NO305907B1 - Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler - Google Patents

Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler

Info

Publication number
NO305907B1
NO305907B1 NO961072A NO961072A NO305907B1 NO 305907 B1 NO305907 B1 NO 305907B1 NO 961072 A NO961072 A NO 961072A NO 961072 A NO961072 A NO 961072A NO 305907 B1 NO305907 B1 NO 305907B1
Authority
NO
Norway
Prior art keywords
compounds
drugs
diseases
manufacture
control
Prior art date
Application number
NO961072A
Other languages
English (en)
Norwegian (no)
Other versions
NO961072L (no
NO961072D0 (no
Inventor
Mathias Osswald
Werner Mederski
Dieter Dorsch
Claudia Wilm
Claus Schmitges
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO961072D0 publication Critical patent/NO961072D0/no
Publication of NO961072L publication Critical patent/NO961072L/no
Publication of NO305907B1 publication Critical patent/NO305907B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO961072A 1995-03-18 1996-03-15 Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler NO305907B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19509950A DE19509950A1 (de) 1995-03-18 1995-03-18 Endothelin-Rezeptor-Antagonisten

Publications (3)

Publication Number Publication Date
NO961072D0 NO961072D0 (no) 1996-03-15
NO961072L NO961072L (no) 1996-09-19
NO305907B1 true NO305907B1 (no) 1999-08-16

Family

ID=7757094

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961072A NO305907B1 (no) 1995-03-18 1996-03-15 Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler

Country Status (26)

Country Link
US (1) US5726194A (ko)
EP (1) EP0733626B1 (ko)
JP (1) JPH08269027A (ko)
KR (1) KR100424045B1 (ko)
CN (1) CN1061652C (ko)
AR (1) AR002284A1 (ko)
AT (1) ATE175666T1 (ko)
AU (1) AU705559B2 (ko)
BR (1) BR9601028A (ko)
CA (1) CA2171934C (ko)
CO (1) CO4700473A1 (ko)
CZ (1) CZ288001B6 (ko)
DE (2) DE19509950A1 (ko)
DK (1) DK0733626T3 (ko)
ES (1) ES2128117T3 (ko)
FI (1) FI960953A (ko)
GR (1) GR3029893T3 (ko)
HU (1) HUP9600663A3 (ko)
NO (1) NO305907B1 (ko)
PL (1) PL184332B1 (ko)
RU (1) RU2168503C2 (ko)
SK (1) SK280926B6 (ko)
TR (1) TR199600212A2 (ko)
TW (1) TW363060B (ko)
UA (1) UA48116C2 (ko)
ZA (1) ZA962144B (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
DE19543639A1 (de) * 1995-11-23 1997-05-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
SG87052A1 (en) 1996-02-20 2002-03-19 Bristol Myers Squibb Co Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
DE19606980A1 (de) * 1996-02-24 1997-08-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19607096A1 (de) * 1996-02-24 1997-08-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
DE19653037A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
DE19710831A1 (de) * 1997-03-15 1998-09-17 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19712141A1 (de) * 1997-03-22 1998-09-24 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
JP3455233B2 (ja) 1997-04-28 2003-10-14 テキサス・バイオテクノロジー・コーポレイシヨン エンドテリン介在障害治療用のスルホンアミド類
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
DE19731571A1 (de) * 1997-07-23 1999-01-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
JP2002540088A (ja) 1999-03-19 2002-11-26 ブリストル−マイヤーズ スクイブ カンパニー ビフェニルイソキサゾール・スルホンアミド化合物の製造法
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
RU2008136317A (ru) * 2006-03-13 2010-04-20 Инсайсив Фармасьютикалз, Инк. (US) Способы и композиции для лечения диагностикой сердечной недостаточности
AU2007225207A1 (en) * 2006-03-13 2007-09-20 Encysive Pharmaceuticals, Inc. Formulations of sitaxsentan sodium
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
CN102924412A (zh) * 2008-01-25 2013-02-13 先正达参股股份有限公司 用作杀虫剂的2-氰基苯基磺酰胺衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5464853A (en) * 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5378715A (en) * 1992-02-24 1995-01-03 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
HUP9600663A2 (en) 1997-01-28
CN1061652C (zh) 2001-02-07
CO4700473A1 (es) 1998-12-29
DE59601122D1 (de) 1999-02-25
ES2128117T3 (es) 1999-05-01
HU9600663D0 (en) 1996-05-28
FI960953A (fi) 1996-09-19
TW363060B (en) 1999-07-01
TR199600212A2 (tr) 1997-01-21
NO961072L (no) 1996-09-19
US5726194A (en) 1998-03-10
CZ80096A3 (en) 1996-10-16
CN1141919A (zh) 1997-02-05
CA2171934A1 (en) 1996-09-19
KR100424045B1 (ko) 2004-06-26
GR3029893T3 (en) 1999-07-30
ATE175666T1 (de) 1999-01-15
CZ288001B6 (cs) 2001-03-14
BR9601028A (pt) 1997-12-30
AR002284A1 (es) 1998-03-11
EP0733626B1 (de) 1999-01-13
SK280926B6 (sk) 2000-09-12
SK36396A3 (en) 1997-02-05
AU4803996A (en) 1996-09-26
DE19509950A1 (de) 1996-09-19
EP0733626A1 (de) 1996-09-25
DK0733626T3 (da) 1999-08-09
JPH08269027A (ja) 1996-10-15
PL184332B1 (pl) 2002-10-31
PL313280A1 (en) 1996-09-30
FI960953A0 (fi) 1996-02-29
KR960034189A (ko) 1996-10-22
CA2171934C (en) 2007-04-24
AU705559B2 (en) 1999-05-27
NO961072D0 (no) 1996-03-15
UA48116C2 (uk) 2002-08-15
ZA962144B (en) 1996-09-26
HUP9600663A3 (en) 1998-07-28
RU2168503C2 (ru) 2001-06-10

Similar Documents

Publication Publication Date Title
NO305907B1 (no) Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler
NO305906B1 (no) Adhesjonsreseptorantagonister, farmasöytiske preparater som inneholder slike forbindelser, samt anvendelse av forbindelsene til fremstilling av legemidler
NO308296B1 (no) Indolyl neuropeptid Y reseptorantagonister, farmasøytisk formulering omfattende samme og anvendelse av samme for fremstilling av legemiddel
NO973923L (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
IT1289160B1 (it) Compressa farmaceutica completamente rivestita per il rilascio controllato di principi attivi che presentano problemi di
NO976084L (no) Ny, stabil legemiddeltilberedning for dannelse av drivgassfrie aerosoler
NO20042694L (no) 17 alfa-alkyl-17 beta-oksy-ostratriener og mellomprodukter for fremstilling av disse, anvendelse av 17 alfa-alkyl-17 beta-oksy-ostratrienene til fremstilling av legemidler samt farmasoytiske preparater
DK0966454T3 (da) Disubstituerede bicykliske heterocykler, deres fremstilling og deres anvendelse som lægemidler
FI913248A0 (fi) Kontrollerat frigoerande fast farmaceutisk doseringsform.
DE69427472D1 (de) Arzneimittel mit kontrollierter Wirkstoffabgabe
NO965377D0 (no) Indolinonforbindelser samt farmasöytiske preparater inneholdende forbindelsene
HUP9603298A3 (en) Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation, and their use for the preparation of pharmaceutical compositions
NO973608D0 (no) Nye farnesyl-transferaseinhibitorer, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
NO307459B1 (no) Piperazinderivater, samt farmasøytiske preparater inneholdende slike
NO305903B1 (no) Benzonitriler og benzofluorider, legemidler bestående av forbindelsene, farmasöytiske preparater inneholdende forbindelsene, samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
NO981008D0 (no) Farmasöytisk formulering
NO307510B1 (no) Bicykliske aromatiske forbindelser, deres anvendelse og farmasøytiske og kosmetiske preparater derav
NO306113B1 (no) Adhesjonsreseptorantagonister, farmasöytiske preparater som inneholder slike forbindelser, samt anvendelse av forbindelsene til fremstilling av legemidler
HUP9903353A3 (en) 7alpha-(methyl-amino-pentyl)-estratrienes, pharmaceutical preparations which contain said 7alpha-(5-methylaminopentyl) -estratrienes and use thereof for production of drugs
NO306060B1 (no) Substituerte kanelsyreguanidider, deres anvendelse samt medikamenter inneholdende guanididene
NO974563D0 (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
NO305836B1 (no) Oksazolidin-2-on-forbindelser, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
NO305793B1 (no) 4-aminobenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
BR9607433A (pt) Composição farmacêutica para administração parental
NO306993B1 (no) Piperidinylmetyloksyzolidin-2-on-derivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees