NO311637B1 - Topiske oftalmiske formuleringer inneholdende doxepinderivater for behandling av öyenallergisykdommer - Google Patents
Topiske oftalmiske formuleringer inneholdende doxepinderivater for behandling av öyenallergisykdommer Download PDFInfo
- Publication number
- NO311637B1 NO311637B1 NO19970517A NO970517A NO311637B1 NO 311637 B1 NO311637 B1 NO 311637B1 NO 19970517 A NO19970517 A NO 19970517A NO 970517 A NO970517 A NO 970517A NO 311637 B1 NO311637 B1 NO 311637B1
- Authority
- NO
- Norway
- Prior art keywords
- dimethylaminopropylidene
- dihydrodibenz
- oxepin
- acetic acid
- treatment
- Prior art date
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000580 secretagogue effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/469,729 US5641805A (en) | 1995-06-06 | 1995-06-06 | Topical ophthalmic formulations for treating allergic eye diseases |
| PCT/US1996/006289 WO1996039147A2 (en) | 1995-06-06 | 1996-05-03 | Topical ophthalmic formulations containing doxepin derivatives for treating allergic eye diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO970517D0 NO970517D0 (no) | 1997-02-05 |
| NO970517L NO970517L (no) | 1997-04-03 |
| NO311637B1 true NO311637B1 (no) | 2001-12-27 |
Family
ID=23864859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19970517A NO311637B1 (no) | 1995-06-06 | 1997-02-05 | Topiske oftalmiske formuleringer inneholdende doxepinderivater for behandling av öyenallergisykdommer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5641805A (pt) |
| EP (1) | EP0799044B1 (pt) |
| JP (1) | JP3068858B2 (pt) |
| KR (1) | KR100202155B1 (pt) |
| CN (1) | CN1082367C (pt) |
| AT (1) | ATE220906T1 (pt) |
| AU (1) | AU698854B2 (pt) |
| CA (1) | CA2195094C (pt) |
| DE (2) | DE10299034I2 (pt) |
| DK (1) | DK0799044T3 (pt) |
| ES (1) | ES2179198T3 (pt) |
| FI (1) | FI970489A0 (pt) |
| LU (1) | LU90969I2 (pt) |
| MX (1) | MX9701013A (pt) |
| MY (1) | MY116651A (pt) |
| NL (1) | NL300101I2 (pt) |
| NO (1) | NO311637B1 (pt) |
| PT (1) | PT799044E (pt) |
| TW (1) | TW438588B (pt) |
| WO (1) | WO1996039147A2 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859000A (en) * | 1995-06-07 | 1999-01-12 | University Of Utah Research Foundation | Method for reducing mast cell mediated allergic reactions |
| JP2002520355A (ja) * | 1998-07-14 | 2002-07-09 | アルコン ラボラトリーズ， インコーポレイテッド | 非アレルギー性眼炎症障害を処置および眼新生血管形成を予防する医薬製造のための、１１−（３−ジメチルアミノプロピリデン）−６，１１−ジヒドロジベンズ［ｂ，ｅ］オキセピン−２−酢酸の使用 |
| US6174914B1 (en) | 1999-06-15 | 2001-01-16 | Alcon Laboratories, Inc. | Method of inhibiting cytokine release from human ocular cells |
| JP4851035B2 (ja) | 1999-06-18 | 2012-01-11 | アルコン ラボラトリーズ，インコーポレイティド | アレルギー性眼疾患を処置するための局所的な眼マスト細胞安定剤 |
| DE60109742T2 (de) | 2000-01-25 | 2005-08-18 | Alcon Inc. | Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen |
| PT1289945E (pt) | 2000-05-19 | 2004-10-29 | Alcon Inc | Derivados dissulfureto de anilina para o tratamento de doencas alergicas |
| AU5567501A (en) | 2000-05-19 | 2001-12-03 | Alcon Universal Ltd | Disulfide derivatives useful for treating allergic diseases |
| EP1284722B1 (en) | 2000-05-19 | 2005-08-24 | Alcon Inc. | Compositions containing a benzamide disulfide derivative for treating allergic diseases |
| AU2002316887A1 (en) * | 2001-05-03 | 2002-11-18 | Novartis Ag | Anti-ige antibody to treat ocular allergies |
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| US7977376B2 (en) | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
| PL369630A1 (en) * | 2001-12-05 | 2005-05-02 | Alcon, Inc. | Use of a h1 antagonist and rimexolone as a safe steroid to treat rhinitis |
| US20050209312A1 (en) * | 2004-03-19 | 2005-09-22 | Bausch & Lomb Incorporated | Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative |
| AU2005259911A1 (en) * | 2004-06-28 | 2006-01-12 | Alcon, Inc. | Topical formulations for treating allergic diseases |
| US20060110328A1 (en) * | 2004-11-24 | 2006-05-25 | Cagle Gerald D | Method of delivering nasal spray |
| CN101217937A (zh) * | 2005-07-08 | 2008-07-09 | 千寿制药株式会社 | 包含奥洛他定的透皮吸收眼科制剂 |
| EA016221B1 (ru) | 2006-03-31 | 2012-03-30 | ВИСТЭКОН ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Офтальмические композиции и способ лечения аллергических заболеваний глаз |
| US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
| EP2977042B1 (en) | 2007-02-07 | 2020-01-01 | Novartis AG | Olopatadine formulations for topical nasal administration |
| CA2682730A1 (en) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| EP2189157A4 (en) * | 2007-09-06 | 2012-10-31 | Kyowa Hakko Kirin Co Ltd | EYE DROPPING WITH DIBENZO [b, e] OXEPINE DERIVATIVE |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| IT1397503B1 (it) | 2009-04-21 | 2013-01-16 | F S I Fabbrica Italiana Sint | Processo per la preparazione di olopatadina |
| CN104173273A (zh) | 2009-07-17 | 2014-12-03 | 爱尔康研究有限公司 | 儿童用奥洛他定鼻腔喷雾方案 |
| WO2011027322A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Extended release dosage form containing olopatadine for oral administration |
| BR112012007091A2 (pt) * | 2009-10-01 | 2016-04-19 | Alcon Res Ltd | composições de olopatadina e seus usos |
| TW201206936A (en) | 2010-07-19 | 2012-02-16 | Alcon Res Ltd | Methods and compositions for the treatment of allergy |
| TWI544922B (zh) * | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| CN103202833A (zh) * | 2012-12-25 | 2013-07-17 | 常州市亚邦医药研究所有限公司 | 一种奥洛他定或其盐的药用组合物及其制备方法 |
| CA2929074A1 (en) * | 2013-10-31 | 2015-05-07 | Nephron Pharmaceuticals Corporation | Formulation of olopatadine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4370324A (en) * | 1980-09-17 | 1983-01-25 | Bernstein Joel E | Method and composition for treating and preventing irritation of the eyes |
| GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| US4923892A (en) * | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
-
1995
- 1995-06-06 US US08/469,729 patent/US5641805A/en not_active Expired - Lifetime
-
1996
- 1996-05-03 AU AU57261/96A patent/AU698854B2/en not_active Expired
- 1996-05-03 DE DE2002199034 patent/DE10299034I2/de active Active
- 1996-05-03 DK DK96915500T patent/DK0799044T3/da active
- 1996-05-03 EP EP96915500A patent/EP0799044B1/en not_active Expired - Lifetime
- 1996-05-03 CA CA002195094A patent/CA2195094C/en not_active Expired - Lifetime
- 1996-05-03 KR KR1019970700721A patent/KR100202155B1/ko active IP Right Review Request
- 1996-05-03 WO PCT/US1996/006289 patent/WO1996039147A2/en active IP Right Grant
- 1996-05-03 PT PT96915500T patent/PT799044E/pt unknown
- 1996-05-03 MX MX9701013A patent/MX9701013A/es unknown
- 1996-05-03 AT AT96915500T patent/ATE220906T1/de active
- 1996-05-03 JP JP9500510A patent/JP3068858B2/ja not_active Expired - Lifetime
- 1996-05-03 CN CN96190605A patent/CN1082367C/zh not_active Ceased
- 1996-05-03 DE DE69622527T patent/DE69622527T2/de not_active Expired - Lifetime
- 1996-05-03 ES ES96915500T patent/ES2179198T3/es not_active Expired - Lifetime
- 1996-05-14 MY MYPI96001818A patent/MY116651A/en unknown
- 1996-06-04 TW TW085106668A patent/TW438588B/zh not_active IP Right Cessation
-
1997
- 1997-02-05 NO NO19970517A patent/NO311637B1/no not_active IP Right Cessation
- 1997-02-05 FI FI970489A patent/FI970489A0/fi unknown
-
2002
- 2002-09-19 NL NL300101C patent/NL300101I2/nl unknown
- 2002-10-02 LU LU90969C patent/LU90969I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5641805A (en) | 1997-06-24 |
| TW438588B (en) | 2001-06-07 |
| ES2179198T3 (es) | 2003-01-16 |
| NL300101I2 (nl) | 2003-01-06 |
| JPH09510235A (ja) | 1997-10-14 |
| CA2195094C (en) | 2002-02-26 |
| ATE220906T1 (de) | 2002-08-15 |
| CN1082367C (zh) | 2002-04-10 |
| NO970517D0 (no) | 1997-02-05 |
| DE69622527D1 (de) | 2002-08-29 |
| EP0799044B1 (en) | 2002-07-24 |
| WO1996039147A2 (en) | 1996-12-12 |
| KR100202155B1 (ko) | 1999-06-15 |
| MX9701013A (es) | 1997-05-31 |
| FI970489A (fi) | 1997-02-05 |
| MY116651A (en) | 2004-03-31 |
| DK0799044T3 (da) | 2002-10-14 |
| KR970704452A (ko) | 1997-09-06 |
| AU5726196A (en) | 1996-12-24 |
| NL300101I1 (nl) | 2002-12-02 |
| WO1996039147A3 (en) | 1997-02-20 |
| DE69622527T2 (de) | 2002-12-05 |
| JP3068858B2 (ja) | 2000-07-24 |
| AU698854B2 (en) | 1998-11-12 |
| FI970489A0 (fi) | 1997-02-05 |
| PT799044E (pt) | 2002-11-29 |
| DE10299034I1 (de) | 2003-01-23 |
| NO970517L (no) | 1997-04-03 |
| DE10299034I2 (de) | 2005-07-07 |
| EP0799044A2 (en) | 1997-10-08 |
| CN1161000A (zh) | 1997-10-01 |
| LU90969I2 (fr) | 2002-12-02 |
| CA2195094A1 (en) | 1996-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |