07 US US08/875,603 patent/US5902821A/en not_active Ceased
- 1996-02-07 US US10/721,022 patent/USRE40707E1/en not_active Expired - Lifetime
- 1996-02-07 DE DE69602424T patent/DE69602424T2/de not_active Ceased
- 1996-02-07 CN CN96192902A patent/CN1093760C/zh not_active Expired - Fee Related
- 1996-02-07 CA CA002212548A patent/CA2212548C/en not_active Expired - Fee Related
- 1996-02-07 JP JP52398296A patent/JP3546058B2/ja not_active Expired - Lifetime
- 1996-02-07 KR KR1019970705480A patent/KR100295940B1/ko not_active Expired - Lifetime
- 1996-02-07 AU AU47181/96A patent/AU702106C/en not_active Revoked
- 1996-02-07 WO PCT/EP1996/000498 patent/WO1996024348A2/en not_active Ceased
- 1996-02-07 PL PL96321737A patent/PL321737A1/xx unknown
- 1996-02-07 SI SI9630081T patent/SI0808162T1/xx not_active IP Right Cessation
- 1996-02-07 EP EP96902984A patent/EP0808162B1/en not_active Expired - Lifetime
- 1996-02-07 NZ NZ301692A patent/NZ301692A/xx not_active IP Right Cessation
- 1996-02-07 RU RU97114836/14A patent/RU2197242C2/ru not_active IP Right Cessation
- 1996-02-07 SK SK1068-97A patent/SK106897A3/sk unknown
- 1996-02-07 ES ES96902984T patent/ES2134588T3/es not_active Expired - Lifetime
- 1996-02-07 RO RO97-01454A patent/RO121629B1/ro unknown
- 1996-02-07 CZ CZ19972463A patent/CZ292002B6/cs not_active IP Right Cessation
- 1996-02-08 ZA ZA9600994A patent/ZA96994B/xx unknown
- 1996-07-02 UA UA97094498A patent/UA55382C2/uk unknown
-
1997
- 1997-08-07 FI FI973255A patent/FI973255A0/fi unknown
- 1997-08-08 NO NO19973667A patent/NO314830B1/no not_active IP Right Cessation
-
1999
- 1999-08-11 GR GR990402047T patent/GR3030966T3/el unknown
-
2001
- 2001-05-23 US US09/863,535 patent/US20010044455A1/en not_active Abandoned
-
2002
- 2002-12-19 US US10/324,856 patent/US20030105138A1/en not_active Abandoned
-
2003
- 2003-11-25 US US10/721,020 patent/USRE40000E1/en not_active Expired - Lifetime
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