NO301479B1 - Trisubstituerte pyrimido £5,4-d| pyrimidiner for modulering av multimedikamentresistens, legemidler som inneholder disse forbindelser og fremgangsmåter ved fremstilling av dem - Google Patents

Trisubstituerte pyrimido £5,4-d| pyrimidiner for modulering av multimedikamentresistens, legemidler som inneholder disse forbindelser og fremgangsmåter ved fremstilling av dem

Info

Publication number
NO301479B1
NO301479B1 NO942853A NO942853A NO301479B1 NO 301479 B1 NO301479 B1 NO 301479B1 NO 942853 A NO942853 A NO 942853A NO 942853 A NO942853 A NO 942853A NO 301479 B1 NO301479 B1 NO 301479B1
Authority
NO
Norway
Prior art keywords
pyrimidines
preparing
compounds
methods
multidrug resistance
Prior art date
Application number
NO942853A
Other languages
English (en)
Norwegian (no)
Other versions
NO942853L (no
NO942853D0 (ref
Inventor
Armin Heckel
Uwe Bamberger
Annerose Mauz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO942853D0 publication Critical patent/NO942853D0/no
Publication of NO942853L publication Critical patent/NO942853L/no
Publication of NO301479B1 publication Critical patent/NO301479B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO942853A 1993-08-02 1994-08-01 Trisubstituerte pyrimido £5,4-d| pyrimidiner for modulering av multimedikamentresistens, legemidler som inneholder disse forbindelser og fremgangsmåter ved fremstilling av dem NO301479B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4325900A DE4325900A1 (de) 1993-08-02 1993-08-02 Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (3)

Publication Number Publication Date
NO942853D0 NO942853D0 (ref) 1994-08-01
NO942853L NO942853L (no) 1995-02-03
NO301479B1 true NO301479B1 (no) 1997-11-03

Family

ID=6494272

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942853A NO301479B1 (no) 1993-08-02 1994-08-01 Trisubstituerte pyrimido £5,4-d| pyrimidiner for modulering av multimedikamentresistens, legemidler som inneholder disse forbindelser og fremgangsmåter ved fremstilling av dem

Country Status (22)

Country Link
US (1) US5618814A (ref)
EP (1) EP0645390A1 (ref)
JP (1) JPH0789963A (ref)
KR (1) KR950005828A (ref)
CN (1) CN1041091C (ref)
AU (1) AU683888B2 (ref)
BG (1) BG98931A (ref)
CA (1) CA2129179A1 (ref)
CZ (1) CZ184594A3 (ref)
DE (1) DE4325900A1 (ref)
EE (1) EE9400255A (ref)
FI (1) FI943574A7 (ref)
HU (1) HUT70957A (ref)
IL (1) IL110509A (ref)
NO (1) NO301479B1 (ref)
NZ (1) NZ264133A (ref)
PL (1) PL304512A1 (ref)
RO (1) RO113557B1 (ref)
RU (1) RU94028278A (ref)
SK (1) SK91594A3 (ref)
TW (1) TW251286B (ref)
ZA (1) ZA945689B (ref)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608588A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
CN1984660B (zh) * 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CN115650827B (zh) * 2022-10-27 2024-03-15 戊言医药科技（上海）有限公司 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069211D1 (en) * 1979-07-03 1984-10-25 Thomae Gmbh Dr K 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them
DE2931573A1 (de) * 1979-08-03 1981-02-26 Thomae Gmbh Dr K Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3833392A1 (de) * 1988-10-01 1990-04-05 Thomae Gmbh Dr K Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI943574A7 (fi) 1995-02-03
HUT70957A (en) 1995-11-28
BG98931A (en) 1995-09-29
CA2129179A1 (en) 1995-02-03
EP0645390A1 (de) 1995-03-29
NO942853L (no) 1995-02-03
ZA945689B (en) 1996-02-01
FI943574A0 (fi) 1994-08-01
AU6881394A (en) 1995-02-09
NZ264133A (en) 1996-05-28
CN1041091C (zh) 1998-12-09
RO113557B1 (ro) 1998-08-28
IL110509A (en) 1998-01-04
HU9402253D0 (en) 1994-09-28
US5618814A (en) 1997-04-08
IL110509A0 (en) 1994-10-21
SK91594A3 (en) 1995-04-12
DE4325900A1 (de) 1995-02-09
TW251286B (ref) 1995-07-11
AU683888B2 (en) 1997-11-27
EE9400255A (et) 1996-02-15
RU94028278A (ru) 1996-08-27
CN1106405A (zh) 1995-08-09
PL304512A1 (en) 1995-02-06
KR950005828A (ko) 1995-03-20
CZ184594A3 (en) 1995-02-15
NO942853D0 (ref) 1994-08-01
JPH0789963A (ja) 1995-04-04

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