NO304794B1 - Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder - Google Patents

Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder

Info

Publication number
NO304794B1
NO304794B1 NO941678A NO941680A NO304794B1 NO 304794 B1 NO304794 B1 NO 304794B1 NO 941678 A NO941678 A NO 941678A NO 941680 A NO941680 A NO 941680A NO 304794 B1 NO304794 B1 NO 304794B1
Authority
NO
Norway
Prior art keywords
preparation
acid derivatives
bile acid
hypolipidemics
medicinal preparations
Prior art date
Application number
NO941678A
Other languages
English (en)
Norwegian (no)
Other versions
NO941680D0 (no
NO941680L (no
Inventor
Heiner Glombik
Alfons Enhsen
Werner Kramer
Gunther Wess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO941680D0 publication Critical patent/NO941680D0/no
Publication of NO941680L publication Critical patent/NO941680L/no
Publication of NO304794B1 publication Critical patent/NO304794B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO941678A 1993-05-08 1994-05-06 Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder NO304794B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4315439 1993-05-08

Publications (3)

Publication Number Publication Date
NO941680D0 NO941680D0 (no) 1994-05-06
NO941680L NO941680L (no) 1994-11-09
NO304794B1 true NO304794B1 (no) 1999-02-15

Family

ID=6487634

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941678A NO304794B1 (no) 1993-05-08 1994-05-06 Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder

Country Status (18)

Country Link
US (1) US5610151A (sl)
EP (1) EP0624594B1 (sl)
JP (1) JP3424978B2 (sl)
KR (1) KR100333151B1 (sl)
AT (1) ATE183191T1 (sl)
AU (1) AU673419B2 (sl)
CA (1) CA2123052C (sl)
CZ (1) CZ289209B6 (sl)
DE (1) DE59408602D1 (sl)
DK (1) DK0624594T3 (sl)
ES (1) ES2136677T3 (sl)
FI (1) FI942077A (sl)
GR (1) GR3031541T3 (sl)
HU (1) HUT67574A (sl)
IL (1) IL109580A (sl)
NO (1) NO304794B1 (sl)
NZ (1) NZ260471A (sl)
TW (1) TW289021B (sl)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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DK0573848T3 (da) * 1992-06-12 1998-08-10 Hoechst Ag Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler
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US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
DE19845403B4 (de) 1998-10-02 2005-02-10 Aventis Pharma Deutschland Gmbh Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
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US6458851B1 (en) * 1998-12-23 2002-10-01 G. D. Searle, Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
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NZ512532A (en) * 1998-12-23 2003-12-19 G Combinations for treating cardiovascular diseases like hypercholesterolemia and atherosclerosis
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DE19941764A1 (de) * 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
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US6624155B2 (en) * 2001-05-01 2003-09-23 Board Of Trustees Of The University Of Arkansas Hybrid cholinergic agents and compositions
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CA3158181A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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CN114786772B (zh) 2019-12-04 2024-04-09 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
PE20230234A1 (es) 2019-12-04 2023-02-07 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar
PT4069360T (pt) 2019-12-04 2024-03-06 Albireo Ab Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
AR120683A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzoti(di)azepina y su uso como ácido biliar
TW202134221A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻二氮呯化合物及其作為膽酸調節劑之用途
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
EP4188541A1 (en) 2020-08-03 2023-06-07 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
KR102587117B1 (ko) 2020-10-09 2023-10-10 포리프라스틱 가부시키가이샤 폴리아세탈 수지 조성물 및 자동차 부품
JP7078687B2 (ja) 2020-10-09 2022-05-31 ポリプラスチックス株式会社 ポリアセタール樹脂組成物及び自動車部品
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2023203248A1 (en) 2022-04-22 2023-10-26 Albireo Ab Subcutaneous administration of an asbt inhibitor
US20230398125A1 (en) 2022-06-09 2023-12-14 Albireo Ab Treating hepatitis
US20240067617A1 (en) 2022-07-05 2024-02-29 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US20240207286A1 (en) 2022-12-09 2024-06-27 Albireo Ab Asbt inhibitors in the treatment of renal diseases

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Also Published As

Publication number Publication date
HUT67574A (en) 1995-04-28
CA2123052A1 (en) 1994-11-09
CA2123052C (en) 2005-04-26
IL109580A (en) 1999-03-12
EP0624594A2 (de) 1994-11-17
DE59408602D1 (de) 1999-09-16
IL109580A0 (en) 1994-08-26
KR100333151B1 (ko) 2002-09-04
JPH072891A (ja) 1995-01-06
ATE183191T1 (de) 1999-08-15
ES2136677T3 (es) 1999-12-01
NO941680D0 (no) 1994-05-06
TW289021B (sl) 1996-10-21
EP0624594B1 (de) 1999-08-11
AU6194994A (en) 1994-11-10
AU673419B2 (en) 1996-11-07
JP3424978B2 (ja) 2003-07-07
NZ260471A (en) 1995-04-27
GR3031541T3 (en) 2000-01-31
FI942077A (fi) 1994-11-09
NO941680L (no) 1994-11-09
CZ289209B6 (cs) 2001-12-12
DK0624594T3 (da) 1999-12-13
US5610151A (en) 1997-03-11
CZ113794A3 (en) 1994-11-16
FI942077A0 (fi) 1994-05-05
HU9401408D0 (en) 1994-08-29
EP0624594A3 (de) 1996-05-01

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