NO309901B1 - FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon - Google Patents

FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon Download PDF

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Publication number
NO309901B1
NO309901B1 NO982716A NO982716A NO309901B1 NO 309901 B1 NO309901 B1 NO 309901B1 NO 982716 A NO982716 A NO 982716A NO 982716 A NO982716 A NO 982716A NO 309901 B1 NO309901 B1 NO 309901B1
Authority
NO
Norway
Prior art keywords
group
formula
alkyl
iodine
hydrogen
Prior art date
Application number
NO982716A
Other languages
English (en)
Norwegian (no)
Other versions
NO982716L (no
NO982716D0 (no
Inventor
Tarek Mansour
Alex Cimpoia
Krzystof Bednarski
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of NO982716L publication Critical patent/NO982716L/no
Publication of NO982716D0 publication Critical patent/NO982716D0/no
Publication of NO309901B1 publication Critical patent/NO309901B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO982716A 1995-12-14 1998-06-12 FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon NO309901B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
PCT/CA1996/000845 WO1997021706A1 (en) 1995-12-14 1996-12-13 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (3)

Publication Number Publication Date
NO982716L NO982716L (no) 1998-06-12
NO982716D0 NO982716D0 (no) 1998-06-12
NO309901B1 true NO309901B1 (no) 2001-04-17

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982716A NO309901B1 (no) 1995-12-14 1998-06-12 FremgangsmÕte for syntese av dioksalan-nukleotider med <beta>- konfigurasjon

Country Status (27)

Country Link
US (4) US5922867A (Direct)
EP (1) EP0970074B1 (Direct)
JP (1) JP3229990B2 (Direct)
KR (1) KR100406159B1 (Direct)
CN (1) CN1080263C (Direct)
AP (1) AP879A (Direct)
AT (1) ATE214699T1 (Direct)
AU (1) AU706328B2 (Direct)
BR (1) BR9612351A (Direct)
CA (1) CA2237730C (Direct)
DE (1) DE69620042T2 (Direct)
DK (1) DK0970074T3 (Direct)
EA (1) EA000844B1 (Direct)
ES (1) ES2172697T3 (Direct)
GB (1) GB9525606D0 (Direct)
HU (1) HU224076B1 (Direct)
IL (3) IL144155A (Direct)
IN (1) IN187349B (Direct)
MX (1) MX9804701A (Direct)
NO (1) NO309901B1 (Direct)
NZ (1) NZ323855A (Direct)
OA (1) OA11094A (Direct)
PL (1) PL188447B1 (Direct)
PT (1) PT970074E (Direct)
TW (1) TW341574B (Direct)
WO (1) WO1997021706A1 (Direct)
ZA (1) ZA9610544B (Direct)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2285577A1 (en) 1997-04-07 1998-10-15 Triangle Pharmaceuticals, Inc. Compositions containing mkc-442 in combination with other antiviral agents
CA2563022C (en) 1998-08-12 2010-11-23 Gilead Sciences, Inc. Process for preparing 1,3-dioxolane derivatives
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
KR100653485B1 (ko) * 1998-12-23 2006-12-04 샤이어 바이오켐 인코포레이티드 항바이러스성 뉴클레오시드 유도체
JP2002538780A (ja) * 1999-02-11 2002-11-19 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
ES2218216T3 (es) * 1999-09-24 2004-11-16 Shire Biochem Inc. Analogos de nucleosidos de dioxolano para el tratamiento o la prevencion de infecciones viricas.
WO2001032153A2 (en) * 1999-11-04 2001-05-10 Shire Biochem Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
BR0104461A (pt) * 2000-02-10 2002-08-06 Mitsui Chemicals Inc Processo seletivo para produzir um anÈmero a partir de um derivado de sacarìdeo 1-fosforilado e processo para produzir um nucleosìdeo
JP2003522769A (ja) * 2000-02-11 2003-07-29 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
KR20040002871A (ko) 2001-03-01 2004-01-07 트라이앵글 파마슈티칼스 인코포레이티드 시스-ｆｔｃ의 다형 및 기타 결정형
WO2003020222A2 (en) * 2001-09-04 2003-03-13 Merck & Co., Inc. PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
WO2003037344A1 (en) * 2001-11-02 2003-05-08 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
AU2002365234B2 (en) * 2001-12-14 2009-01-29 Pharmasset Inc N4-acylcytosine nucleosides for treatment of viral infections
AU2003236757B2 (en) 2002-01-25 2009-12-03 Takeda Pharmaceutical Company Limited Process for producing dioxolane nucleoside analogues
BR0313302A (pt) 2002-08-06 2005-06-28 Pharmasset Inc Processos para a preparação de nucleosìdeos de 1,3-dioxolano
US7524910B2 (en) 2002-10-15 2009-04-28 Exxonmobil Chemical Patents Inc. Polyolefin adhesive compositions and articles made therefrom
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
CA2554782C (en) * 2004-02-03 2013-08-13 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process

Also Published As

Publication number Publication date
DE69620042T2 (de) 2002-10-17
DK0970074T3 (da) 2002-07-15
ES2172697T3 (es) 2002-10-01
CN1080263C (zh) 2002-03-06
KR100406159B1 (ko) 2004-11-16
ATE214699T1 (de) 2002-04-15
CA2237730C (en) 2001-12-04
CA2237730A1 (en) 1997-06-19
HK1017886A1 (en) 1999-12-03
US5922867A (en) 1999-07-13
IL124663A0 (en) 1998-12-06
US6069250A (en) 2000-05-30
AP879A (en) 2000-10-02
KR19990072141A (ko) 1999-09-27
PL188447B1 (pl) 2005-02-28
EP0970074A1 (en) 2000-01-12
IN187349B (Direct) 2002-03-30
HU224076B1 (hu) 2005-05-30
DE69620042D1 (de) 2002-04-25
US20030060476A1 (en) 2003-03-27
HUP9901050A3 (en) 2001-05-28
EP0970074B1 (en) 2002-03-20
AP9801252A0 (en) 1998-06-30
US20020058670A1 (en) 2002-05-16
NZ323855A (en) 1999-11-29
EA000844B1 (ru) 2000-06-26
MX9804701A (es) 1998-10-31
CN1208414A (zh) 1999-02-17
BR9612351A (pt) 1999-07-13
WO1997021706A1 (en) 1997-06-19
HUP9901050A2 (hu) 2001-04-28
JP2000501714A (ja) 2000-02-15
IL144155A0 (en) 2002-05-23
IL144155A (en) 2003-07-06
GB9525606D0 (en) 1996-02-14
OA11094A (en) 2003-03-13
ZA9610544B (en) 1997-07-29
JP3229990B2 (ja) 2001-11-19
PL327443A1 (en) 1998-12-07
NO982716L (no) 1998-06-12
TW341574B (en) 1998-10-01
AU706328B2 (en) 1999-06-17
PT970074E (pt) 2002-09-30
IL124663A (en) 2001-10-31
NO982716D0 (no) 1998-06-12
AU1089397A (en) 1997-07-03
EA199800555A1 (ru) 1999-02-25

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