NO314584B1 - Purinderivater og deres anvendelse til fremstilling av antikoagulanter - Google Patents
Purinderivater og deres anvendelse til fremstilling av antikoagulanter Download PDFInfo
- Publication number
- NO314584B1 NO314584B1 NO19990673A NO990673A NO314584B1 NO 314584 B1 NO314584 B1 NO 314584B1 NO 19990673 A NO19990673 A NO 19990673A NO 990673 A NO990673 A NO 990673A NO 314584 B1 NO314584 B1 NO 314584B1
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- formula
- compound
- compounds
- alkyl
- hydrogen
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- 238000002360 preparation method Methods 0.000 title claims description 24
- 239000003146 anticoagulant agent Substances 0.000 title abstract description 7
- 229940127219 anticoagulant drug Drugs 0.000 title abstract description 7
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract description 3
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- 150000001875 compounds Chemical class 0.000 claims abstract description 195
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 20
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/689,979 US5753635A (en) | 1996-08-16 | 1996-08-16 | Purine derivatives and their use as anti-coagulants |
| PCT/EP1997/004445 WO1998007725A1 (en) | 1996-08-16 | 1997-08-14 | Purine derivatives and their use as anti-coagulants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO990673D0 NO990673D0 (no) | 1999-02-12 |
| NO990673L NO990673L (no) | 1999-04-15 |
| NO314584B1 true NO314584B1 (no) | 2003-04-14 |
Family
ID=24770610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19990673A NO314584B1 (no) | 1996-08-16 | 1999-02-12 | Purinderivater og deres anvendelse til fremstilling av antikoagulanter |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5753635A (es) |
| EP (1) | EP0920430B1 (es) |
| JP (1) | JP2000516242A (es) |
| KR (1) | KR20000068177A (es) |
| CN (1) | CN1096461C (es) |
| AT (1) | ATE250606T1 (es) |
| AU (1) | AU722631B2 (es) |
| CA (1) | CA2262876A1 (es) |
| CZ (1) | CZ50299A3 (es) |
| DE (1) | DE69725151T2 (es) |
| DK (1) | DK0920430T3 (es) |
| ES (1) | ES2206746T3 (es) |
| HK (1) | HK1020057A1 (es) |
| HU (1) | HUP9902308A3 (es) |
| IL (1) | IL128160A (es) |
| NO (1) | NO314584B1 (es) |
| NZ (1) | NZ333895A (es) |
| PL (1) | PL331608A1 (es) |
| PT (1) | PT920430E (es) |
| RU (1) | RU2191778C2 (es) |
| SK (1) | SK19399A3 (es) |
| UA (1) | UA57746C2 (es) |
| WO (1) | WO1998007725A1 (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2214685C (en) | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
| ES2196181T3 (es) | 1995-11-01 | 2003-12-16 | Novartis Ag | Derivados de purina y proceso para su preparacion. |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| ZA971896B (en) * | 1996-03-26 | 1998-09-07 | Du Pont Merck Pharma | Aryloxy-and arythio-fused pyridines and pyrimidines and derivatives |
| PT929547E (pt) | 1996-09-12 | 2003-03-31 | Schering Ag | Derivados da benzamidina substituidos por derivados de aminoacidos ciclicos e de hidroxiacidos ciclicos e seu uso como anticoagulantes |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| PL341044A1 (en) | 1997-12-19 | 2001-03-26 | Schering Ag | Derivatives of orthoantranilic amide as anticoagulants |
| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| US6127376A (en) | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
| CA2320730A1 (en) | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
| GB9903762D0 (en) | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| MEP59808A (en) * | 2001-02-24 | 2011-05-10 | Boehringer Ingelheim Pharma | Xanthine derivative, production and use thereof as a medicament |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| AU2002351412B2 (en) | 2001-12-21 | 2010-05-20 | Exelixis Patent Company Llc | Modulators of LXR |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| US7407955B2 (en) * | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7495005B2 (en) * | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
| US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| US7482337B2 (en) * | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| DE10254304A1 (de) * | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
| US7566707B2 (en) | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
| DE10355304A1 (de) * | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004009039A1 (de) | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
| US7393847B2 (en) * | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
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| JPS5922697B2 (ja) * | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
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| DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| JPH08504769A (ja) * | 1992-12-15 | 1996-05-21 | コルバス・インターナショナル、インコーポレイテッド | 因子Ｘａの新規インヒビター |
| US5332822A (en) * | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
| DE69419141D1 (de) * | 1993-02-12 | 1999-07-22 | Corvas Int Inc | Inhibitoren gegen thrombose |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
-
1996
- 1996-08-16 US US08/689,979 patent/US5753635A/en not_active Expired - Fee Related
-
1997
- 1997-08-14 EP EP97938904A patent/EP0920430B1/en not_active Expired - Lifetime
- 1997-08-14 PT PT97938904T patent/PT920430E/pt unknown
- 1997-08-14 CZ CZ99502A patent/CZ50299A3/cs unknown
- 1997-08-14 CA CA002262876A patent/CA2262876A1/en not_active Abandoned
- 1997-08-14 KR KR1019997001289A patent/KR20000068177A/ko not_active Application Discontinuation
- 1997-08-14 JP JP10510377A patent/JP2000516242A/ja not_active Ceased
- 1997-08-14 WO PCT/EP1997/004445 patent/WO1998007725A1/en not_active Application Discontinuation
- 1997-08-14 RU RU99105119/04A patent/RU2191778C2/ru not_active IP Right Cessation
- 1997-08-14 DE DE69725151T patent/DE69725151T2/de not_active Expired - Fee Related
- 1997-08-14 HU HU9902308A patent/HUP9902308A3/hu unknown
- 1997-08-14 IL IL12816097A patent/IL128160A/xx not_active IP Right Cessation
- 1997-08-14 ES ES97938904T patent/ES2206746T3/es not_active Expired - Lifetime
- 1997-08-14 UA UA99031393A patent/UA57746C2/uk unknown
- 1997-08-14 NZ NZ333895A patent/NZ333895A/xx unknown
- 1997-08-14 SK SK193-99A patent/SK19399A3/sk unknown
- 1997-08-14 PL PL97331608A patent/PL331608A1/xx unknown
- 1997-08-14 DK DK97938904T patent/DK0920430T3/da active
- 1997-08-14 AU AU41186/97A patent/AU722631B2/en not_active Ceased
- 1997-08-14 CN CN97197270A patent/CN1096461C/zh not_active Expired - Fee Related
- 1997-08-14 AT AT97938904T patent/ATE250606T1/de not_active IP Right Cessation
-
1999
- 1999-02-12 NO NO19990673A patent/NO314584B1/no not_active IP Right Cessation
- 1999-11-18 HK HK99105313A patent/HK1020057A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU722631B2 (en) | 2000-08-10 |
| UA57746C2 (uk) | 2003-07-15 |
| WO1998007725A1 (en) | 1998-02-26 |
| RU2191778C2 (ru) | 2002-10-27 |
| US5753635A (en) | 1998-05-19 |
| HUP9902308A2 (en) | 2000-07-28 |
| EP0920430A1 (en) | 1999-06-09 |
| NO990673L (no) | 1999-04-15 |
| ES2206746T3 (es) | 2004-05-16 |
| HK1020057A1 (en) | 2000-03-10 |
| KR20000068177A (ko) | 2000-11-25 |
| IL128160A0 (en) | 1999-11-30 |
| CN1096461C (zh) | 2002-12-18 |
| PL331608A1 (en) | 1999-08-02 |
| HUP9902308A3 (en) | 2000-08-28 |
| ATE250606T1 (de) | 2003-10-15 |
| CZ50299A3 (cs) | 1999-06-16 |
| NZ333895A (en) | 2000-07-28 |
| PT920430E (pt) | 2003-12-31 |
| SK19399A3 (en) | 1999-08-06 |
| DE69725151T2 (de) | 2004-06-09 |
| EP0920430B1 (en) | 2003-09-24 |
| DK0920430T3 (da) | 2003-11-17 |
| AU4118697A (en) | 1998-03-06 |
| DE69725151D1 (de) | 2003-10-30 |
| IL128160A (en) | 2003-04-10 |
| NO990673D0 (no) | 1999-02-12 |
| JP2000516242A (ja) | 2000-12-05 |
| CA2262876A1 (en) | 1998-02-26 |
| CN1228092A (zh) | 1999-09-08 |
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