WO2003044166A3 - METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER - Google Patents

METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER Download PDF

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Publication number
WO2003044166A3
WO2003044166A3 PCT/US2002/036665 US0236665W WO03044166A3 WO 2003044166 A3 WO2003044166 A3 WO 2003044166A3 US 0236665 W US0236665 W US 0236665W WO 03044166 A3 WO03044166 A3 WO 03044166A3
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WO
WIPO (PCT)
Prior art keywords
methods
compositions
mrna
gene expression
level
Prior art date
Application number
PCT/US2002/036665
Other languages
French (fr)
Other versions
WO2003044166A2 (en
Inventor
Ching-Yi Chen
Michael Karin
Original Assignee
Univ California
Ching-Yi Chen
Michael Karin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Ching-Yi Chen, Michael Karin filed Critical Univ California
Priority to AU2002359403A priority Critical patent/AU2002359403A1/en
Publication of WO2003044166A2 publication Critical patent/WO2003044166A2/en
Publication of WO2003044166A3 publication Critical patent/WO2003044166A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides means to modulate gene expression by destabilizing or stabilizing mRNA species. The invention provides compositions and methods for altering the level of RNA, and for screening test agents that alter RNA levels. The inventions's compositions and methods are useful in, for example, increasing the level of an mRNA and conversely in decreasing the level of mRNA by impacting the level of degradation of the mRNA.
PCT/US2002/036665 2001-11-15 2002-11-14 METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER WO2003044166A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002359403A AU2002359403A1 (en) 2001-11-15 2002-11-14 METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33471201P 2001-11-15 2001-11-15
US60/334,712 2001-11-15

Publications (2)

Publication Number Publication Date
WO2003044166A2 WO2003044166A2 (en) 2003-05-30
WO2003044166A3 true WO2003044166A3 (en) 2003-12-31

Family

ID=23308474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036665 WO2003044166A2 (en) 2001-11-15 2002-11-14 METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER

Country Status (2)

Country Link
AU (1) AU2002359403A1 (en)
WO (1) WO2003044166A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9227956B2 (en) 2013-04-17 2016-01-05 Pfizer Inc. Substituted amide compounds
CN108715830A (en) * 2018-05-04 2018-10-30 中南大学湘雅医院 Urinate extracting method and its application of derived stem cell excretion body

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
JP2013526852A (en) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Circulating biomarkers for disease
US20160296560A1 (en) * 2013-10-02 2016-10-13 Xosoma Pty Ltd A method of producing exosomes
JP2018520125A (en) 2015-06-10 2018-07-26 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Use of exosomes for treatment of disease

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALLMANG ET AL.: "The yeast exosome and human PM-Scl are related complexes of 3'->5' exonucleases", GENES DEV., vol. 13, 1999, pages 2148 - 2158, XP002187891 *
GELPI ET AL.: "Identification of protein components reactive with anti-PM/Scl autoantibodies", CLIN. EXP. IMMUNOL., vol. 81, 1990, pages 59 - 64, XP002970556 *
LAROIA ET AL.: "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway", SCIENCE, vol. 284, 16 April 1999 (1999-04-16), pages 499 - 502, XP002970559 *
PORT ET AL.: "beta Adrenergic agonists that down-regulate receptor mRNA up-regulate a Mr 35,000 protein(s) that selectively binds to beta-adrenergic receptor mRNAs", J. BIOL. CHEM., vol. 267, no. 33, 25 November 1992 (1992-11-25), pages 24103 - 24108, XP002970557 *
WANG ET AL.: "Characterization of the proteins binding to the 3' regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoiesis cells", LEUKEMIA, vol. 12, 1998, pages 520 - 531, XP002970558 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9227956B2 (en) 2013-04-17 2016-01-05 Pfizer Inc. Substituted amide compounds
CN108715830A (en) * 2018-05-04 2018-10-30 中南大学湘雅医院 Urinate extracting method and its application of derived stem cell excretion body
CN108715830B (en) * 2018-05-04 2019-08-06 中南大学湘雅医院 Urinate the extracting method and its application of derived stem cell excretion body

Also Published As

Publication number Publication date
AU2002359403A1 (en) 2003-06-10
AU2002359403A8 (en) 2003-06-10
WO2003044166A2 (en) 2003-05-30

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