DK1539673T3 - Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer - Google Patents

Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer

Info

Publication number
DK1539673T3
DK1539673T3 DK03762669T DK03762669T DK1539673T3 DK 1539673 T3 DK1539673 T3 DK 1539673T3 DK 03762669 T DK03762669 T DK 03762669T DK 03762669 T DK03762669 T DK 03762669T DK 1539673 T3 DK1539673 T3 DK 1539673T3
Authority
DK
Denmark
Prior art keywords
preparation
amino alcohols
monosubstituted beta
monosubstituted
beta
Prior art date
Application number
DK03762669T
Other languages
English (en)
Inventor
Dominique Michel
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30011063&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1539673(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK1539673T3 publication Critical patent/DK1539673T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK03762669T 2002-07-09 2003-07-09 Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer DK1539673T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02015229 2002-07-09
PCT/EP2003/007411 WO2004005239A1 (en) 2002-07-09 2003-07-09 PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED β-AMINO ALCOHOLS

Publications (1)

Publication Number Publication Date
DK1539673T3 true DK1539673T3 (da) 2008-01-21

Family

ID=30011063

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03762669T DK1539673T3 (da) 2002-07-09 2003-07-09 Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer

Country Status (20)

Country Link
US (7) US20080119661A1 (da)
JP (1) JP4546242B2 (da)
KR (2) KR101027358B1 (da)
CN (4) CN101851168B (da)
AT (2) ATE444949T1 (da)
AU (1) AU2010201850B2 (da)
BR (1) BR0312651B1 (da)
CA (1) CA2491472C (da)
CY (1) CY1109691T1 (da)
DE (2) DE60329640D1 (da)
DK (1) DK1539673T3 (da)
EA (1) EA009394B1 (da)
ES (2) ES2293029T3 (da)
HK (2) HK1079765A1 (da)
IL (1) IL166107A (da)
NO (2) NO329267B1 (da)
NZ (1) NZ537567A (da)
PT (2) PT1852415E (da)
SI (1) SI1852415T1 (da)
WO (1) WO2004005239A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60328496D1 (en) 2002-06-27 2009-09-03 Health Research Inc Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie
DE10240026A1 (de) * 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
DE10302595A1 (de) 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
DK1720852T3 (da) * 2004-02-19 2012-10-22 Lonza Ag Fremgangsmåde til fremstilling af enantiomerrene 1-substituerede 3-aminoalkoholer
DE102004021434A1 (de) 2004-04-30 2005-11-24 Basf Ag Schnelle schaumarme Netzer für hydrophobe Oberflächen
KR20070104942A (ko) 2005-02-21 2007-10-29 론자 아게 거울상적으로 순수한 1-치환-3-아미노알코올의 제조 방법
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
CA2656128A1 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3(1-naphthaleneoxy)-3-(2-thienyl)propanamine
ATE552250T1 (de) 2006-12-22 2012-04-15 Synthon Bv Verfahren zur herstellung von duloxetin und verwandten verbindungen
WO2010025238A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
CN108707096B (zh) * 2018-05-07 2021-03-19 上海科技大学 一种制备氨基醇衍生物的方法
CN108947798B (zh) * 2018-05-30 2021-03-02 上海科技大学 一种降解聚合物的方法
CN109134427B (zh) * 2018-10-24 2020-06-30 浙江乐普药业股份有限公司 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的合成方法
CN115677512A (zh) * 2022-10-27 2023-02-03 大连万福制药有限公司 一种合成乐卡地平中间体n-甲基-3，3-二苯基丙胺盐酸盐的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3031248A1 (de) * 1980-08-19 1982-04-01 Ruhrchemie Ag, 4200 Oberhausen Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal
US5362866A (en) * 1983-09-02 1994-11-08 Molecular Biosystems, Inc. Oligonucleotide polymeric support system with an oxidation cleavable link
IL98108A0 (en) * 1990-05-17 1992-06-21 Lilly Co Eli Chiral synthesis of 1-aryl-3-aminopropan-1-ols
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
DE10240026A1 (de) 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
EP1510517A1 (en) * 2003-09-01 2005-03-02 Lonza AG Process for the asymmetric hydrogenation of beta-amino ketones

Also Published As

Publication number Publication date
CN1665773A (zh) 2005-09-07
HK1079765A1 (en) 2006-04-13
CN1891683A (zh) 2007-01-10
JP4546242B2 (ja) 2010-09-15
IL166107A0 (en) 2006-01-15
SI1852415T1 (sl) 2010-01-29
US20150361064A1 (en) 2015-12-17
NO20050079L (no) 2005-03-11
KR101027358B1 (ko) 2011-04-11
DE60316698D1 (de) 2007-11-15
WO2004005239A1 (en) 2004-01-15
CN101851168B (zh) 2013-07-03
CA2491472A1 (en) 2004-01-15
BR0312651B1 (pt) 2017-10-31
CN103058986A (zh) 2013-04-24
KR101021460B1 (ko) 2011-03-16
AU2003250924A1 (en) 2004-01-23
KR20100135331A (ko) 2010-12-24
EA200500137A1 (ru) 2005-08-25
CY1109691T1 (el) 2014-08-13
US8558014B2 (en) 2013-10-15
CN100497295C (zh) 2009-06-10
US20130310574A1 (en) 2013-11-21
CA2491472C (en) 2011-09-27
ES2293029T3 (es) 2008-03-16
US20150112086A1 (en) 2015-04-23
ATE374744T1 (de) 2007-10-15
ES2334397T3 (es) 2010-03-09
EA009394B1 (ru) 2007-12-28
ATE444949T1 (de) 2009-10-15
DE60316698T2 (de) 2008-07-17
NZ537567A (en) 2006-11-30
DE60329640D1 (de) 2009-11-19
JP2005532383A (ja) 2005-10-27
AU2010201850B2 (en) 2011-08-25
IL166107A (en) 2012-06-28
PT1852415E (pt) 2009-12-18
US20110004007A1 (en) 2011-01-06
CN101851168A (zh) 2010-10-06
AU2010201850A1 (en) 2010-05-27
US20100240911A1 (en) 2010-09-23
US20080119661A1 (en) 2008-05-22
PT1539673E (pt) 2007-11-14
KR20050017092A (ko) 2005-02-21
US8962865B2 (en) 2015-02-24
NO20100728L (no) 2005-03-11
BR0312651A (pt) 2005-04-26
HK1145317A1 (en) 2011-04-15
US20170369467A1 (en) 2017-12-28
NO329267B1 (no) 2010-09-20

Similar Documents

Publication Publication Date Title
NO20100728L (no) Fremgangsmate for fremstilling av N-monosubstituerte beta-aminoalkoholer
ATE464307T1 (de) Mif-hemmer
BRPI0518229A (pt) composto de benzeno tendo 2 ou mais substituintes
ATE544760T1 (de) Heterocyclische hydrazidverbindung und ihre verwendung als pestizid
EA200601457A1 (ru) Ингибиторы вирусной полимеразы
TW200736195A (en) Methods for preparing sulfonamide substituted alcohols and intermediates thereof
DE602005011780D1 (de) Triazinderivate mit carbamatfunktion
MXPA05008878A (es) Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso.
TW200732295A (en) Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
EA200970943A1 (ru) Новое пиримидиновое соединение, имеющее структуру дибензиламина, и лекарственное средство, включающее данное соединение
AR060912A1 (es) Benzamidinas insecticidas
TW200738145A (en) Pesticidal mixtures
EA200700766A1 (ru) Способ получения производных [1,4,5]-оксадиазепина
TW200621685A (en) Hydroxynaphthoic acid hydrazide compound and method for preparing the same
EA200400724A1 (ru) Метаболиты (3-{[(4-трет-бутилбензил)-(пиридин-3-сульфонил)амино]метил}фенокси)уксусной кислоты
ATE517623T1 (de) Verwendung von methylphenidat-derivaten
DOP2006000133A (es) Derivados de 4,5 diarilpiroxol, su preparación y su aplicación en terapeútica
DE602006014001D1 (de) Herstellung von 2-aminothiazol-5-carbonsäurederivaten
TW200735779A (en) Pesticidal mixtures
CO4970700A1 (es) Proceso para la preparacion de pirimidinas sustituidas
MXPA05009725A (es) Derivados de ftalamida insecticidas.
NZ543648A (en) Novel stabilising system for halogenous polymers comprising a perfluoroalkanesulphonate salt and an alkanolamine
ATE294214T1 (de) Stabilisatorzusammensetzung ii
ATE489368T1 (de) Pyrimidinonverbindungen als calcilytica
ATE299932T1 (de) Verfahren der zellkultivierung