NO20084792L - Substituerte imidazol-4-karboksamider som kolecystokinin-1-reseptormodulatorer - Google Patents

Substituerte imidazol-4-karboksamider som kolecystokinin-1-reseptormodulatorer

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Publication number
NO20084792L
NO20084792L NO20084792A NO20084792A NO20084792L NO 20084792 L NO20084792 L NO 20084792L NO 20084792 A NO20084792 A NO 20084792A NO 20084792 A NO20084792 A NO 20084792A NO 20084792 L NO20084792 L NO 20084792L
Authority
NO
Norway
Prior art keywords
carboxamides
cholecystokinin
substituted imidazole
receptor modulators
receptor
Prior art date
Application number
NO20084792A
Other languages
English (en)
Inventor
Richard Berger
Scott Edmondson
Alexa Hansen
Cheng Zhu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20084792L publication Critical patent/NO20084792L/no

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
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  • Gastroenterology & Hepatology (AREA)
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Abstract

Visse nye substituerte imidazol-4-karboksamider er ligander for humankolecystokininreseptoren, og er særlig selektive ligander for humankolecystokinin-l-reseptoren (CCK-1R). De er derfor anvendbare til behandling, kontroll eller forebyggelse av sykdommer og forstyrrelser som gir respons på moduleringen av CCK-1R, slik som sykelig fedme og sukkersyke.
NO20084792A 2006-04-14 2008-11-13 Substituerte imidazol-4-karboksamider som kolecystokinin-1-reseptormodulatorer NO20084792L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79196106P 2006-04-14 2006-04-14
PCT/US2007/008832 WO2007120655A2 (en) 2006-04-14 2007-04-10 Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators

Publications (1)

Publication Number Publication Date
NO20084792L true NO20084792L (no) 2009-01-13

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ID=38606634

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NO20084792A NO20084792L (no) 2006-04-14 2008-11-13 Substituerte imidazol-4-karboksamider som kolecystokinin-1-reseptormodulatorer

Country Status (16)

Country Link
US (2) US7795265B2 (no)
EP (1) EP2010519B1 (no)
JP (1) JP5155999B2 (no)
KR (1) KR20080110809A (no)
CN (1) CN101466698A (no)
AT (1) ATE515504T1 (no)
AU (1) AU2007238771B2 (no)
BR (1) BRPI0709972A2 (no)
CA (1) CA2649403C (no)
IL (1) IL194237A0 (no)
MX (1) MX2008013237A (no)
NO (1) NO20084792L (no)
NZ (1) NZ571412A (no)
RU (1) RU2008144962A (no)
WO (1) WO2007120655A2 (no)
ZA (1) ZA200807986B (no)

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JP2009533445A (ja) 2006-04-14 2009-09-17 メルク エンド カムパニー インコーポレーテッド コレシストキニン−１受容体モジュレータとしての置換イミダゾール４−カルボキサミド
BRPI0709972A2 (pt) * 2006-04-14 2011-08-02 Merck & Co Inc composto, composição farmacêutica, e, uso de um composto
US7759352B2 (en) 2006-04-14 2010-07-20 Merck Sharp & Dohme Corp. Substituted imidazole-4-carboxamides as cholecystokinin-1 receptor modulators
WO2010067233A1 (en) 2008-12-08 2010-06-17 Pfizer Inc. 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir)
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
TWI523857B (zh) * 2011-08-05 2016-03-01 Teijin Ltd Synthesis of Polycyclic Aromatic Compounds, Aromatic Polymers, and Aromatic Compounds
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
TWI827583B (zh) 2018-03-08 2024-01-01 美商英塞特公司 作為ＰＩ３Ｋ-γ抑制劑之胺基吡嗪二醇化合物
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
CA3156985A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
CN115667277A (zh) 2020-02-28 2023-01-31 卡尔优普公司 Gpr40激动剂
CN116332807A (zh) * 2023-03-24 2023-06-27 安徽秀朗新材料科技有限公司 一种3-（三氟甲基磺酰基）-2-萘甲酸甲酯的生产工艺

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BRPI0709972A2 (pt) * 2006-04-14 2011-08-02 Merck & Co Inc composto, composição farmacêutica, e, uso de um composto
US7759352B2 (en) 2006-04-14 2010-07-20 Merck Sharp & Dohme Corp. Substituted imidazole-4-carboxamides as cholecystokinin-1 receptor modulators
JP2009533445A (ja) 2006-04-14 2009-09-17 メルク エンド カムパニー インコーポレーテッド コレシストキニン−１受容体モジュレータとしての置換イミダゾール４−カルボキサミド

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US7795265B2 (en) 2010-09-14
NZ571412A (en) 2010-07-30
MX2008013237A (es) 2009-03-06
KR20080110809A (ko) 2008-12-19
ZA200807986B (en) 2009-10-28
CA2649403C (en) 2011-06-21
IL194237A0 (en) 2009-09-22
AU2007238771A1 (en) 2007-10-25
JP5155999B2 (ja) 2013-03-06
US20090118300A1 (en) 2009-05-07
ATE515504T1 (de) 2011-07-15
US20100311649A1 (en) 2010-12-09
CN101466698A (zh) 2009-06-24
RU2008144962A (ru) 2010-05-20
BRPI0709972A2 (pt) 2011-08-02
AU2007238771B2 (en) 2011-11-24
CA2649403A1 (en) 2007-10-25
JP2009533444A (ja) 2009-09-17
US7977339B2 (en) 2011-07-12
WO2007120655A3 (en) 2008-09-25
WO2007120655A2 (en) 2007-10-25
EP2010519A2 (en) 2009-01-07
EP2010519B1 (en) 2011-07-06

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