ATE346145T1 - Verfahren zur stabilisierung von thrombin - Google Patents

Verfahren zur stabilisierung von thrombin

Info

Publication number
ATE346145T1
ATE346145T1 AT00961196T AT00961196T ATE346145T1 AT E346145 T1 ATE346145 T1 AT E346145T1 AT 00961196 T AT00961196 T AT 00961196T AT 00961196 T AT00961196 T AT 00961196T AT E346145 T1 ATE346145 T1 AT E346145T1
Authority
AT
Austria
Prior art keywords
thrombin
containing composition
stabilized
stabilization
effective amount
Prior art date
Application number
AT00961196T
Other languages
English (en)
Inventor
Masahiro Okuda
Norihiro Kikukawa
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Application granted granted Critical
Publication of ATE346145T1 publication Critical patent/ATE346145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
AT00961196T 1999-09-27 2000-09-22 Verfahren zur stabilisierung von thrombin ATE346145T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27209299 1999-09-27
JP2000212924 2000-07-13

Publications (1)

Publication Number Publication Date
ATE346145T1 true ATE346145T1 (de) 2006-12-15

Family

ID=26550026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00961196T ATE346145T1 (de) 1999-09-27 2000-09-22 Verfahren zur stabilisierung von thrombin

Country Status (7)

Country Link
US (1) US20060246052A1 (de)
EP (1) EP1221479B1 (de)
JP (1) JP4399615B2 (de)
AT (1) ATE346145T1 (de)
AU (1) AU7320300A (de)
DE (1) DE60032001T2 (de)
WO (1) WO2001023536A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2502481T3 (es) * 2001-01-31 2014-10-03 Asahi Kasei Pharma Corporation Composición para el análisis de proteínas glicosiladas
JP4767253B2 (ja) 2004-06-22 2011-09-07 ザイモジェネティクス， インコーポレイテッド トロンビン組成物
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
TW200718785A (en) 2005-11-10 2007-05-16 Toyo Boseki A process for improving the thermal stability of a composition containing a soluble coenzyme conjugated glucose dehydrogenase (GDH)
US8580532B2 (en) 2006-12-21 2013-11-12 Sekisui Medical Co., Ltd. Method for stabilizing α-thrombin in thrombin-containing solution
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
JP6174367B2 (ja) * 2013-04-26 2017-08-02 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法
CN104569446A (zh) * 2015-02-04 2015-04-29 上海长岛生物技术有限公司 一种液体型凝血酶时间检测试剂及其制备方法
CN104630325B (zh) * 2015-02-04 2018-03-02 上海长岛生物技术有限公司 一种液体型纤维蛋白原检测试剂及其制备方法
EA026104B1 (ru) * 2015-04-02 2017-03-31 Общество С Ограниченной Ответственностью "Тектум" Кровоостанавливающее и ранозаживляющее средство
CN105548564B (zh) * 2015-12-28 2017-03-22 青岛古高生物科技有限公司 原花青素的应用及含原花青素的纤维蛋白原测定试剂
CN112578130A (zh) * 2019-09-30 2021-03-30 积水医疗科技(苏州)有限公司 凝血酶溶液、试剂盒、凝血酶的稳定化方法、检测试剂以及凝血酶时间的测定方法
CN112941143A (zh) * 2021-01-28 2021-06-11 南京可诺医疗技术有限公司 一种简单便捷的检测凝血和血小板功能的试剂及其应用
CN116930518A (zh) * 2023-07-20 2023-10-24 山东博群生物技术有限公司 一种凝血酶时间测定试剂盒

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
ES2131504T3 (es) * 1990-02-20 1999-08-01 Baxter Int Trombina humana purificada viricamente segura.
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
DE59005286D1 (de) * 1990-10-04 1994-05-11 Kallies Import Export Vertrieb Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens.
JPH0513899A (ja) * 1991-07-02 1993-01-22 Mitsubishi Electric Corp プリント基板
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT399055B (de) * 1992-05-15 1995-03-27 Immuno Ag Verfahren zur bestimmung von fibrinogen
JP2994557B2 (ja) * 1994-09-02 1999-12-27 株式会社アズウェル フィブリノゲン測定方法およびその測定試薬
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
GB9503750D0 (en) * 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
US6582941B1 (en) * 1995-04-17 2003-06-24 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
ATE247494T1 (de) * 1996-04-04 2003-09-15 Baxter Ag Blutstillender schwamm auf kollagenbasis

Also Published As

Publication number Publication date
EP1221479A4 (de) 2004-06-16
DE60032001T2 (de) 2007-05-31
AU7320300A (en) 2001-04-30
DE60032001D1 (de) 2007-01-04
US20060246052A1 (en) 2006-11-02
JP4399615B2 (ja) 2010-01-20
EP1221479B1 (de) 2006-11-22
EP1221479A1 (de) 2002-07-10
WO2001023536A1 (en) 2001-04-05

Similar Documents

Publication Publication Date Title
DE60032001D1 (de) Verfahren zur stabilisierung von thrombin
ATE273364T1 (de) Zusammensetzungen zur stabilisierung von sauerstoffempfindlichen verbindungen
BR0210282A (pt) Veìculos de distribuição de fosfato de cálcio para proteìnas osteoindutivas
ATE246937T1 (de) Verwendung von threalose zur stabilisierung von einem flüssigen impfstoff
DK1054893T3 (da) Syntetiske polymerer og fremgangsmåder, kit eller sammensætninger til modulering af deres oplöselighed
BR0211200A (pt) Peptìdeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células
DE60229050D1 (de) Verfahren zur herstellung von ascorbinsäurezwischenprodukten in wirtszellen
DE69415524D1 (de) Synergistisch stabilisierte fluessige enzymatische zusammensetzungen
EA200600440A1 (ru) 4-((феноксиалкил)тио)еноксиуксусные кислоты и их аналоги
DE69821376D1 (de) Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
DE68910813D1 (de) Verfahren zur Stabilisierung von elektroaktiven Polymerelektroden.
ATE547122T1 (de) Zusammensetzung zur stabilisierung von hyaluronsäure
DE59712562D1 (de) Methode zur Stabilisierung von Plättchen
KR900011887A (ko) 효소 및 효소 안정화 시스템을 함유하는 액체 세제 조성물
ATE232191T1 (de) Verfahren und zusammensetzung zur inhibierung der polymerisierung von ethylenisch ungesättigten kohlenwasserstoffen
DK1474487T3 (da) Stabiliserede vandige polyurethan-polyurinstofdispersioner
WO1997008934A3 (en) Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
DE60026292D1 (de) Eine stabilisierte isothiazolon-zusammensetzung und ein verfahren zur stabilisierung von isothiazolon
WO2003044166A3 (en) METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER
BR9712851A (pt) Composições farmacêuticas compreendendo derivados de salquilisotiourÈnio
DE69617685D1 (de) Zusammensetzung und verfahren zur stabilisierung von radiomarkierten organischen verbindungen
DE59901162D1 (de) Verfahren zur Stabilisierung von Cyanhydrinen
ATE260328T1 (de) Mittel und verfahren zum abdichten oder verfestigen von fels, lockergestein oder böden, insbesondere bohrlöchern
ATE204899T1 (de) Verfahren zur herstellung von schwefelarmen aliphatischen verbindungen
ES2068796T3 (es) Producto para el moldeado permanente del cabello de dos componentes.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties