NO307474B1 - Rekombinant DNA-molekyl, plasmid som omfatter det, protein som er kodet av det, fremgangsmõte for fremstilling av proteinet, fusjonsprotein som omfatter proteinet, samt DNA-sekvens som koder for fusjonsproteinet - Google Patents
Rekombinant DNA-molekyl, plasmid som omfatter det, protein som er kodet av det, fremgangsmõte for fremstilling av proteinet, fusjonsprotein som omfatter proteinet, samt DNA-sekvens som koder for fusjonsproteinet Download PDFInfo
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- NO307474B1 NO307474B1 NO924192A NO924192A NO307474B1 NO 307474 B1 NO307474 B1 NO 307474B1 NO 924192 A NO924192 A NO 924192A NO 924192 A NO924192 A NO 924192A NO 307474 B1 NO307474 B1 NO 307474B1
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- SFWLDKQAUHFCBS-WWXQEMPQSA-N lancovutide Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H]2C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@@H](CCCCNC[C@H]4C(=O)N[C@@H](CC=5C=CC=CC=5)C(=O)NCC(=O)N5CCC[C@H]5C(=O)N[C@@H](CC=5C=CC=CC=5)C(=O)N[C@H]([C@@H](SC[C@H](NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSC3C)CSC2)C(=O)N4)C)C(=O)N1)C(O)=O)[C@@H](O)C(O)=O)=O)C(C)C)C1=CC=CC=C1 SFWLDKQAUHFCBS-WWXQEMPQSA-N 0.000 description 1
- 108010079437 lanthionine synthase Proteins 0.000 description 1
- 108010005817 lanthiopeptin Proteins 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 101150086745 pre gene Proteins 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 108020000318 saccharopine dehydrogenase Proteins 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000856 sucrose gradient centrifugation Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- POSZUTFLHGNLHX-KSBRXOFISA-N tris maleate Chemical compound OCC(N)(CO)CO.OCC(N)(CO)CO.OC(=O)\C=C/C(O)=O POSZUTFLHGNLHX-KSBRXOFISA-N 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Epoxy Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78423491A | 1991-10-31 | 1991-10-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO924192D0 NO924192D0 (no) | 1992-10-30 |
| NO924192L NO924192L (no) | 1993-05-03 |
| NO307474B1 true NO307474B1 (no) | 2000-04-10 |
Family
ID=25131778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO924192A NO307474B1 (no) | 1991-10-31 | 1992-10-30 | Rekombinant DNA-molekyl, plasmid som omfatter det, protein som er kodet av det, fremgangsmõte for fremstilling av proteinet, fusjonsprotein som omfatter proteinet, samt DNA-sekvens som koder for fusjonsproteinet |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0543195B1 (de) |
| JP (1) | JP4117033B2 (de) |
| KR (1) | KR100242268B1 (de) |
| AT (1) | ATE162852T1 (de) |
| AU (1) | AU661054B2 (de) |
| CA (1) | CA2081704C (de) |
| CZ (2) | CZ284861B6 (de) |
| DE (1) | DE69224269T2 (de) |
| DK (1) | DK0543195T3 (de) |
| ES (1) | ES2112289T3 (de) |
| FI (1) | FI104498B (de) |
| GR (1) | GR3026465T3 (de) |
| HU (1) | HU215548B (de) |
| IL (1) | IL103603A (de) |
| MX (1) | MX9206265A (de) |
| NO (1) | NO307474B1 (de) |
| NZ (1) | NZ244976A (de) |
| ZA (1) | ZA928397B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639949A (en) * | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US5662898A (en) * | 1990-08-20 | 1997-09-02 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US6117670A (en) * | 1994-06-08 | 2000-09-12 | Novartis Finance Corporation | Pyrrolnitrin biosynthesis genes and uses thereof |
| US6475771B1 (en) | 1997-06-10 | 2002-11-05 | University Of Florida Research Foundation | Antimicrobial polypeptides and methods of use |
| US5932469A (en) | 1997-06-10 | 1999-08-03 | University Of Florida | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US6964760B2 (en) | 1997-06-10 | 2005-11-15 | University Of Florida Research Foundation | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US6861236B2 (en) | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| DE10261782A1 (de) * | 2002-12-19 | 2004-07-01 | Dr. Petry Genmedics Gmbh | Neue Gene und Genprodukte |
| CN101115838B (zh) | 2004-12-07 | 2015-08-12 | 莫菲西斯公司 | 产生和分泌修饰的肽的方法 |
| CN115261274B (zh) * | 2022-08-05 | 2023-11-21 | 天康制药股份有限公司 | 一种表皮葡萄球菌高密度发酵培养基及其发酵方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8811761D0 (en) * | 1988-05-18 | 1988-06-22 | Thomae Gmbh Dr K | Biosynthetic process for preparation of chemical compounds |
-
1992
- 1992-10-29 FI FI924909A patent/FI104498B/fi not_active IP Right Cessation
- 1992-10-29 CA CA002081704A patent/CA2081704C/en not_active Expired - Lifetime
- 1992-10-29 KR KR1019920020041A patent/KR100242268B1/ko not_active IP Right Cessation
- 1992-10-30 HU HU9203434A patent/HU215548B/hu unknown
- 1992-10-30 ES ES92118598T patent/ES2112289T3/es not_active Expired - Lifetime
- 1992-10-30 AU AU27459/92A patent/AU661054B2/en not_active Expired
- 1992-10-30 CZ CZ963593A patent/CZ284861B6/cs not_active IP Right Cessation
- 1992-10-30 NO NO924192A patent/NO307474B1/no not_active IP Right Cessation
- 1992-10-30 CZ CS19923269A patent/CZ286727B6/cs not_active IP Right Cessation
- 1992-10-30 AT AT92118598T patent/ATE162852T1/de active
- 1992-10-30 DK DK92118598T patent/DK0543195T3/da active
- 1992-10-30 ZA ZA928397A patent/ZA928397B/xx unknown
- 1992-10-30 DE DE69224269T patent/DE69224269T2/de not_active Expired - Lifetime
- 1992-10-30 EP EP92118598A patent/EP0543195B1/de not_active Expired - Lifetime
- 1992-10-30 IL IL10360392A patent/IL103603A/en not_active IP Right Cessation
- 1992-10-30 MX MX9206265A patent/MX9206265A/es unknown
- 1992-11-02 JP JP31553392A patent/JP4117033B2/ja not_active Expired - Lifetime
- 1992-11-02 NZ NZ244976A patent/NZ244976A/en not_active IP Right Cessation
-
1998
- 1998-03-27 GR GR980400649T patent/GR3026465T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0543195B1 (de) | 1998-01-28 |
| GR3026465T3 (en) | 1998-06-30 |
| DE69224269T2 (de) | 1998-06-04 |
| AU661054B2 (en) | 1995-07-13 |
| CZ286727B6 (cs) | 2000-06-14 |
| CZ359396A3 (cs) | 1999-03-17 |
| FI924909A (fi) | 1993-05-01 |
| EP0543195A2 (de) | 1993-05-26 |
| FI924909A0 (fi) | 1992-10-29 |
| CA2081704A1 (en) | 1993-05-01 |
| AU2745992A (en) | 1993-05-27 |
| HU9203434D0 (en) | 1993-01-28 |
| IL103603A0 (en) | 1993-03-15 |
| DE69224269D1 (de) | 1998-03-05 |
| EP0543195A3 (en) | 1994-06-08 |
| KR100242268B1 (ko) | 2000-02-01 |
| HUT65492A (en) | 1994-06-28 |
| DK0543195T3 (da) | 1998-09-23 |
| KR930008147A (ko) | 1993-05-21 |
| JPH05292952A (ja) | 1993-11-09 |
| IL103603A (en) | 1999-12-31 |
| NZ244976A (en) | 1995-07-26 |
| NO924192D0 (no) | 1992-10-30 |
| CZ284861B6 (cs) | 1999-03-17 |
| HU215548B (hu) | 1999-01-28 |
| JP4117033B2 (ja) | 2008-07-09 |
| ATE162852T1 (de) | 1998-02-15 |
| MX9206265A (es) | 1994-05-31 |
| ZA928397B (en) | 1994-05-02 |
| FI104498B (fi) | 2000-02-15 |
| CA2081704C (en) | 2007-05-01 |
| CZ326992A3 (en) | 1993-09-15 |
| NO924192L (no) | 1993-05-03 |
| ES2112289T3 (es) | 1998-04-01 |
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Legal Events
| Date | Code | Title | Description |
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| MK1K | Patent expired |