NO303541B1 - Substituerte bifenylpyridoner og deres anvendelse til fremstilling av legemidler - Google Patents

Substituerte bifenylpyridoner og deres anvendelse til fremstilling av legemidler Download PDF

Info

Publication number
NO303541B1
NO303541B1 NO924172A NO924172A NO303541B1 NO 303541 B1 NO303541 B1 NO 303541B1 NO 924172 A NO924172 A NO 924172A NO 924172 A NO924172 A NO 924172A NO 303541 B1 NO303541 B1 NO 303541B1
Authority
NO
Norway
Prior art keywords
stands
alkyl
alkoxy
formula
oxo
Prior art date
Application number
NO924172A
Other languages
English (en)
Norwegian (no)
Other versions
NO924172D0 (no
NO924172L (no
Inventor
Matthias Mueller-Gliemann
Martin Beuck
Stanislav Kazda
Johannes-Peter Stasch
Andreas Knorr
Stefan Wohlfeil
Walter Huebsch
Juergen Dressel
Peter Fey
Rudolf Hanko
Thomas Kromer
Ulrich Mueller
Siegfried Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO924172D0 publication Critical patent/NO924172D0/no
Publication of NO924172L publication Critical patent/NO924172L/no
Publication of NO303541B1 publication Critical patent/NO303541B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO924172A 1991-11-12 1992-10-29 Substituerte bifenylpyridoner og deres anvendelse til fremstilling av legemidler NO303541B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (3)

Publication Number Publication Date
NO924172D0 NO924172D0 (no) 1992-10-29
NO924172L NO924172L (no) 1993-05-14
NO303541B1 true NO303541B1 (no) 1998-07-27

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
NO924172A NO303541B1 (no) 1991-11-12 1992-10-29 Substituerte bifenylpyridoner og deres anvendelse til fremstilling av legemidler

Country Status (23)

Country Link
US (2) US5356911A (cs)
EP (1) EP0542059B1 (cs)
JP (1) JPH05255258A (cs)
KR (1) KR930010030A (cs)
CN (1) CN1038935C (cs)
AT (1) ATE135700T1 (cs)
AU (1) AU659235B2 (cs)
CA (1) CA2082306A1 (cs)
CZ (1) CZ281937B6 (cs)
DE (2) DE4221583A1 (cs)
DK (1) DK0542059T3 (cs)
ES (1) ES2086046T3 (cs)
FI (1) FI925100L (cs)
GR (1) GR3019398T3 (cs)
HU (1) HUT67018A (cs)
IL (1) IL103688A (cs)
MX (1) MX9206305A (cs)
MY (1) MY109880A (cs)
NO (1) NO303541B1 (cs)
NZ (1) NZ245073A (cs)
RU (1) RU2100350C1 (cs)
SK (1) SK338092A3 (cs)
TW (1) TW218874B (cs)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
TW418204B (en) * 1997-03-28 2001-01-11 Dev Center Biotechnology Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
GB0022483D0 (en) * 2000-09-13 2000-11-01 Eisai Co Ltd 1 2 Dihydropyridine compounds manufacturing method thereof and use thereof
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
CA2469435A1 (en) * 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
OA12771A (en) * 2002-02-14 2006-07-04 Pharmacia Corp Substituted pyridinones as modulators of P38 map kinase.
AU2004236249A1 (en) * 2003-04-30 2004-11-18 The Institutes Of Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1B
MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1844043A2 (en) * 2004-11-18 2007-10-17 The Institutes for Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids for the treatment of diabetes
RU2423351C2 (ru) * 2004-12-16 2011-07-10 Вертекс Фармасьютикалз Инкорпорейтед Пирид-2-оны, применимые как ингибиторы протеинкиназ семейства тес для лечения воспалительных, пролиферативных и иммунологически-опосредованных заболеваний
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
US7786130B2 (en) 2005-08-29 2010-08-31 Vertex Pharmaceuticals Incorporated Pyridones useful as inhibitors of kinases
EP1919891B1 (en) * 2005-08-29 2012-03-07 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
CA2620631A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
PT2200985E (pt) 2007-09-14 2011-07-21 Ortho Mcneil Janssen Pharm 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
RS51660B (sr) 2007-09-14 2011-10-31 Ortho-Mcneil-Janssen Pharmaceuticals Inc. 1`,3`-disupstituisani-4-fenil-3,4,5,6-tetrahidro-2h, 1`h-[1,4`] bipiridinil-2`-oni
ES2409215T3 (es) 2007-09-14 2013-06-25 Janssen Pharmaceuticals, Inc. 4-fenil-1H-piridin-2-onas 1-3-disustituidas
US8785486B2 (en) * 2007-11-14 2014-07-22 Janssen Pharmaceuticals, Inc. Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
ES2466341T3 (es) 2008-10-16 2014-06-10 Janssen Pharmaceuticals, Inc. Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
WO2010130424A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MX2011011962A (es) 2009-05-12 2012-02-28 Janssen Pharmaceuticals Inc Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2).
KR101445946B1 (ko) * 2009-11-06 2014-09-29 에르피오 세러퓨틱스 인코포레이티드 프롤릴 히드록실라아제 저해제
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP5852664B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
NO2794597T3 (cs) * 2011-12-21 2018-04-14
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
CN106061504B (zh) 2014-01-21 2019-09-06 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
AU2015362422B2 (en) 2014-12-10 2019-11-14 Ono Pharmaceutical Co., Ltd. Dihydroindolizinone derivative
US10322156B2 (en) * 2016-07-07 2019-06-18 Herbalife International Of America, Inc. Methods of treatment using purified (decolorized) aloe vera leaf dry juice
CA3206499A1 (en) 2021-02-02 2022-08-11 Liminal Biosciences Limited Gpr84 antagonists and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0424317A3 (en) 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0435827A3 (en) 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
CA2037630C (en) 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
AU653734B2 (en) * 1990-06-19 1994-10-13 Meiji Seika Kabushiki Kaisha Substituted 4-biphenylmethoxypyridine derivatives
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine

Also Published As

Publication number Publication date
CZ281937B6 (cs) 1997-04-16
IL103688A0 (en) 1993-04-04
JPH05255258A (ja) 1993-10-05
IL103688A (en) 1997-02-18
US5599823A (en) 1997-02-04
KR930010030A (ko) 1993-06-21
MX9206305A (es) 1993-05-01
ES2086046T3 (es) 1996-06-16
AU659235B2 (en) 1995-05-11
US5356911A (en) 1994-10-18
CN1072180A (zh) 1993-05-19
TW218874B (cs) 1994-01-11
SK279433B6 (sk) 1998-11-04
HU9203552D0 (en) 1993-01-28
FI925100A7 (fi) 1993-05-13
EP0542059B1 (de) 1996-03-20
DE59205752D1 (de) 1996-04-25
FI925100L (fi) 1993-05-13
RU2100350C1 (ru) 1997-12-27
AU2823292A (en) 1993-05-13
SK338092A3 (en) 1998-11-04
CZ338092A3 (en) 1993-09-15
ATE135700T1 (de) 1996-04-15
FI925100A0 (fi) 1992-11-10
NZ245073A (en) 1996-02-27
CA2082306A1 (en) 1993-05-12
GR3019398T3 (en) 1996-06-30
HUT67018A (en) 1995-01-30
EP0542059A1 (de) 1993-05-19
NO924172D0 (no) 1992-10-29
NO924172L (no) 1993-05-14
MY109880A (en) 1997-09-30
DK0542059T3 (da) 1996-07-22
DE4221583A1 (de) 1993-05-13
CN1038935C (zh) 1998-07-01

Similar Documents

Publication Publication Date Title
NO303541B1 (no) Substituerte bifenylpyridoner og deres anvendelse til fremstilling av legemidler
US5254543A (en) Sulphonylbenzyl-substituted pyridones which are angiotension II receptor antagonists
HUT70485A (en) Substituted mono- and bipyridyl-methyl-pyridone derivatives and process for producing them
SK15294A3 (en) Heterocyclic substituted derivatives of phenyl-cyclohexane carboxyle acid
CZ72393A3 (en) Sulfonylbenzyl-substituted benzopyridones and pyridopyridones
HUT62576A (en) Process for producing substituted imidazolylpropenoic acid derivatives and pharmaceutical compositions comprising such compounds
JPH09506102A (ja) 双環式化合物−誘導体、の製造及び使用
US5407942A (en) Biphenylmethyl-substituted pyridones
EP0432737A1 (en) Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension
US5527809A (en) Substituted imidazo[4,5-b]pyridines and benzimidazoles
US5294633A (en) Imidazolyl-propenoic acid derivatives
EP0610697B1 (de) Imidazolyl-substituierte Phenylessigsäureprolinamide
US5708003A (en) Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives
DE4301900A1 (de) 2-Oxochinolin-1-yl-methylphenylessigsäurederivate
JPH0748369A (ja) 置換モノピリジルメチルおよびビピリジルメチル誘導体
SK34993A3 (en) Propenoyl-imidazole derivatives
US5576342A (en) Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives
NZ260163A (en) Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives, and pharmaceutical compositions thereof
CZ15993A3 (en) Sulfonylbenzyl-substituted derivatives of imidazolylpropenoic acid
US5364942A (en) Sulphonylbenzyl-substituted imidazopyridines
JPH06329668A (ja) ピリジニルメチル−置換されたピリジン類およびピリドン類
US5530016A (en) Substituted 2,4-imidazolidinediones
SK14493A3 (en) Sulfonylbenzyl substituted imidazoles
SK27593A3 (en) Cycloalkyl and heterocyclyl substituted derivatives of imidazolylpropenoic acid
JPH0753550A (ja) スルホニルベンジル−置換されたベンズイミダゾール類、それらの製造方法および薬品におけるそれらの使用

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN APRIL 2002