NO301374B1 - Fremgangsmåte for fremstilling av et <alfa>2-antiplasmin monoklonalt antistoff - Google Patents

Fremgangsmåte for fremstilling av et <alfa>2-antiplasmin monoklonalt antistoff Download PDF

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Publication number
NO301374B1
NO301374B1 NO904294A NO904294A NO301374B1 NO 301374 B1 NO301374 B1 NO 301374B1 NO 904294 A NO904294 A NO 904294A NO 904294 A NO904294 A NO 904294A NO 301374 B1 NO301374 B1 NO 301374B1
Authority
NO
Norway
Prior art keywords
antiplasmin
antibody
clot
fibrin
plasmin
Prior art date
Application number
NO904294A
Other languages
English (en)
Norwegian (no)
Other versions
NO904294D0 (no
NO904294L (no
Inventor
Guy L Reed
Gary R Matsueda
Edgar Haber
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of NO904294D0 publication Critical patent/NO904294D0/no
Publication of NO904294L publication Critical patent/NO904294L/no
Publication of NO301374B1 publication Critical patent/NO301374B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Surgical Instruments (AREA)
  • External Artificial Organs (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
NO904294A 1988-04-04 1990-10-03 Fremgangsmåte for fremstilling av et <alfa>2-antiplasmin monoklonalt antistoff NO301374B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17722288A 1988-04-04 1988-04-04
PCT/US1989/001065 WO1989009817A1 (en) 1988-04-04 1989-03-15 Composition and method for acceleration of clot lysis

Publications (3)

Publication Number Publication Date
NO904294D0 NO904294D0 (no) 1990-10-03
NO904294L NO904294L (no) 1990-12-04
NO301374B1 true NO301374B1 (no) 1997-10-20

Family

ID=22647707

Family Applications (1)

Application Number Title Priority Date Filing Date
NO904294A NO301374B1 (no) 1988-04-04 1990-10-03 Fremgangsmåte for fremstilling av et <alfa>2-antiplasmin monoklonalt antistoff

Country Status (15)

Country Link
EP (1) EP0336693B1 (da)
JP (1) JP2871775B2 (da)
KR (1) KR100194113B1 (da)
AT (1) ATE114480T1 (da)
AU (1) AU628041B2 (da)
CA (1) CA1341377C (da)
DE (1) DE68919504T2 (da)
DK (1) DK174062B1 (da)
ES (1) ES2064435T3 (da)
FI (1) FI102812B (da)
GR (1) GR3015182T3 (da)
HU (1) HU207349B (da)
NO (1) NO301374B1 (da)
WO (1) WO1989009817A1 (da)
ZA (1) ZA892464B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5357042A (en) * 1984-04-23 1994-10-18 The General Hospital Corporation Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
JPH02268694A (ja) * 1989-04-07 1990-11-02 Teijin Ltd 血栓溶解剤
CA2266339A1 (en) * 1996-09-20 1998-03-26 The General Hospital Corporation Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin
US6524675B1 (en) 1999-05-13 2003-02-25 3M Innovative Properties Company Adhesive-back articles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0735340B2 (ja) * 1985-05-23 1995-04-19 帝人株式会社 血栓溶解促進剤
ATE142502T1 (de) * 1986-05-15 1996-09-15 Univ Emory Injizierbares arzneimittel zum schutz vor gewebebeschädigung durch ischemie

Also Published As

Publication number Publication date
DK240190D0 (da) 1990-10-04
EP0336693A2 (en) 1989-10-11
GR3015182T3 (en) 1995-05-31
DE68919504T2 (de) 1995-06-29
KR900700129A (ko) 1990-08-11
DK240190A (da) 1990-10-04
EP0336693B1 (en) 1994-11-30
AU3284589A (en) 1989-11-03
ES2064435T3 (es) 1995-02-01
EP0336693A3 (en) 1990-03-21
NO904294D0 (no) 1990-10-03
CA1341377C (en) 2002-07-16
ATE114480T1 (de) 1994-12-15
JP2871775B2 (ja) 1999-03-17
HUT56394A (en) 1991-08-28
JPH03504717A (ja) 1991-10-17
FI102812B1 (fi) 1999-02-26
HU207349B (en) 1993-03-29
AU628041B2 (en) 1992-09-10
WO1989009817A1 (en) 1989-10-19
ZA892464B (en) 1989-12-27
KR100194113B1 (ko) 1999-06-15
HU892304D0 (en) 1991-07-29
DK174062B1 (da) 2002-05-13
DE68919504D1 (de) 1995-01-12
FI102812B (fi) 1999-02-26
NO904294L (no) 1990-12-04
FI904867A0 (fi) 1990-10-03

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