NO310230B1 - N-(aroyl)glycin-hydroksaminsyre-derivater og farmasöytiske blandinger inneholdende dem - Google Patents
N-(aroyl)glycin-hydroksaminsyre-derivater og farmasöytiske blandinger inneholdende dem Download PDFInfo
- Publication number
- NO310230B1 NO310230B1 NO19980313A NO980313A NO310230B1 NO 310230 B1 NO310230 B1 NO 310230B1 NO 19980313 A NO19980313 A NO 19980313A NO 980313 A NO980313 A NO 980313A NO 310230 B1 NO310230 B1 NO 310230B1
- Authority
- NO
- Norway
- Prior art keywords
- acid
- cyclopentyloxy
- compound according
- methoxy
- benzoyl
- Prior art date
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- 206010003246 arthritis Diseases 0.000 claims abstract description 5
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- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 19
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- 239000001257 hydrogen Substances 0.000 claims description 10
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- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 2
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US152495P | 1995-07-26 | 1995-07-26 | |
| PCT/IB1996/000451 WO1997005105A1 (en) | 1995-07-26 | 1996-05-14 | N-(aroyl)glycine hydroxamic acid derivatives and related compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO980313D0 NO980313D0 (no) | 1998-01-23 |
| NO980313L NO980313L (no) | 1998-03-23 |
| NO310230B1 true NO310230B1 (no) | 2001-06-11 |
Family
ID=21696482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19980313A NO310230B1 (no) | 1995-07-26 | 1998-01-23 | N-(aroyl)glycin-hydroksaminsyre-derivater og farmasöytiske blandinger inneholdende dem |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6225351B1 (ja) |
| EP (1) | EP0850215B1 (ja) |
| JP (1) | JP3131225B2 (ja) |
| KR (1) | KR100332273B1 (ja) |
| CN (1) | CN1090614C (ja) |
| AT (1) | ATE197038T1 (ja) |
| AU (1) | AU711755B2 (ja) |
| CA (1) | CA2227237C (ja) |
| DE (1) | DE69610709T2 (ja) |
| DK (1) | DK0850215T3 (ja) |
| ES (1) | ES2151156T3 (ja) |
| GR (1) | GR3034969T3 (ja) |
| HK (1) | HK1018047A1 (ja) |
| IL (1) | IL118889A (ja) |
| MX (1) | MX9800710A (ja) |
| NO (1) | NO310230B1 (ja) |
| NZ (1) | NZ305940A (ja) |
| PT (1) | PT850215E (ja) |
| TW (1) | TW401389B (ja) |
| WO (1) | WO1997005105A1 (ja) |
| ZA (1) | ZA966314B (ja) |
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| US5698579A (en) * | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
| US5801195A (en) * | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
| US5728845A (en) | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic nitriles |
| KR19990001101A (ko) * | 1997-06-12 | 1999-01-15 | 손경식 | 캐테콜 아미노산 유도체, 이의 제조방법 및 그를 함유한 약제 조성물 |
| CN1265590A (zh) | 1997-07-31 | 2000-09-06 | 赛尔金有限公司 | 取代的链烷异羟肟酸及降低肿瘤坏死因子α水平的方法 |
| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| ATE320800T1 (de) | 1999-08-21 | 2006-04-15 | Altana Pharma Ag | Synergistische kombination von roflumilast und salmeterol |
| US6667316B1 (en) | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US6326388B1 (en) | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
| US6699899B1 (en) | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| US8030343B2 (en) | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| IT1317049B1 (it) | 2000-06-23 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
| JP4617449B2 (ja) * | 2002-07-11 | 2011-01-26 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するｎ−ヒドロキシアミド誘導体 |
| ES2552247T3 (es) | 2003-01-08 | 2015-11-26 | The University Of Washington | Agentes antibacterianos |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US8088804B2 (en) | 2005-12-15 | 2012-01-03 | Pfizer Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
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| US3732295A (en) * | 1969-11-25 | 1973-05-08 | Dompe Farmaceutici Spa | Trimethoxybenzoyl-aminoalkanoic acids |
| US3692827A (en) * | 1970-06-26 | 1972-09-19 | Inst Chemioterapico Italiano S | Derivatives of aminoalkanoic acids |
| GB1418595A (en) * | 1973-02-14 | 1975-12-24 | Ss Pharmaceutical Co | N- 2-alkoxybenzoyl- amino acids and a process for producing the same |
| US4193926A (en) | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| US4728670A (en) | 1986-06-04 | 1988-03-01 | E. R. Squibb & Sons, Inc. | Biphenyl hydroxamic acids |
| CA1316935C (en) | 1987-12-09 | 1993-04-27 | Hiromitsu Saito | Hydroxamic acid derivatives |
| DE3823299A1 (de) | 1988-07-07 | 1990-01-11 | Schering Ag | Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln |
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-
1996
- 1996-05-14 AT AT96911095T patent/ATE197038T1/de not_active IP Right Cessation
- 1996-05-14 NZ NZ305940A patent/NZ305940A/xx unknown
- 1996-05-14 JP JP09507392A patent/JP3131225B2/ja not_active Expired - Fee Related
- 1996-05-14 MX MX9800710A patent/MX9800710A/es not_active IP Right Cessation
- 1996-05-14 ES ES96911095T patent/ES2151156T3/es not_active Expired - Lifetime
- 1996-05-14 US US09/011,462 patent/US6225351B1/en not_active Expired - Fee Related
- 1996-05-14 CN CN96195846A patent/CN1090614C/zh not_active Expired - Fee Related
- 1996-05-14 KR KR1019980700531A patent/KR100332273B1/ko not_active IP Right Cessation
- 1996-05-14 WO PCT/IB1996/000451 patent/WO1997005105A1/en active IP Right Grant
- 1996-05-14 DE DE69610709T patent/DE69610709T2/de not_active Expired - Fee Related
- 1996-05-14 CA CA002227237A patent/CA2227237C/en not_active Expired - Fee Related
- 1996-05-14 PT PT96911095T patent/PT850215E/pt unknown
- 1996-05-14 DK DK96911095T patent/DK0850215T3/da active
- 1996-05-14 EP EP96911095A patent/EP0850215B1/en not_active Expired - Lifetime
- 1996-05-14 AU AU54079/96A patent/AU711755B2/en not_active Ceased
- 1996-05-16 TW TW085105815A patent/TW401389B/zh not_active IP Right Cessation
- 1996-07-18 IL IL11888996A patent/IL118889A/xx not_active IP Right Cessation
- 1996-07-25 ZA ZA9606314A patent/ZA966314B/xx unknown
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1998
- 1998-01-23 NO NO19980313A patent/NO310230B1/no not_active Application Discontinuation
- 1998-12-02 HK HK98112662A patent/HK1018047A1/xx not_active IP Right Cessation
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2000
- 2000-11-30 GR GR20000402672T patent/GR3034969T3/el not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| JPH10511695A (ja) | 1998-11-10 |
| US20020055543A1 (en) | 2002-05-09 |
| CN1090614C (zh) | 2002-09-11 |
| CA2227237C (en) | 2005-12-13 |
| ES2151156T3 (es) | 2000-12-16 |
| KR19990035870A (ko) | 1999-05-25 |
| NZ305940A (en) | 1999-05-28 |
| US6225351B1 (en) | 2001-05-01 |
| DK0850215T3 (da) | 2000-11-20 |
| ZA966314B (en) | 1998-01-26 |
| DE69610709D1 (de) | 2000-11-23 |
| IL118889A0 (en) | 1996-10-31 |
| KR100332273B1 (ko) | 2002-06-20 |
| NO980313L (no) | 1998-03-23 |
| MX9800710A (es) | 1998-04-30 |
| CN1192201A (zh) | 1998-09-02 |
| WO1997005105A1 (en) | 1997-02-13 |
| PT850215E (pt) | 2001-03-30 |
| JP3131225B2 (ja) | 2001-01-31 |
| IL118889A (en) | 2003-12-10 |
| EP0850215B1 (en) | 2000-10-18 |
| TW401389B (en) | 2000-08-11 |
| DE69610709T2 (de) | 2001-02-22 |
| AU711755B2 (en) | 1999-10-21 |
| AU5407996A (en) | 1997-02-26 |
| GR3034969T3 (en) | 2001-02-28 |
| CA2227237A1 (en) | 1997-02-13 |
| ATE197038T1 (de) | 2000-11-15 |
| EP0850215A1 (en) | 1998-07-01 |
| NO980313D0 (no) | 1998-01-23 |
| HK1018047A1 (en) | 1999-12-10 |
| US6384236B1 (en) | 2002-05-07 |
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