NO20100728L - Fremgangsmate for fremstilling av N-monosubstituerte beta-aminoalkoholer - Google Patents
Fremgangsmate for fremstilling av N-monosubstituerte beta-aminoalkoholerInfo
- Publication number
- NO20100728L NO20100728L NO20100728A NO20100728A NO20100728L NO 20100728 L NO20100728 L NO 20100728L NO 20100728 A NO20100728 A NO 20100728A NO 20100728 A NO20100728 A NO 20100728A NO 20100728 L NO20100728 L NO 20100728L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- amino alcohols
- monosubstituted beta
- monosubstituted
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Oppfinnelsen angår en fremgangsmåte for syntetisering av N-monosubstituerte p-aminoalkoholer med formel (I) og/eller et addisjonssalt av en protonsyre, hvor R1 og R2 uavhengig representerer alkyl, cykloalkyl, aryl eller aralkyl, som hver eventuelt er ytterligere substituert med alkyl, alkoksy og/eller halogen, via direkte fremstilling av N-monosubstituerte β-aminoketoner med formel (II) og dens addisjonssalter av protonsyrer, hvor R1 og R2 er som definert ovenfor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02015229 | 2002-07-09 | ||
PCT/EP2003/007411 WO2004005239A1 (en) | 2002-07-09 | 2003-07-09 | PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED β-AMINO ALCOHOLS |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20100728L true NO20100728L (no) | 2005-03-11 |
Family
ID=30011063
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050079A NO329267B1 (no) | 2002-07-09 | 2005-01-06 | Fremgangsmate for fremstilling av N-monosubstituerte beta-aminoalkoholer samt forbindelser |
NO20100728A NO20100728L (no) | 2002-07-09 | 2010-05-19 | Fremgangsmate for fremstilling av N-monosubstituerte beta-aminoalkoholer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050079A NO329267B1 (no) | 2002-07-09 | 2005-01-06 | Fremgangsmate for fremstilling av N-monosubstituerte beta-aminoalkoholer samt forbindelser |
Country Status (20)
Country | Link |
---|---|
US (7) | US20080119661A1 (no) |
JP (1) | JP4546242B2 (no) |
KR (2) | KR101027358B1 (no) |
CN (4) | CN103058986A (no) |
AT (2) | ATE444949T1 (no) |
AU (1) | AU2010201850B2 (no) |
BR (1) | BR0312651B1 (no) |
CA (1) | CA2491472C (no) |
CY (1) | CY1109691T1 (no) |
DE (2) | DE60329640D1 (no) |
DK (1) | DK1539673T3 (no) |
EA (1) | EA009394B1 (no) |
ES (2) | ES2293029T3 (no) |
HK (2) | HK1079765A1 (no) |
IL (1) | IL166107A (no) |
NO (2) | NO329267B1 (no) |
NZ (1) | NZ537567A (no) |
PT (2) | PT1852415E (no) |
SI (1) | SI1852415T1 (no) |
WO (1) | WO2004005239A1 (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2490692A1 (en) | 2002-06-27 | 2004-01-08 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
DE10240026A1 (de) * | 2002-08-27 | 2004-03-11 | Merck Patent Gmbh | Verfahren zur Herstellung von Monoalkylaminoketonen |
DE10302595A1 (de) * | 2003-01-22 | 2004-07-29 | Basf Ag | 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung |
BRPI0506796A (pt) * | 2004-02-19 | 2007-05-22 | Lonza Ag | processo para a preparação de 1-substituìdos-3-aminoálcoois enantiomericamentente puros |
EP1566383A1 (en) * | 2004-02-19 | 2005-08-24 | Lonza AG | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
DE102004021434A1 (de) | 2004-04-30 | 2005-11-24 | Basf Ag | Schnelle schaumarme Netzer für hydrophobe Oberflächen |
EP1868983A1 (en) * | 2005-02-21 | 2007-12-26 | Lonza Ag | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
CZ299270B6 (cs) | 2006-01-04 | 2008-06-04 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
CN101484435A (zh) | 2006-07-03 | 2009-07-15 | 兰贝克赛实验室有限公司 | 制备n-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺及其纯对应异构体盐的方法 |
EP2114912B1 (en) | 2006-12-22 | 2012-04-04 | Synthon B.V. | Process for making duloxetine and related compounds |
WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
US8288141B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
CZ304602B6 (cs) | 2009-09-02 | 2014-07-30 | Zentiva, K. S. | Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu) |
CN108707096B (zh) * | 2018-05-07 | 2021-03-19 | 上海科技大学 | 一种制备氨基醇衍生物的方法 |
CN112961045A (zh) * | 2018-05-30 | 2021-06-15 | 上海科技大学 | 一种降解聚合物的方法 |
CN109134427B (zh) * | 2018-10-24 | 2020-06-30 | 浙江乐普药业股份有限公司 | 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的合成方法 |
CN115677512A (zh) * | 2022-10-27 | 2023-02-03 | 大连万福制药有限公司 | 一种合成乐卡地平中间体n-甲基-3,3-二苯基丙胺盐酸盐的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3031248A1 (de) * | 1980-08-19 | 1982-04-01 | Ruhrchemie Ag, 4200 Oberhausen | Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal |
US5362866A (en) * | 1983-09-02 | 1994-11-08 | Molecular Biosystems, Inc. | Oligonucleotide polymeric support system with an oxidation cleavable link |
CA2042346A1 (en) * | 1990-05-17 | 1991-11-18 | Michael Alexander Staszak | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
US5362886A (en) | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
DE10240026A1 (de) | 2002-08-27 | 2004-03-11 | Merck Patent Gmbh | Verfahren zur Herstellung von Monoalkylaminoketonen |
EP1510517A1 (en) * | 2003-09-01 | 2005-03-02 | Lonza AG | Process for the asymmetric hydrogenation of beta-amino ketones |
-
2003
- 2003-07-09 WO PCT/EP2003/007411 patent/WO2004005239A1/en active IP Right Grant
- 2003-07-09 ES ES03762669T patent/ES2293029T3/es not_active Expired - Lifetime
- 2003-07-09 CN CN2012105072295A patent/CN103058986A/zh active Pending
- 2003-07-09 CA CA2491472A patent/CA2491472C/en not_active Expired - Lifetime
- 2003-07-09 EA EA200500137A patent/EA009394B1/ru not_active IP Right Cessation
- 2003-07-09 CN CNA2006101007056A patent/CN1891683A/zh active Pending
- 2003-07-09 JP JP2004518758A patent/JP4546242B2/ja not_active Expired - Lifetime
- 2003-07-09 KR KR20057000338A patent/KR101027358B1/ko active IP Right Grant
- 2003-07-09 SI SI200331714T patent/SI1852415T1/sl unknown
- 2003-07-09 DE DE60329640T patent/DE60329640D1/de not_active Expired - Lifetime
- 2003-07-09 DE DE2003616698 patent/DE60316698T2/de not_active Expired - Lifetime
- 2003-07-09 NZ NZ537567A patent/NZ537567A/en not_active IP Right Cessation
- 2003-07-09 KR KR1020107027492A patent/KR101021460B1/ko active IP Right Grant
- 2003-07-09 CN CN2009102668505A patent/CN101851168B/zh not_active Expired - Fee Related
- 2003-07-09 AT AT07015051T patent/ATE444949T1/de active
- 2003-07-09 ES ES07015051T patent/ES2334397T3/es not_active Expired - Lifetime
- 2003-07-09 AT AT03762669T patent/ATE374744T1/de active
- 2003-07-09 PT PT07015051T patent/PT1852415E/pt unknown
- 2003-07-09 DK DK03762669T patent/DK1539673T3/da active
- 2003-07-09 PT PT03762669T patent/PT1539673E/pt unknown
- 2003-07-09 CN CNB038162237A patent/CN100497295C/zh not_active Expired - Lifetime
- 2003-07-09 BR BRPI0312651A patent/BR0312651B1/pt not_active IP Right Cessation
-
2005
- 2005-01-03 IL IL166107A patent/IL166107A/en active IP Right Grant
- 2005-01-06 NO NO20050079A patent/NO329267B1/no not_active IP Right Cessation
- 2005-12-22 HK HK05111859A patent/HK1079765A1/xx not_active IP Right Cessation
-
2007
- 2007-12-31 US US12/003,752 patent/US20080119661A1/en not_active Abandoned
-
2009
- 2009-12-30 CY CY091101353T patent/CY1109691T1/el unknown
-
2010
- 2010-05-07 AU AU2010201850A patent/AU2010201850B2/en not_active Ceased
- 2010-05-19 NO NO20100728A patent/NO20100728L/no not_active Application Discontinuation
- 2010-05-28 US US12/801,231 patent/US20100240911A1/en not_active Abandoned
- 2010-08-25 US US12/868,419 patent/US8558014B2/en not_active Expired - Lifetime
-
2011
- 2011-02-10 HK HK11101298A patent/HK1145317A1/xx not_active IP Right Cessation
-
2013
- 2013-07-25 US US13/950,412 patent/US8962865B2/en not_active Expired - Lifetime
-
2014
- 2014-12-23 US US14/580,577 patent/US20150112086A1/en not_active Abandoned
-
2015
- 2015-08-26 US US14/836,357 patent/US20150361064A1/en not_active Abandoned
-
2017
- 2017-09-08 US US15/698,935 patent/US20170369467A1/en not_active Abandoned
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