FR2946348B1 - Procede de preparation d'une composition de complexe prothrombique a haut degre de purete - Google Patents
Procede de preparation d'une composition de complexe prothrombique a haut degre de pureteInfo
- Publication number
- FR2946348B1 FR2946348B1 FR0902723A FR0902723A FR2946348B1 FR 2946348 B1 FR2946348 B1 FR 2946348B1 FR 0902723 A FR0902723 A FR 0902723A FR 0902723 A FR0902723 A FR 0902723A FR 2946348 B1 FR2946348 B1 FR 2946348B1
- Authority
- FR
- France
- Prior art keywords
- purity
- depth
- preparing
- complex composition
- prothrombic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0902723A FR2946348B1 (fr) | 2009-06-05 | 2009-06-05 | Procede de preparation d'une composition de complexe prothrombique a haut degre de purete |
KR1020117031284A KR20120047216A (ko) | 2009-06-05 | 2010-06-04 | 프로트롬빈 복합 조성물 |
BRPI1009641-8A BRPI1009641A2 (pt) | 2009-06-05 | 2010-06-04 | Composição de complexo protrombótico |
CA2764584A CA2764584A1 (fr) | 2009-06-05 | 2010-06-04 | Composition de complexe prothrombique |
EP10728330A EP2438165A1 (fr) | 2009-06-05 | 2010-06-04 | Composition de complexe prothrombique |
US13/376,316 US20120087907A1 (en) | 2009-06-05 | 2010-06-04 | Prothrombic complex composition |
CN2010800250346A CN102459583A (zh) | 2009-06-05 | 2010-06-04 | 凝血酶原复合体组合物 |
AU2010255377A AU2010255377A1 (en) | 2009-06-05 | 2010-06-04 | Prothrombic complex composition |
PCT/IB2010/052497 WO2010140140A1 (fr) | 2009-06-05 | 2010-06-04 | Composition de complexe prothrombique |
JP2012513730A JP2012528850A (ja) | 2009-06-05 | 2010-06-04 | プロトロンビン複合体組成物 |
IL216395A IL216395A0 (en) | 2009-06-05 | 2011-11-16 | Prothrombic complex composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0902723A FR2946348B1 (fr) | 2009-06-05 | 2009-06-05 | Procede de preparation d'une composition de complexe prothrombique a haut degre de purete |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2946348A1 FR2946348A1 (fr) | 2010-12-10 |
FR2946348B1 true FR2946348B1 (fr) | 2011-08-05 |
Family
ID=41531870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0902723A Expired - Fee Related FR2946348B1 (fr) | 2009-06-05 | 2009-06-05 | Procede de preparation d'une composition de complexe prothrombique a haut degre de purete |
Country Status (11)
Country | Link |
---|---|
US (1) | US20120087907A1 (fr) |
EP (1) | EP2438165A1 (fr) |
JP (1) | JP2012528850A (fr) |
KR (1) | KR20120047216A (fr) |
CN (1) | CN102459583A (fr) |
AU (1) | AU2010255377A1 (fr) |
BR (1) | BRPI1009641A2 (fr) |
CA (1) | CA2764584A1 (fr) |
FR (1) | FR2946348B1 (fr) |
IL (1) | IL216395A0 (fr) |
WO (1) | WO2010140140A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI641382B (zh) * | 2013-01-31 | 2018-11-21 | 韓美藥品股份有限公司 | 於包含因子vii之組成物中使病毒失活之方法 |
CN103351432A (zh) * | 2013-07-09 | 2013-10-16 | 武汉中原瑞德生物制品有限责任公司 | 从血浆组分沉淀中提取人凝血因子ⅷ和人纤维蛋白原的工艺 |
CN105440127B (zh) * | 2015-12-30 | 2018-10-16 | 上海莱士血液制品股份有限公司 | 一种以人血浆Cohn组分III为原料的FEIBA的制备方法 |
US20180369346A1 (en) * | 2016-01-07 | 2018-12-27 | Eio Biomedical Ltd. | Methods, compositions and kits for reducing tissue adhesions |
CN106139935A (zh) * | 2016-06-23 | 2016-11-23 | 广州新克力生物科技有限公司 | 一种白细胞和血小板的过滤膜及其制备方法 |
BR112019012772A2 (pt) * | 2017-02-09 | 2019-12-10 | Csl Behring Gmbh | produto de reposição de fatores de coagulação sanguínea para uso no tratamento ou profilaxia de hemorragias |
CN109943554B (zh) * | 2017-12-21 | 2021-04-16 | 舒泰神(北京)生物制药股份有限公司 | 一种从蛇毒中提取凝血因子x激活剂的方法 |
CN109593747B (zh) * | 2018-12-25 | 2021-08-10 | 山东泰邦生物制品有限公司 | 一种人凝血酶原复合物中间产品液态保存的方法 |
CN110835626B (zh) * | 2019-12-04 | 2021-12-21 | 长春雷允上药业有限公司 | 一种凝血酶的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2902158A1 (de) | 1979-01-20 | 1980-07-31 | Biotest Serum Institut Gmbh | Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen |
DE3101752A1 (de) | 1981-01-21 | 1982-08-26 | Behringwerke Ag, 3550 Marburg | "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen" |
FR2632524B1 (fr) * | 1988-06-09 | 1992-03-13 | Fondation Nale Transfusion San | Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament |
FR2679251B1 (fr) | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
US5714583A (en) | 1995-06-07 | 1998-02-03 | Genetics Institute, Inc. | Factor IX purification methods |
CZ81997A3 (en) * | 1996-03-20 | 1997-10-15 | Immuno Ag | Pharmaceutical preparation for treating disorders connected with blood clotting, process of its preparation and use |
CN101160133B (zh) * | 2004-11-05 | 2013-01-09 | 普罗瑟拉生物公司 | 治疗用途的来自人血浆的内-α抑制剂蛋白质的制备和组合物 |
KR20130128013A (ko) * | 2004-12-23 | 2013-11-25 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 관심있는 비타민 k-의존성 단백질을 포함한 조성물 중의 단백질 오염물질의 양의 감소 |
JP2006197464A (ja) | 2005-01-17 | 2006-07-27 | Sharp Corp | 電話システム |
-
2009
- 2009-06-05 FR FR0902723A patent/FR2946348B1/fr not_active Expired - Fee Related
-
2010
- 2010-06-04 JP JP2012513730A patent/JP2012528850A/ja active Pending
- 2010-06-04 AU AU2010255377A patent/AU2010255377A1/en not_active Abandoned
- 2010-06-04 BR BRPI1009641-8A patent/BRPI1009641A2/pt not_active Application Discontinuation
- 2010-06-04 US US13/376,316 patent/US20120087907A1/en not_active Abandoned
- 2010-06-04 KR KR1020117031284A patent/KR20120047216A/ko not_active Application Discontinuation
- 2010-06-04 WO PCT/IB2010/052497 patent/WO2010140140A1/fr active Application Filing
- 2010-06-04 CN CN2010800250346A patent/CN102459583A/zh active Pending
- 2010-06-04 EP EP10728330A patent/EP2438165A1/fr not_active Withdrawn
- 2010-06-04 CA CA2764584A patent/CA2764584A1/fr not_active Abandoned
-
2011
- 2011-11-16 IL IL216395A patent/IL216395A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20120087907A1 (en) | 2012-04-12 |
JP2012528850A (ja) | 2012-11-15 |
CN102459583A (zh) | 2012-05-16 |
FR2946348A1 (fr) | 2010-12-10 |
BRPI1009641A2 (pt) | 2015-08-18 |
EP2438165A1 (fr) | 2012-04-11 |
AU2010255377A1 (en) | 2011-12-15 |
WO2010140140A1 (fr) | 2010-12-09 |
KR20120047216A (ko) | 2012-05-11 |
IL216395A0 (en) | 2012-01-31 |
CA2764584A1 (fr) | 2010-12-09 |
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