NO301747B1 - Fremgangsmåte for å fremstille aktivert protein C (APC) - Google Patents
Fremgangsmåte for å fremstille aktivert protein C (APC) Download PDFInfo
- Publication number
- NO301747B1 NO301747B1 NO885109A NO885109A NO301747B1 NO 301747 B1 NO301747 B1 NO 301747B1 NO 885109 A NO885109 A NO 885109A NO 885109 A NO885109 A NO 885109A NO 301747 B1 NO301747 B1 NO 301747B1
- Authority
- NO
- Norway
- Prior art keywords
- apc
- protein
- experiments
- plasma
- thrombin
- Prior art date
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/121,702 US5084274A (en) | 1987-11-17 | 1987-11-17 | Inhibition of arterial thrombotic occlusion or thromboembolism |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO885109D0 NO885109D0 (no) | 1988-11-16 |
| NO885109L NO885109L (no) | 1989-05-18 |
| NO301747B1 true NO301747B1 (no) | 1997-12-08 |
Family
ID=22398288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO885109A NO301747B1 (no) | 1987-11-17 | 1988-11-16 | Fremgangsmåte for å fremstille aktivert protein C (APC) |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5084274A (fr) |
| EP (1) | EP0318201B1 (fr) |
| JP (1) | JP2766986B2 (fr) |
| AT (1) | ATE135234T1 (fr) |
| CA (1) | CA1330036C (fr) |
| DE (1) | DE3855096T2 (fr) |
| DK (1) | DK175704B1 (fr) |
| ES (1) | ES2086301T3 (fr) |
| FI (1) | FI104790B (fr) |
| GR (1) | GR3020036T3 (fr) |
| NO (1) | NO301747B1 (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| GB8819607D0 (en) * | 1988-08-17 | 1988-09-21 | Wellcome Found | Novel combination |
| DE69032029T2 (de) * | 1989-12-29 | 1998-08-20 | Zymogenetics, Inc., Seattle, Wash. | Hybrides protein c |
| US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
| US5571786A (en) * | 1990-08-16 | 1996-11-05 | Immuno Aktiengesellschaft | Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation |
| FR2671973A1 (fr) * | 1991-01-25 | 1992-07-31 | Fondation Nale Transfusion San | Utilisation de la proteine c activee comme agent anti-agregant plaquettaire. |
| EP0580685B1 (fr) * | 1991-04-16 | 1996-01-03 | Roche Diagnostics GmbH | Unite de conditionnement pharmaceutique contenant des activateurs de plasminogene destines a etre administres en plusieurs bols |
| AT397615B (de) * | 1991-05-14 | 1994-05-25 | Immuno Ag | Arzneimittel enthaltend protein c |
| AT402262B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Arzneimittel enthaltend aktiviertes protein c |
| AT402263B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz |
| AT395596B (de) * | 1991-06-20 | 1993-01-25 | Immuno Ag | Verfahren zur herstellung von aktiviertem protein c |
| WO1993009807A1 (fr) * | 1991-11-18 | 1993-05-27 | The Scripps Research Institute | Procedes d'inhibition de la thrombose par elevation des taux de proteine c activee endogene dans la circulation |
| JPH05271098A (ja) * | 1992-03-26 | 1993-10-19 | Teijin Ltd | 活性化プロテインｃを有効成分とする抗血小板剤 |
| DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
| US5520912A (en) * | 1993-07-02 | 1996-05-28 | Immuno Aktiengesellschaft | Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen |
| JP3043558B2 (ja) * | 1993-10-29 | 2000-05-22 | 財団法人化学及血清療法研究所 | ヒト活性化プロテインｃ調製物及びその製法 |
| US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
| JP4067117B2 (ja) * | 1995-06-09 | 2008-03-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 選択性スロンビン抑制剤としてのブラジキニン同族体 |
| TR199902335T2 (xx) * | 1997-03-24 | 2000-01-21 | Eli Lilly And Company | Vask�ler bozukluklar�n tedavisi. |
| US6982249B1 (en) | 1997-04-23 | 2006-01-03 | The Regents Of The University Of Michigan | Bradykinin analogs as selective inhibitors of cell activation |
| JP2002502421A (ja) * | 1997-06-05 | 2002-01-22 | イーライ・リリー・アンド・カンパニー | 血栓障害の処置方法 |
| HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| US6953568B1 (en) | 1998-08-25 | 2005-10-11 | Oklahoma Medical Research Foundation | Targeting of molecules to large vessel endothelium using EPCR |
| CN1326357A (zh) | 1998-11-23 | 2001-12-12 | 伊莱利利公司 | 治疗镰刀形红细胞贫血病及地中海贫血病的方法 |
| AU2001238034A1 (en) * | 2000-02-04 | 2001-08-14 | The Scripps Research Institute | Neuroprotective, antithrombotic and anti-inflammatory uses of activated protein c (apc) |
| US7204981B2 (en) | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
| US7087578B2 (en) | 2000-05-24 | 2006-08-08 | Eli Lilly And Company | Formulations and methods for treating hypercoagulable states |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| US20040122354A1 (en) * | 2002-09-05 | 2004-06-24 | Semba Charles P. | Infusion catheter having an integrated doppler transducer |
| WO2004056309A2 (fr) | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Activite neuroprotectrice de la proteine c activee independante de son activite anticoagulante |
| US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
| US9192657B2 (en) | 2003-07-08 | 2015-11-24 | The Scripps Research Institute | Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity |
| WO2005007820A2 (fr) | 2003-07-08 | 2005-01-27 | The Scripps Research Institute | Variants de proteine c activee avec activite cytoprotectrice normale mais avec activite anticoagulante reduite |
| WO2006014839A2 (fr) * | 2004-07-23 | 2006-02-09 | The University Of Rochester | La proteine c activee inhibe les effets secondaires de l'activateur de plasminogene dans le cerveau |
| JP2008531582A (ja) | 2005-02-24 | 2008-08-14 | ディフュージョン・ファーマシューティカルズ・エルエルシー | トランスカロテノイド、それらの合成、配合、および使用 |
| US7785857B2 (en) * | 2006-08-31 | 2010-08-31 | Saint Louis University | Protein C variant |
| CA2668187A1 (fr) * | 2006-10-31 | 2008-06-19 | The Scripps Research Institute | Schema posologique de proteine c activee et de ses variants presentant une activite anticoagulante reduite |
| EA200970944A1 (ru) | 2007-04-13 | 2010-06-30 | Диффьюжн Фармасьютикалз Ллс | Применение биполярных транскаротиноидов в качестве предварительного лечения при лечении заболевания периферических сосудов |
| CA2765697C (fr) | 2009-06-22 | 2019-11-12 | Diffusion Pharmaceuticals Llc | Composes ameliorant la diffusion et leur utilisation seuls ou avec des thrombolytiques |
| EP2575487B1 (fr) | 2010-06-02 | 2017-10-18 | Diffusion Pharmaceuticals Llc | Formes pharmaceutiques orales à base de caroténoïdes trans bipolaires |
| EP2869833B1 (fr) | 2012-07-04 | 2018-04-04 | ZZ Biotech LLC. | Protéine c activée pour traitement de troubles cutanés inflammatoires |
| WO2015157791A1 (fr) | 2014-04-16 | 2015-10-22 | The University Of Sydney | Traitement de cicatrices cutanées anormales |
| KR20230014850A (ko) | 2016-03-24 | 2023-01-30 | 디퓨젼 파마슈티컬즈 엘엘씨 | 암을 치료하기 위한, 화학 요법 및 방사선 요법과의 양극성 트랜스 카로티노이드의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| JPS6011427A (ja) * | 1983-06-29 | 1985-01-21 | Green Cross Corp:The | 血栓溶解性蛋白の疾患局所親和性向上方法 |
| GB8319538D0 (en) * | 1983-07-20 | 1983-08-24 | Beecham Group Plc | Compounds |
| DE3584902D1 (de) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren. |
| AU595173B2 (en) * | 1985-01-08 | 1990-03-29 | General Hospital Corporation, The | Method and use for site-specific activation of substances |
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| CA1341228C (fr) * | 1985-06-27 | 2001-05-15 | Mark J. Murray | Expression de la proteine c |
| US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| US4929602A (en) * | 1987-11-25 | 1990-05-29 | Scripps Clinic And Research Foundation | Method of inhibiting platelet dependent arterial thrombosis |
-
1987
- 1987-11-17 US US07/121,702 patent/US5084274A/en not_active Expired - Lifetime
-
1988
- 1988-11-15 CA CA000583138A patent/CA1330036C/fr not_active Expired - Lifetime
- 1988-11-16 NO NO885109A patent/NO301747B1/no not_active IP Right Cessation
- 1988-11-16 AT AT88310800T patent/ATE135234T1/de not_active IP Right Cessation
- 1988-11-16 DK DK198806400A patent/DK175704B1/da not_active IP Right Cessation
- 1988-11-16 DE DE3855096T patent/DE3855096T2/de not_active Expired - Lifetime
- 1988-11-16 ES ES88310800T patent/ES2086301T3/es not_active Expired - Lifetime
- 1988-11-16 EP EP88310800A patent/EP0318201B1/fr not_active Expired - Lifetime
- 1988-11-17 JP JP63292222A patent/JP2766986B2/ja not_active Expired - Lifetime
- 1988-11-17 FI FI885331A patent/FI104790B/fi not_active IP Right Cessation
-
1991
- 1991-10-25 US US07/782,817 patent/US5350578A/en not_active Expired - Lifetime
-
1996
- 1996-05-27 GR GR960401399T patent/GR3020036T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5084274A (en) | 1992-01-28 |
| ATE135234T1 (de) | 1996-03-15 |
| FI104790B (fi) | 2000-04-14 |
| DK640088D0 (da) | 1988-11-16 |
| EP0318201A3 (en) | 1990-02-07 |
| DE3855096T2 (de) | 1996-07-25 |
| DK640088A (da) | 1989-05-18 |
| GR3020036T3 (en) | 1996-08-31 |
| DE3855096D1 (de) | 1996-04-18 |
| EP0318201A2 (fr) | 1989-05-31 |
| NO885109D0 (no) | 1988-11-16 |
| EP0318201B1 (fr) | 1996-03-13 |
| JPH01238536A (ja) | 1989-09-22 |
| CA1330036C (fr) | 1994-06-07 |
| JP2766986B2 (ja) | 1998-06-18 |
| US5350578A (en) | 1994-09-27 |
| FI885331A (fi) | 1989-05-18 |
| ES2086301T3 (es) | 1996-07-01 |
| NO885109L (no) | 1989-05-18 |
| DK175704B1 (da) | 2005-01-24 |
| FI885331A0 (fi) | 1988-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |