NO305036B1 - FremgangsmÕte for fremstilling av humant trombinkonsentrat for terapeutisk anvendelse - Google Patents
FremgangsmÕte for fremstilling av humant trombinkonsentrat for terapeutisk anvendelse Download PDFInfo
- Publication number
- NO305036B1 NO305036B1 NO922809A NO922809A NO305036B1 NO 305036 B1 NO305036 B1 NO 305036B1 NO 922809 A NO922809 A NO 922809A NO 922809 A NO922809 A NO 922809A NO 305036 B1 NO305036 B1 NO 305036B1
- Authority
- NO
- Norway
- Prior art keywords
- thrombin
- ppsb
- concentration
- concentrate
- sodium chloride
- Prior art date
Links
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- 239000012141 concentrate Substances 0.000 title claims abstract description 17
- 229960003766 thrombin (human) Drugs 0.000 title claims abstract description 12
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- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title description 5
- 229960004072 thrombin Drugs 0.000 claims abstract description 69
- 108090000190 Thrombin Proteins 0.000 claims abstract description 68
- 108010012557 prothrombin complex concentrates Proteins 0.000 claims abstract description 34
- 230000000694 effects Effects 0.000 claims abstract description 18
- 230000004913 activation Effects 0.000 claims abstract description 14
- 108010094028 Prothrombin Proteins 0.000 claims abstract description 10
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- 239000011780 sodium chloride Substances 0.000 claims description 19
- 239000001110 calcium chloride Substances 0.000 claims description 16
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 16
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- 239000000176 sodium gluconate Substances 0.000 claims description 16
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- 229940005574 sodium gluconate Drugs 0.000 claims description 16
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 15
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims description 14
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- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9109075A FR2679251B1 (fr) | 1991-07-18 | 1991-07-18 | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO922809D0 NO922809D0 (no) | 1992-07-16 |
| NO922809L NO922809L (no) | 1993-01-19 |
| NO305036B1 true NO305036B1 (no) | 1999-03-22 |
Family
ID=9415256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO922809A NO305036B1 (no) | 1991-07-18 | 1992-07-16 | FremgangsmÕte for fremstilling av humant trombinkonsentrat for terapeutisk anvendelse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5304372A (da) |
| EP (1) | EP0528701B1 (da) |
| JP (1) | JP4101309B2 (da) |
| AT (1) | ATE159288T1 (da) |
| CA (1) | CA2073734C (da) |
| DE (1) | DE69222716T2 (da) |
| DK (1) | DK0528701T3 (da) |
| ES (1) | ES2108738T3 (da) |
| FR (1) | FR2679251B1 (da) |
| GR (1) | GR3025889T3 (da) |
| NO (1) | NO305036B1 (da) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595735A (en) * | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
| AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
| US5792835A (en) * | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
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| CA940070A (en) * | 1968-12-23 | 1974-01-15 | Jim S. Berry | Stabilized aqueous enzyme composition |
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-
1991
- 1991-07-18 FR FR9109075A patent/FR2679251B1/fr not_active Expired - Fee Related
-
1992
- 1992-07-02 DE DE69222716T patent/DE69222716T2/de not_active Expired - Lifetime
- 1992-07-02 AT AT92401889T patent/ATE159288T1/de active
- 1992-07-02 DK DK92401889.8T patent/DK0528701T3/da active
- 1992-07-02 ES ES92401889T patent/ES2108738T3/es not_active Expired - Lifetime
- 1992-07-02 EP EP92401889A patent/EP0528701B1/fr not_active Expired - Lifetime
- 1992-07-13 CA CA002073734A patent/CA2073734C/fr not_active Expired - Lifetime
- 1992-07-16 JP JP21074592A patent/JP4101309B2/ja not_active Expired - Fee Related
- 1992-07-16 NO NO922809A patent/NO305036B1/no not_active IP Right Cessation
- 1992-07-17 US US07/913,933 patent/US5304372A/en not_active Expired - Lifetime
-
1998
- 1998-01-14 GR GR980400062T patent/GR3025889T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2073734C (fr) | 2002-11-26 |
| EP0528701B1 (fr) | 1997-10-15 |
| DE69222716D1 (de) | 1997-11-20 |
| NO922809D0 (no) | 1992-07-16 |
| ES2108738T3 (es) | 1998-01-01 |
| NO922809L (no) | 1993-01-19 |
| GR3025889T3 (en) | 1998-04-30 |
| EP0528701A1 (fr) | 1993-02-24 |
| DE69222716T2 (de) | 1998-03-19 |
| CA2073734A1 (fr) | 1993-01-19 |
| US5304372A (en) | 1994-04-19 |
| JPH05186369A (ja) | 1993-07-27 |
| ATE159288T1 (de) | 1997-11-15 |
| FR2679251B1 (fr) | 1993-11-12 |
| DK0528701T3 (da) | 1998-05-18 |
| FR2679251A1 (fr) | 1993-01-22 |
| JP4101309B2 (ja) | 2008-06-18 |
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