NO300846B1 - Nye, 2-substituerte indan-2-karboksyalkylderivater anvendbare som inhibitorer av enkefalinase og ACE - Google Patents
Nye, 2-substituerte indan-2-karboksyalkylderivater anvendbare som inhibitorer av enkefalinase og ACE Download PDFInfo
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- NO300846B1 NO300846B1 NO923745A NO923745A NO300846B1 NO 300846 B1 NO300846 B1 NO 300846B1 NO 923745 A NO923745 A NO 923745A NO 923745 A NO923745 A NO 923745A NO 300846 B1 NO300846 B1 NO 300846B1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- QQWYQAQQADNEIC-RVDMUPIBSA-N tert-butyl [(z)-[cyano(phenyl)methylidene]amino] carbonate Chemical compound CC(C)(C)OC(=O)O\N=C(/C#N)C1=CC=CC=C1 QQWYQAQQADNEIC-RVDMUPIBSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76728991A | 1991-09-27 | 1991-09-27 | |
| US92948292A | 1992-08-20 | 1992-08-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO923745D0 NO923745D0 (no) | 1992-09-25 |
| NO923745L NO923745L (no) | 1993-03-29 |
| NO300846B1 true NO300846B1 (no) | 1997-08-04 |
Family
ID=27117892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO923745A NO300846B1 (no) | 1991-09-27 | 1992-09-25 | Nye, 2-substituerte indan-2-karboksyalkylderivater anvendbare som inhibitorer av enkefalinase og ACE |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0534396B1 (fi) |
| JP (1) | JP3173674B2 (fi) |
| KR (1) | KR100271242B1 (fi) |
| AT (1) | ATE143972T1 (fi) |
| AU (1) | AU657793B2 (fi) |
| CA (1) | CA2079143C (fi) |
| DE (1) | DE69214397T2 (fi) |
| DK (1) | DK0534396T3 (fi) |
| ES (1) | ES2095380T3 (fi) |
| FI (1) | FI101302B1 (fi) |
| GR (1) | GR3021420T3 (fi) |
| HU (1) | HU214821B (fi) |
| IL (1) | IL103283A (fi) |
| NO (1) | NO300846B1 (fi) |
| NZ (1) | NZ244462A (fi) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2078758C (en) * | 1991-09-27 | 2003-12-09 | Alan M. Warshawsky | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5646276A (en) * | 1992-05-13 | 1997-07-08 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| WO1994004531A1 (en) * | 1992-08-24 | 1994-03-03 | Merrell Dow Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| JPH09500113A (ja) * | 1993-06-30 | 1997-01-07 | チバ−ガイギー アクチェンゲゼルシャフト | エンケファリナーゼ及びａｃｅのインヒビターとして有用な抗高血圧性三環式アゼピン誘導体 |
| US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
| US5594106A (en) * | 1993-08-23 | 1997-01-14 | Immunex Corporation | Inhibitors of TNF-α secretion |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| EP0750631B1 (en) * | 1994-02-14 | 2000-04-05 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
| WO1995021857A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| CN1069317C (zh) * | 1994-02-14 | 2001-08-08 | 默里尔药物公司 | 用作脑啡肽酶抑制剂的新的1,2－二氢化茚－2－巯基乙酰胺二硫化物衍生物 |
| US5616775A (en) * | 1994-05-05 | 1997-04-01 | Bristol-Myers Squibb Co. | Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring |
| HU227675B1 (en) * | 1994-12-21 | 2011-11-28 | Aventisub Ii Inc | Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
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| US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
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| ATE158303T1 (de) * | 1990-12-21 | 1997-10-15 | Merrell Pharma Inc | Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften |
| CA2078758C (en) * | 1991-09-27 | 2003-12-09 | Alan M. Warshawsky | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
-
1992
- 1992-09-22 AU AU25246/92A patent/AU657793B2/en not_active Ceased
- 1992-09-23 EP EP92116264A patent/EP0534396B1/en not_active Expired - Lifetime
- 1992-09-23 DE DE69214397T patent/DE69214397T2/de not_active Expired - Lifetime
- 1992-09-23 DK DK92116264.0T patent/DK0534396T3/da active
- 1992-09-23 ES ES92116264T patent/ES2095380T3/es not_active Expired - Lifetime
- 1992-09-23 AT AT92116264T patent/ATE143972T1/de not_active IP Right Cessation
- 1992-09-23 NZ NZ244462A patent/NZ244462A/xx unknown
- 1992-09-24 IL IL10328392A patent/IL103283A/en not_active IP Right Cessation
- 1992-09-25 FI FI924310A patent/FI101302B1/fi not_active IP Right Cessation
- 1992-09-25 NO NO923745A patent/NO300846B1/no not_active IP Right Cessation
- 1992-09-25 JP JP28066892A patent/JP3173674B2/ja not_active Expired - Lifetime
- 1992-09-25 CA CA002079143A patent/CA2079143C/en not_active Expired - Lifetime
- 1992-09-25 HU HU9203075A patent/HU214821B/hu not_active IP Right Cessation
- 1992-09-26 KR KR1019920017616A patent/KR100271242B1/ko not_active IP Right Cessation
-
1996
- 1996-10-23 GR GR960402792T patent/GR3021420T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI101302B (fi) | 1998-05-29 |
| EP0534396B1 (en) | 1996-10-09 |
| DK0534396T3 (da) | 1996-11-18 |
| NO923745L (no) | 1993-03-29 |
| FI101302B1 (fi) | 1998-05-29 |
| HU214821B (hu) | 1998-06-29 |
| CA2079143A1 (en) | 1993-03-28 |
| IL103283A0 (en) | 1993-02-21 |
| GR3021420T3 (en) | 1997-01-31 |
| KR930006028A (ko) | 1993-04-20 |
| NZ244462A (en) | 1994-08-26 |
| EP0534396A3 (en) | 1993-06-09 |
| DE69214397D1 (de) | 1996-11-14 |
| EP0534396A2 (en) | 1993-03-31 |
| KR100271242B1 (ko) | 2001-02-01 |
| NO923745D0 (no) | 1992-09-25 |
| CA2079143C (en) | 2004-03-16 |
| HU9203075D0 (en) | 1992-12-28 |
| IL103283A (en) | 1999-04-11 |
| AU657793B2 (en) | 1995-03-23 |
| DE69214397T2 (de) | 1997-03-06 |
| HUT65278A (en) | 1994-05-02 |
| JP3173674B2 (ja) | 2001-06-04 |
| AU2524692A (en) | 1993-04-01 |
| FI924310A (fi) | 1993-03-28 |
| FI924310A0 (fi) | 1992-09-25 |
| ES2095380T3 (es) | 1997-02-16 |
| ATE143972T1 (de) | 1996-10-15 |
| JPH05230060A (ja) | 1993-09-07 |
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