NO2842573T3 - - Google Patents
Info
- Publication number
- NO2842573T3 NO2842573T3 NO14188785A NO14188785A NO2842573T3 NO 2842573 T3 NO2842573 T3 NO 2842573T3 NO 14188785 A NO14188785 A NO 14188785A NO 14188785 A NO14188785 A NO 14188785A NO 2842573 T3 NO2842573 T3 NO 2842573T3
- Authority
- NO
- Norway
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11268608P | 2008-11-07 | 2008-11-07 | |
| US16487009P | 2009-03-30 | 2009-03-30 | |
| EP09825523.5A EP2365828B1 (en) | 2008-11-07 | 2009-11-06 | Monoclonal antibodies to fibroblast growth factor receptor 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2842573T3 true NO2842573T3 (cg-RX-API-DMAC10.html) | 2018-02-24 |
Family
ID=42153600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO14188785A NO2842573T3 (cg-RX-API-DMAC10.html) | 2008-11-07 | 2009-11-06 |
Country Status (20)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009100105A2 (en) * | 2008-02-04 | 2009-08-13 | Attogen Inc. | Inhibitors of oncogenic isoforms and uses thereof |
| US9260525B2 (en) | 2008-02-04 | 2016-02-16 | Xiao-Jia Chang | Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof |
| WO2012021841A2 (en) * | 2010-08-12 | 2012-02-16 | Attogen Inc. | Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof |
| DK3290052T3 (da) | 2008-11-07 | 2020-02-03 | Galaxy Biotech Llc | Monoklonale antistoffer mod fibroblastvækstfaktorreceptor 2 |
| CA2800311A1 (en) | 2010-05-11 | 2011-11-17 | Aveo Pharmaceuticals, Inc. | Anti-fgfr2 antibodies |
| JP6400470B2 (ja) | 2011-05-16 | 2018-10-03 | ジェネロン（シャンハイ）コーポレイション リミテッド | 多重特異性Ｆａｂ融合タンパク質および使用法 |
| AR088941A1 (es) | 2011-11-23 | 2014-07-16 | Bayer Ip Gmbh | Anticuerpos anti-fgfr2 y sus usos |
| MX2014007121A (es) * | 2011-12-14 | 2014-09-04 | Seattle Genetics Inc | Nuevos conjugados de principio activo-ligante (adc) y su uso. |
| MX360056B (es) | 2012-03-08 | 2018-10-19 | Janssen Vaccines & Prevention Bv | Moléculas de unión humanas que pueden unirse a los virus de la influenza b y neutralizarlos, y sus usos. |
| AU2013247645B2 (en) * | 2012-04-09 | 2019-02-14 | Daiichi Sankyo Company, Limited | Anti-FGFR2 antibody |
| WO2014089193A1 (en) * | 2012-12-04 | 2014-06-12 | Aveo Pharmaceuticals, Inc. | Anti-fgfr2 antibodies |
| CN104995512A (zh) * | 2012-12-21 | 2015-10-21 | 詹森生物科技公司 | 用于可溶性成纤维细胞生长因子受体的灵敏的多重免疫测定 |
| CN103145843B (zh) * | 2013-02-20 | 2014-10-29 | 暨南大学 | 抗成纤维细胞生长因子受体的单链抗体 |
| JP2016510751A (ja) | 2013-03-06 | 2016-04-11 | ジェネンテック， インコーポレイテッド | 抗がん剤耐性を治療及び予防する方法 |
| MX374785B (es) * | 2013-08-01 | 2025-03-06 | Five Prime Therapeutics Inc | Anticuerpos anti-fgfr2iiib afucosilados. |
| CN105792844B (zh) * | 2013-10-08 | 2021-03-02 | 第一三共株式会社 | 抗fgfr2抗体和另一药剂的组合 |
| CN103757026B (zh) * | 2013-12-20 | 2017-04-05 | 广州圣露生物技术有限公司 | FGFR2b胞外段的基因序列、多肽及其应用 |
| WO2015191986A1 (en) | 2014-06-13 | 2015-12-17 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance |
| CN104231079A (zh) * | 2014-09-12 | 2014-12-24 | 暨南大学 | 一种靶向bFGF高亲和力受体结合位点的抗体及其应用 |
| JP6887944B2 (ja) * | 2015-04-08 | 2021-06-16 | 第一三共株式会社 | 抗ｆｇｆｒ２抗体と他剤を含む組成物 |
| WO2016171107A1 (ja) * | 2015-04-20 | 2016-10-27 | 第一三共株式会社 | Ｆｇｆｒ２の検出 |
| RU2638457C2 (ru) * | 2015-09-28 | 2017-12-13 | Общество С Ограниченной Ответственностью "Онкомакс" | Антитела, специфически связывающие рецептор 1 типа фактора роста фибробластов, применение антител для лечения онкологического заболевания, способ получения антител |
| SG10201913538VA (en) * | 2015-11-23 | 2020-02-27 | Five Prime Therapeutics Inc | Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment |
| WO2017157305A1 (en) | 2016-03-15 | 2017-09-21 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| DK3624837T3 (da) | 2017-05-16 | 2025-09-29 | Five Prime Therapeutics Inc | Anti-fgfr2-antistoffer i kombination med kemoterapeutiske midler til kræftbehandling |
| CN118085076A (zh) | 2017-06-02 | 2024-05-28 | 埃博灵克斯股份有限公司 | 结合聚集蛋白聚糖的免疫球蛋白 |
| WO2019084067A1 (en) * | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | ANTI-CD117 ANTIBODIES AND METHODS OF USE |
| EP3700568A4 (en) | 2017-10-24 | 2021-11-10 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS |
| US10882915B2 (en) | 2017-10-24 | 2021-01-05 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD117+ cells |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| PE20211213A1 (es) | 2018-10-05 | 2021-07-05 | Five Prime Therapeutics Inc | Formulaciones de anticuerpos anti-fgfr2 |
| WO2020132810A1 (en) | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| JP7671275B2 (ja) | 2019-08-29 | 2025-05-01 | エランコ・ユーエス・インコーポレイテッド | 動物用の抗ｉｌ３１抗体 |
| AR120884A1 (es) * | 2019-12-24 | 2022-03-23 | Dizal Jiangsu Pharmaceutical Co Ltd | Anticuerpos anti-fgfr2b |
| CN114846029A (zh) * | 2019-12-24 | 2022-08-02 | 迪哲(江苏)医药股份有限公司 | 新颖抗fgfr2b抗体 |
| AU2021284297A1 (en) * | 2020-06-03 | 2023-02-02 | Dana-Farber Cancer Institute, Inc. | Antagonistic biparatopic antibodies that specifically bind fibroblast growth factor receptor 2 and methods of using same |
| US11866502B2 (en) | 2020-10-22 | 2024-01-09 | Regeneron Pharmaceuticals, Inc. | Anti-FGFR2 antibodies and methods of use thereof |
| EP4273166A4 (en) * | 2020-12-29 | 2025-04-16 | Shenzhen Forward Pharmaceuticals Co., Limited | ANTI-FGFR2 ANTIBODIES AND USE THEREOF |
| US20250277041A1 (en) * | 2021-10-08 | 2025-09-04 | Shenzhen Forward Pharmaceuticals Co., Limited | Anti-fgfr2 adcc enhanced antibody and use thereof |
| TW202342527A (zh) | 2022-02-25 | 2023-11-01 | 美商安進公司 | 鱗狀非小細胞肺癌之治療 |
| CN120418288A (zh) * | 2022-09-30 | 2025-08-01 | 思康睿奇(上海)药业有限公司 | FGFR2b抗体及其用途 |
| CN118852431A (zh) * | 2023-04-28 | 2024-10-29 | 武汉人福创新药物研发中心有限公司 | 抗FGFR2b单抗 |
| CN118994393A (zh) * | 2023-05-19 | 2024-11-22 | 广东东阳光药业股份有限公司 | 一种抗fgfr2抗体及其应用 |
| WO2024255756A1 (zh) * | 2023-06-13 | 2024-12-19 | 南京维立志博生物科技股份有限公司 | 基于共同轻链产生双特异性抗体的方法 |
| WO2025130905A1 (zh) * | 2023-12-18 | 2025-06-26 | 山东先声生物制药有限公司 | 抗FGFR2b抗体-药物缀合物及其应用 |
| WO2025218662A1 (zh) * | 2024-04-16 | 2025-10-23 | 杭州中美华东制药有限公司 | 抗成纤维细胞生长因子受体2b的抗体及其用途 |
| TW202547875A (zh) * | 2024-05-09 | 2025-12-16 | 大陸商正大天晴藥業集團股份有限公司 | 靶向成纖維細胞生長因子受體2IIIb的抗體及其應用 |
| CN121319178A (zh) * | 2024-07-02 | 2026-01-13 | 安博泰克药业有限公司 | 特异性结合FGFR2b的抗体及其与药物的缀合物 |
Family Cites Families (41)
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| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1991000916A2 (en) * | 1989-07-06 | 1991-01-24 | The Regents Of The University Of California | Receptors for fibroblast growth factors |
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| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
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| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
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| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6066718A (en) | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
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| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| WO1997048813A2 (en) | 1996-06-18 | 1997-12-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Fibroblast growth factor receptor activating gene 1 (frag1). fgfr2-frag1 fusions |
| US20030143676A1 (en) * | 1999-03-25 | 2003-07-31 | Genesis Research And Development Corporation Limited | Fibroblast growth factor receptors and methods for their use |
| EP1179541B1 (en) * | 1999-04-28 | 2004-06-16 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting VEGF |
| JP2001302699A (ja) | 2000-04-17 | 2001-10-31 | Nichirei Corp | ヒトｋｇｆｒに対する抗体 |
| US20020115603A1 (en) | 2000-06-22 | 2002-08-22 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
| KR100945108B1 (ko) * | 2001-06-13 | 2010-03-02 | 젠맵 에이/에스 | 표피 성장 인자 수용체 (ｅｇｆｒ)에 대한 인간모노클로날 항체 |
| IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| AU2002368077B2 (en) | 2001-07-12 | 2010-03-04 | Jefferson Foote | Super humanized antibodies |
| ES2363765T3 (es) | 2002-01-31 | 2011-08-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Agonistas de fgfr. |
| KR100493460B1 (ko) * | 2002-08-29 | 2005-06-07 | 재단법인서울대학교산학협력재단 | 암 세포에서 발현되는 ｆｇｆｒ2 이성체 |
| US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
| EA015363B1 (ru) | 2003-07-18 | 2011-06-30 | Эмджен Инк. | Агенты, специфически связывающие фактор роста гепатоцитов, и их применение |
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| DK3290052T3 (da) | 2008-11-07 | 2020-02-03 | Galaxy Biotech Llc | Monoklonale antistoffer mod fibroblastvækstfaktorreceptor 2 |
| WO2011025814A1 (en) | 2009-08-25 | 2011-03-03 | National Jewish Health | Methods and compositions for treatment of lung injury |
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2009
- 2009-11-06 DK DK17191118.3T patent/DK3290052T3/da active
- 2009-11-06 SI SI200932035T patent/SI3290052T1/sl unknown
- 2009-11-06 DK DK14188785.1T patent/DK2842573T3/en active
- 2009-11-06 MX MX2011000455A patent/MX2011000455A/es active IP Right Grant
- 2009-11-06 EP EP09825523.5A patent/EP2365828B1/en active Active
- 2009-11-06 PT PT98255235T patent/PT2365828E/pt unknown
- 2009-11-06 CA CA3287843A patent/CA3287843A1/en active Pending
- 2009-11-06 CN CN200980132269.2A patent/CN102131524B/zh active Active
- 2009-11-06 EP EP17191118.3A patent/EP3290052B1/en active Active
- 2009-11-06 LT LTEP17191118.3T patent/LT3290052T/lt unknown
- 2009-11-06 NO NO14188785A patent/NO2842573T3/no unknown
- 2009-11-06 ES ES14188785.1T patent/ES2646168T3/es active Active
- 2009-11-06 ES ES17191118T patent/ES2770134T3/es active Active
- 2009-11-06 EP EP14188785.1A patent/EP2842573B1/en active Active
- 2009-11-06 US US12/614,282 patent/US8101723B2/en active Active
- 2009-11-06 CA CA2733668A patent/CA2733668C/en active Active
- 2009-11-06 EP EP19193727.5A patent/EP3783024A1/en active Pending
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