NO305367B1 - Nye colon- eller ileum-spesifikke steroidderivater, farmas°ytisk preparat inneholdende slike, og anvendelse av derivatene - Google Patents

Nye colon- eller ileum-spesifikke steroidderivater, farmas°ytisk preparat inneholdende slike, og anvendelse av derivatene

Info

Publication number
NO305367B1
NO305367B1 NO952683A NO952683A NO305367B1 NO 305367 B1 NO305367 B1 NO 305367B1 NO 952683 A NO952683 A NO 952683A NO 952683 A NO952683 A NO 952683A NO 305367 B1 NO305367 B1 NO 305367B1
Authority
NO
Norway
Prior art keywords
derivatives
ileum
pharmaceutical preparations
preparations containing
specific steroid
Prior art date
Application number
NO952683A
Other languages
English (en)
Norwegian (no)
Other versions
NO952683L (no
NO952683D0 (no
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hoegberg
Stinabritt Nilsson
Bror Arne Thalun
Jan Erik Ulmius
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO952683L publication Critical patent/NO952683L/no
Publication of NO952683D0 publication Critical patent/NO952683D0/no
Publication of NO305367B1 publication Critical patent/NO305367B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
NO952683A 1993-01-08 1995-07-06 Nye colon- eller ileum-spesifikke steroidderivater, farmas°ytisk preparat inneholdende slike, og anvendelse av derivatene NO305367B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (en) 1993-01-08 1993-12-17 Novel colon- or ileum-specific steroid derivatives

Publications (3)

Publication Number Publication Date
NO952683L NO952683L (no) 1995-07-06
NO952683D0 NO952683D0 (no) 1995-07-06
NO305367B1 true NO305367B1 (no) 1999-05-18

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952683A NO305367B1 (no) 1993-01-08 1995-07-06 Nye colon- eller ileum-spesifikke steroidderivater, farmas°ytisk preparat inneholdende slike, og anvendelse av derivatene

Country Status (22)

Country Link
US (2) US5908833A (forum.php)
EP (1) EP0678097B1 (forum.php)
JP (1) JP3366640B2 (forum.php)
KR (1) KR960700266A (forum.php)
AT (1) ATE183192T1 (forum.php)
BR (1) BR9307746A (forum.php)
CA (1) CA2152374A1 (forum.php)
CZ (1) CZ171095A3 (forum.php)
DK (1) DK0678097T3 (forum.php)
ES (1) ES2137353T3 (forum.php)
FI (1) FI953358A7 (forum.php)
GR (1) GR3031789T3 (forum.php)
HU (1) HU221584B (forum.php)
IS (1) IS4111A (forum.php)
LV (1) LV10961B (forum.php)
NO (1) NO305367B1 (forum.php)
NZ (1) NZ259596A (forum.php)
PL (1) PL178307B1 (forum.php)
RU (1) RU95115547A (forum.php)
SK (1) SK87295A3 (forum.php)
TW (1) TW261615B (forum.php)
WO (1) WO1994015947A1 (forum.php)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0678097T3 (da) * 1993-01-08 2000-02-07 Astra Ab Hidtil ukendte colon- eller ileumspecifikke steroidderivater
EP0721956B1 (en) * 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
IL146284A0 (en) 1999-05-04 2002-07-25 Strakan Ltd Androgen glycosides and pharmaceutical compositions containing the same
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
HK1046244B (zh) 1999-06-14 2005-06-03 科斯默技术有限公司 控制释放与掩蔽味道的口服药物组合物
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
ATE411053T1 (de) * 2004-08-09 2008-10-15 Deutsches Krebsforsch Albuminkonjugate, die eine glucuron-verknüpfung enthalten
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP7330101B2 (ja) 2016-11-08 2023-08-21 レゲネロン ファーマシューティカルス，インコーポレーテッド ステロイド及びそのタンパク質コンジュゲート
WO2018177381A1 (zh) * 2017-03-30 2018-10-04 合肥合源药业有限公司 乳果糖糖苷化合物、其制备方法及其用途
KR20200007905A (ko) 2017-05-18 2020-01-22 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
IL274427B2 (en) 2017-11-07 2024-11-01 Regeneron Pharma Hydrophilic linkers for antibody drug conjugates
SG11202006510XA (en) 2018-01-08 2020-08-28 Regeneron Pharma Steroids and antibody-conjugates thereof
US11377502B2 (en) 2018-05-09 2022-07-05 Regeneron Pharmaceuticals, Inc. Anti-MSR1 antibodies and methods of use thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (forum.php) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (forum.php) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
DE2967070D1 (en) * 1978-01-25 1984-08-02 Schering Ag 11,17-substituted pregnanes, their preparation and application for the preparation of pharmaceutical compositions
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
AU594468B2 (en) * 1986-05-12 1990-03-08 Mect Corporation Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
DK0678097T3 (da) * 1993-01-08 2000-02-07 Astra Ab Hidtil ukendte colon- eller ileumspecifikke steroidderivater

Also Published As

Publication number Publication date
ES2137353T3 (es) 1999-12-16
EP0678097B1 (en) 1999-08-11
JP3366640B2 (ja) 2003-01-14
RU95115547A (ru) 1997-06-10
JPH08505616A (ja) 1996-06-18
FI953358A0 (fi) 1995-07-07
CA2152374A1 (en) 1994-07-21
SK87295A3 (en) 1996-04-03
FI953358L (fi) 1995-07-07
BR9307746A (pt) 1995-11-14
CZ171095A3 (en) 1996-01-17
DK0678097T3 (da) 2000-02-07
AU5844794A (en) 1994-08-15
PL178307B1 (pl) 2000-04-28
US6140308A (en) 2000-10-31
HUT73227A (en) 1996-07-29
NZ259596A (en) 1997-04-24
US5908833A (en) 1999-06-01
HU9502087D0 (en) 1995-09-28
LV10961B (en) 1996-08-20
PL309777A1 (en) 1995-11-13
AU678803B2 (en) 1997-06-12
NO952683L (no) 1995-07-06
HU221584B (hu) 2002-11-28
WO1994015947A1 (en) 1994-07-21
ATE183192T1 (de) 1999-08-15
FI953358A7 (fi) 1995-07-07
IS4111A (is) 1994-07-09
EP0678097A1 (en) 1995-10-25
TW261615B (forum.php) 1995-11-01
LV10961A (lv) 1995-12-20
GR3031789T3 (en) 2000-02-29
KR960700266A (ko) 1996-01-19
NO952683D0 (no) 1995-07-06

Similar Documents

Publication Publication Date Title
NO305367B1 (no) Nye colon- eller ileum-spesifikke steroidderivater, farmas°ytisk preparat inneholdende slike, og anvendelse av derivatene
FI951454A0 (fi) 1-(2-oksoasetyyli)piperidiini-2-karboksyylihappojohdannaiset monille lääkkeille resistenttien syöpäsolujen herkistäjinä
AU649421B2 (en) Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs
NO20015226L (no) Tri-aryl syrederivater som PPAR reseptor ligander, farmasoytisk sammensetning omfattende samme og anvendelse av samme for fremstilling av medikament.
BR9810592A (pt) Composto, processos para preparar um composto, para tratar ou prevenir doenças do sistema endócrino e para a fabricação de um medicamento, composição farmacêutica, e, uso de um composto
SE9904505D0 (sv) Novel compounds
CA2186380A1 (en) Novel carbamates and ureas as modifiers of multi-drug resistance
DE3480705D1 (de) Gewisse 3-(5-aminopentyl)-amino-1-benzazepin-2-on-1-alkansaeuren, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie ihre therapeutische verwendung.
SE9801992D0 (sv) New 3-aryl-2-hydroxypropionic acid derivative I
BR9807824A (pt) Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
NO883229L (no) Nye benzimidazolderivater, fremgangsmaate for deres fremstilling og farmasoeytisk preparat inneholdende slike derivater.
BR0012610A (pt) Novo derivado de difenilpiperidina
ATE27451T1 (de) Acyl-chinolinonderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung.
SE8405588D0 (sv) New compounds
DE3770726D1 (de) Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.
ZA968762B (en) Derivatives of acid pyrazoles, their preparation process, their use as medicaments, their new use and the pharmaceutical compositions containing them.
DE3682370D1 (de) 3-aminocarbonyl-1,4-dihydropyridin-5-carboxylsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung und diese enthaltende pharmazeutische zusammensetzungen.
NO991481D0 (no) Nye heteroaryloksyetylaminer, fremgangsmÕte for fremstilling av, anvendelse som medisin og farmas°ytiske blandinger inneholdende disse
DE60237994D1 (de) 3.beta.,28-diacetoxy-18-oxo-19,20,21,29,30-pentanorlupan-22-säure solvate, verfahren zu ihrer herstellung und pharmazeutische präparate daraus
DK1023059T3 (da) Farmaceutiske præparater
AU2003298203A1 (en) Medicaments containing substituted 2,5-diaminomethyl-1h-pyrroles
ECSP951622A (es) Compuestos quimicos
ATE64384T1 (de) Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.