NO300812B1 - Fremgangsmåte for fremstilling av antitumorsubstans BE-13793C, samt biologisk ren kultur istand til å frembringe denne - Google Patents
Fremgangsmåte for fremstilling av antitumorsubstans BE-13793C, samt biologisk ren kultur istand til å frembringe denne Download PDFInfo
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- NO300812B1 NO300812B1 NO920614A NO920614A NO300812B1 NO 300812 B1 NO300812 B1 NO 300812B1 NO 920614 A NO920614 A NO 920614A NO 920614 A NO920614 A NO 920614A NO 300812 B1 NO300812 B1 NO 300812B1
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- antitumor
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- antitumor substance
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- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011426 transformation method Methods 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/625—Streptoverticillium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/908—Streptovirticillium
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9301384A SE507907C2 (sv) | 1992-02-17 | 1993-04-26 | Anläggning för kalkning av vattendrag |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7114989 | 1989-03-23 | ||
| PCT/JP1990/000812 WO1991019716A1 (fr) | 1989-03-23 | 1990-06-20 | Substance antitumorale be-13793c |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO920614D0 NO920614D0 (no) | 1992-02-17 |
| NO920614L NO920614L (no) | 1992-03-24 |
| NO300812B1 true NO300812B1 (no) | 1997-07-28 |
Family
ID=13452261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO920614A NO300812B1 (no) | 1989-03-23 | 1992-02-17 | Fremgangsmåte for fremstilling av antitumorsubstans BE-13793C, samt biologisk ren kultur istand til å frembringe denne |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5106864A (fr) |
| EP (1) | EP0388956B1 (fr) |
| JP (1) | JP3010675B2 (fr) |
| KR (1) | KR0163202B1 (fr) |
| AT (1) | ATE110727T1 (fr) |
| AU (1) | AU634247B2 (fr) |
| CA (1) | CA2012955C (fr) |
| DE (1) | DE69011913T2 (fr) |
| DK (1) | DK0388956T3 (fr) |
| ES (1) | ES2063186T3 (fr) |
| HU (1) | HU210868A9 (fr) |
| NO (1) | NO300812B1 (fr) |
| WO (1) | WO1991019716A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0528030B1 (fr) * | 1990-05-11 | 1997-09-17 | Banyu Pharmaceutical Co., Ltd. | Derive antitumoral de be-13793c |
| US5478813A (en) * | 1990-05-11 | 1995-12-26 | Banyu Pharmaceutical Co., Ltd. | Antitumor substance BE-13793C derivatives |
| US5668271A (en) * | 1991-11-29 | 1997-09-16 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives |
| US5591842A (en) * | 1991-11-29 | 1997-01-07 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives |
| US5589365A (en) * | 1991-11-29 | 1996-12-31 | Banyu Pharmaceutical Co., Ltd. | Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms |
| US5547976A (en) * | 1992-03-20 | 1996-08-20 | Burroughs Wellcome Co. | Further indole derivatives with antiviral activity |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
| US5922860A (en) * | 1994-05-09 | 1999-07-13 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyrrolocarbazole derivatives |
| US5804564A (en) * | 1994-05-09 | 1998-09-08 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyrrolocarbazole derivatives |
| JP3707075B2 (ja) * | 1994-06-13 | 2005-10-19 | 萬有製薬株式会社 | グリコシルトランスフェラーゼをコードする遺伝子及びその用途 |
| US5808060A (en) * | 1995-12-11 | 1998-09-15 | Cephalon, Inc. | Fused isoindolones |
| AU2260897A (en) * | 1996-02-07 | 1997-08-28 | Banyu Pharmaceutical Co., Ltd. | Effective production method of be-13793c |
| GB9811624D0 (en) * | 1998-05-29 | 1998-07-29 | Merck Sharp & Dohme | Therapeutic use |
| US6703373B1 (en) | 1999-09-10 | 2004-03-09 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives and antitumor agents |
| FR2845996A1 (fr) * | 2002-10-16 | 2004-04-23 | Servier Lab | Nouveaux derives de[3,4-a:3,4-c]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE102006038635B4 (de) * | 2006-08-19 | 2010-04-15 | Josip Marinic | Magnettonabnehmer für ein Saiteninstrument |
| EP3484997A4 (fr) | 2016-07-12 | 2020-07-29 | California Institute of Technology | Substrats pour croissance de cellules à haute densité et échange de métabolites |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0826037B2 (ja) * | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
-
1990
- 1990-03-20 JP JP2071543A patent/JP3010675B2/ja not_active Expired - Fee Related
- 1990-03-21 US US07/496,701 patent/US5106864A/en not_active Expired - Lifetime
- 1990-03-22 DE DE69011913T patent/DE69011913T2/de not_active Expired - Fee Related
- 1990-03-22 AT AT90105439T patent/ATE110727T1/de not_active IP Right Cessation
- 1990-03-22 ES ES90105439T patent/ES2063186T3/es not_active Expired - Lifetime
- 1990-03-22 DK DK90105439.5T patent/DK0388956T3/da active
- 1990-03-22 EP EP90105439A patent/EP0388956B1/fr not_active Expired - Lifetime
- 1990-03-23 CA CA002012955A patent/CA2012955C/fr not_active Expired - Fee Related
- 1990-06-20 AU AU58351/90A patent/AU634247B2/en not_active Ceased
- 1990-06-20 KR KR1019920700375A patent/KR0163202B1/ko not_active IP Right Cessation
- 1990-06-20 WO PCT/JP1990/000812 patent/WO1991019716A1/fr active Application Filing
-
1992
- 1992-02-17 NO NO920614A patent/NO300812B1/no unknown
- 1992-12-04 US US07/985,955 patent/US5290698A/en not_active Expired - Lifetime
-
1995
- 1995-05-23 HU HU95P/P00138P patent/HU210868A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69011913T2 (de) | 1995-02-09 |
| US5106864A (en) | 1992-04-21 |
| ATE110727T1 (de) | 1994-09-15 |
| NO920614D0 (no) | 1992-02-17 |
| NO920614L (no) | 1992-03-24 |
| HU210868A9 (en) | 1995-08-28 |
| JP3010675B2 (ja) | 2000-02-21 |
| KR920703597A (ko) | 1992-12-18 |
| AU5835190A (en) | 1992-01-07 |
| JPH0320277A (ja) | 1991-01-29 |
| DE69011913D1 (de) | 1994-10-06 |
| WO1991019716A1 (fr) | 1991-12-26 |
| DK0388956T3 (da) | 1994-11-14 |
| ES2063186T3 (es) | 1995-01-01 |
| CA2012955C (fr) | 2001-08-21 |
| EP0388956A2 (fr) | 1990-09-26 |
| KR0163202B1 (ko) | 1998-12-01 |
| US5290698A (en) | 1994-03-01 |
| EP0388956A3 (fr) | 1991-10-02 |
| AU634247B2 (en) | 1993-02-18 |
| EP0388956B1 (fr) | 1994-08-31 |
| CA2012955A1 (fr) | 1990-09-23 |
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