NO309090B1 - Nye indolforbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem - Google Patents
Nye indolforbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem Download PDFInfo
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- NO309090B1 NO309090B1 NO962360A NO962360A NO309090B1 NO 309090 B1 NO309090 B1 NO 309090B1 NO 962360 A NO962360 A NO 962360A NO 962360 A NO962360 A NO 962360A NO 309090 B1 NO309090 B1 NO 309090B1
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- pyrrolidin
- acid
- preparation
- Prior art date
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- HHUXMVSOOZIODW-UHFFFAOYSA-N methyl 2-(5-methoxy-1-methylindol-3-yl)acetate Chemical compound C1=C(OC)C=C2C(CC(=O)OC)=CN(C)C2=C1 HHUXMVSOOZIODW-UHFFFAOYSA-N 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000000701 neuroleptic effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 150000004031 phenylhydrazines Chemical class 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 description 1
- 230000002295 serotoninergic effect Effects 0.000 description 1
- 108010085082 sigma receptors Proteins 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000015883 synaptic transmission, dopaminergic Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9506663A FR2735129B1 (fr) | 1995-06-07 | 1995-06-07 | Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO962360D0 NO962360D0 (no) | 1996-06-06 |
| NO962360L NO962360L (no) | 1996-12-09 |
| NO309090B1 true NO309090B1 (no) | 2000-12-11 |
Family
ID=9479672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO962360A NO309090B1 (no) | 1995-06-07 | 1996-06-06 | Nye indolforbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5703070A (el) |
| EP (1) | EP0747379B1 (el) |
| JP (1) | JPH08333362A (el) |
| CN (1) | CN1060772C (el) |
| AT (1) | ATE183183T1 (el) |
| AU (1) | AU702285B2 (el) |
| CA (1) | CA2178302C (el) |
| DE (1) | DE69603667T2 (el) |
| DK (1) | DK0747379T3 (el) |
| ES (1) | ES2137638T3 (el) |
| FR (1) | FR2735129B1 (el) |
| GR (1) | GR3031051T3 (el) |
| NO (1) | NO309090B1 (el) |
| NZ (1) | NZ286756A (el) |
| ZA (1) | ZA964842B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| GB9718712D0 (en) | 1997-09-03 | 1997-11-12 | Merck Sharp & Dohme | Theraputic Agents |
| GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB9805716D0 (en) * | 1998-03-17 | 1998-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| GB9815317D0 (en) * | 1998-07-15 | 1998-09-16 | Merck Sharp & Dohme | Therapeutic agents |
| GB9816263D0 (en) * | 1998-07-24 | 1998-09-23 | Merck Sharp & Dohme | Therapeutic agents |
| CN101016296A (zh) * | 2000-04-28 | 2007-08-15 | 阿卡蒂亚药品公司 | 毒蕈碱性激动剂 |
| JP4520851B2 (ja) * | 2002-07-19 | 2010-08-11 | 明治乳業株式会社 | インドール誘導体及びこれを含有する医薬 |
| WO2009076404A1 (en) * | 2007-12-10 | 2009-06-18 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| JP2011506466A (ja) | 2007-12-11 | 2011-03-03 | 株式会社サイトパスファインダー | カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2708913A1 (de) * | 1976-03-04 | 1977-09-08 | Hoechst Ag | Benzoylpiperidyalkyl-indole und verwandte verbindungen |
| JPH0615529B2 (ja) * | 1985-04-01 | 1994-03-02 | エーザイ株式会社 | 新規ピペリジン誘導体 |
| US5030639A (en) * | 1987-07-13 | 1991-07-09 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
| US4980365A (en) * | 1987-07-13 | 1990-12-25 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
| FR2644786B1 (fr) * | 1989-03-21 | 1993-12-31 | Adir Cie | Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2716680B1 (fr) * | 1994-02-25 | 1996-04-05 | Adir | Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1995
- 1995-06-07 FR FR9506663A patent/FR2735129B1/fr not_active Expired - Fee Related
-
1996
- 1996-06-04 JP JP8141436A patent/JPH08333362A/ja active Pending
- 1996-06-05 CN CN96107985A patent/CN1060772C/zh not_active Expired - Fee Related
- 1996-06-05 CA CA002178302A patent/CA2178302C/fr not_active Expired - Fee Related
- 1996-06-05 AU AU54735/96A patent/AU702285B2/en not_active Ceased
- 1996-06-06 DK DK96401208T patent/DK0747379T3/da active
- 1996-06-06 US US08/663,464 patent/US5703070A/en not_active Expired - Fee Related
- 1996-06-06 NO NO962360A patent/NO309090B1/no not_active IP Right Cessation
- 1996-06-06 EP EP96401208A patent/EP0747379B1/fr not_active Expired - Lifetime
- 1996-06-06 DE DE69603667T patent/DE69603667T2/de not_active Expired - Fee Related
- 1996-06-06 AT AT96401208T patent/ATE183183T1/de not_active IP Right Cessation
- 1996-06-06 ES ES96401208T patent/ES2137638T3/es not_active Expired - Lifetime
- 1996-06-06 NZ NZ286756A patent/NZ286756A/xx unknown
- 1996-06-07 ZA ZA964842A patent/ZA964842B/xx unknown
-
1999
- 1999-08-20 GR GR990402129T patent/GR3031051T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2178302A1 (fr) | 1996-12-08 |
| AU5473596A (en) | 1996-12-19 |
| US5703070A (en) | 1997-12-30 |
| ATE183183T1 (de) | 1999-08-15 |
| DE69603667T2 (de) | 2000-03-09 |
| EP0747379B1 (fr) | 1999-08-11 |
| AU702285B2 (en) | 1999-02-18 |
| CN1143642A (zh) | 1997-02-26 |
| EP0747379A1 (fr) | 1996-12-11 |
| CA2178302C (fr) | 2002-02-26 |
| FR2735129A1 (fr) | 1996-12-13 |
| ES2137638T3 (es) | 1999-12-16 |
| NO962360D0 (no) | 1996-06-06 |
| DE69603667D1 (de) | 1999-09-16 |
| NO962360L (no) | 1996-12-09 |
| CN1060772C (zh) | 2001-01-17 |
| DK0747379T3 (da) | 2000-01-31 |
| GR3031051T3 (en) | 1999-12-31 |
| FR2735129B1 (fr) | 1997-07-11 |
| NZ286756A (en) | 1997-08-22 |
| ZA964842B (en) | 1997-01-07 |
| JPH08333362A (ja) | 1996-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |