NO20082507L - Fremgangsmate for fremstilling av beta-(fluorfenyl)-propanoatesterderivater - Google Patents

Fremgangsmate for fremstilling av beta-(fluorfenyl)-propanoatesterderivater

Info

Publication number
NO20082507L
NO20082507L NO20082507A NO20082507A NO20082507L NO 20082507 L NO20082507 L NO 20082507L NO 20082507 A NO20082507 A NO 20082507A NO 20082507 A NO20082507 A NO 20082507A NO 20082507 L NO20082507 L NO 20082507L
Authority
NO
Norway
Prior art keywords
preparation
formula
fluorophenyl
beta
ester derivatives
Prior art date
Application number
NO20082507A
Other languages
English (en)
Inventor
John Oldfield
Ian Patel
Andrew Williams
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20082507L publication Critical patent/NO20082507L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/54—Acrylic acid esters; Methacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

En fremgangsmåte for fremstilling av en forbindelse med formel (I): som omfatter å reagere en forbindelse med formel (II): Med en fluorinert bortype med formel (III): i nærvær av: en alkohol; en rodium (I) prekatalysatortype; et egnet ligand som binder seg til et rodium (I) prekatalysatortypen for å danne et katalysatorkompleks; en base; og et egnet løsningsmiddel; der fremgangsmåten utføres ved en temperatur i området 40 til 110°C. Forbindelsene med formel (I) er nyttige ved fremstillingen av farmasøytisk aktive forbindelser.
NO20082507A 2005-11-16 2008-06-03 Fremgangsmate for fremstilling av beta-(fluorfenyl)-propanoatesterderivater NO20082507L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0502515 2005-11-16
PCT/GB2006/004205 WO2007057643A1 (en) 2005-11-16 2006-11-13 Process for preparing beta- (fluorophenyl) -propanoate ester derivatives

Publications (1)

Publication Number Publication Date
NO20082507L true NO20082507L (no) 2008-06-03

Family

ID=37734255

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082507A NO20082507L (no) 2005-11-16 2008-06-03 Fremgangsmate for fremstilling av beta-(fluorfenyl)-propanoatesterderivater

Country Status (14)

Country Link
US (1) US20090111993A1 (no)
EP (1) EP1951652A1 (no)
JP (1) JP2009515937A (no)
KR (1) KR20080067661A (no)
CN (1) CN101309891A (no)
AR (1) AR057605A1 (no)
AU (1) AU2006314271A1 (no)
BR (1) BRPI0618617A2 (no)
CA (1) CA2627552A1 (no)
IL (1) IL191056A0 (no)
NO (1) NO20082507L (no)
TW (1) TW200804269A (no)
WO (1) WO2007057643A1 (no)
ZA (1) ZA200803943B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2447245A1 (en) * 2010-10-28 2012-05-02 Cognis IP Management GmbH A method to prepare beta-functionalized aliphatic esters
RU2020121714A (ru) 2017-12-01 2022-01-04 Байер Фарма Акциенгезельшафт Способ получения (3s)-3-(4-хлор-3-{ [(2s,3r)-2-(4-хлорфенил)-4,4,4-трифтор-3-метилбутаноил]амино} фенил)-3-циклопропилпропановой кислоты и её кристаллической формы для применения в качестве фармацевтического активного вещества
CN111138350B (zh) * 2020-01-03 2021-08-10 中国药科大学 一种右氯苯那敏和右溴苯那敏的不对称合成方法
CN111517954A (zh) * 2020-06-08 2020-08-11 浙江师范大学 一种（z)-5-氟-2-二氟亚甲基烯烃衍生物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0403106D0 (sv) * 2004-12-20 2004-12-20 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
IL191056A0 (en) 2008-12-29
US20090111993A1 (en) 2009-04-30
KR20080067661A (ko) 2008-07-21
CA2627552A1 (en) 2007-05-24
BRPI0618617A2 (pt) 2011-09-06
JP2009515937A (ja) 2009-04-16
AU2006314271A1 (en) 2007-05-24
EP1951652A1 (en) 2008-08-06
ZA200803943B (en) 2009-03-25
TW200804269A (en) 2008-01-16
CN101309891A (zh) 2008-11-19
AR057605A1 (es) 2007-12-05
WO2007057643A1 (en) 2007-05-24

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