AR057605A1 - Proceso quimico - Google Patents

Proceso quimico

Info

Publication number
AR057605A1
AR057605A1 ARP060105034A ARP060105034A AR057605A1 AR 057605 A1 AR057605 A1 AR 057605A1 AR P060105034 A ARP060105034 A AR P060105034A AR P060105034 A ARP060105034 A AR P060105034A AR 057605 A1 AR057605 A1 AR 057605A1
Authority
AR
Argentina
Prior art keywords
formula
species
rhodium
compounds
compound
Prior art date
Application number
ARP060105034A
Other languages
English (en)
Inventor
Andrew Williams
John Oldfield
Ian Patel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR057605A1 publication Critical patent/AR057605A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/54—Acrylic acid esters; Methacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un proceso para preparar un compuesto de formula (1), que comprende hacer reaccionar un compuesto de formula (2), con una especie de boro fluorada de formula (3), en presencia de: un alcohol, una especie pre-catalizadora de rodio (I), un ligando adecuado que se une a la especie pre-catalizadora de rodio (I) para formar un complejo catalizador, una base, y un solvente adecuado; donde el proceso se lleva a cabo a una temperatura en el rango de entre 40 y 110sC. Los compuestos de formula (1) son utiles en el preparacion de compuestos con actividad farmacéutica.
ARP060105034A 2005-11-16 2006-11-16 Proceso quimico AR057605A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0502515 2005-11-16

Publications (1)

Publication Number Publication Date
AR057605A1 true AR057605A1 (es) 2007-12-05

Family

ID=37734255

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105034A AR057605A1 (es) 2005-11-16 2006-11-16 Proceso quimico

Country Status (14)

Country Link
US (1) US20090111993A1 (es)
EP (1) EP1951652A1 (es)
JP (1) JP2009515937A (es)
KR (1) KR20080067661A (es)
CN (1) CN101309891A (es)
AR (1) AR057605A1 (es)
AU (1) AU2006314271A1 (es)
BR (1) BRPI0618617A2 (es)
CA (1) CA2627552A1 (es)
IL (1) IL191056A0 (es)
NO (1) NO20082507L (es)
TW (1) TW200804269A (es)
WO (1) WO2007057643A1 (es)
ZA (1) ZA200803943B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2447245A1 (en) * 2010-10-28 2012-05-02 Cognis IP Management GmbH A method to prepare beta-functionalized aliphatic esters
SG11202004577VA (en) 2017-12-01 2020-06-29 Bayer Pharma AG Method for producing (3s)-3-(4-chlor-3-{[(2s,3r)-2-(4-chlorphenyl)-4,4,4-trifluor-3-methylbutanoyl]amino}phenyl)-3-cyclo-propylpropanoic acid and the crystalline form thereof for use as a pharmaceutical ingredient
CN111138350B (zh) * 2020-01-03 2021-08-10 中国药科大学 一种右氯苯那敏和右溴苯那敏的不对称合成方法
CN111517954A (zh) * 2020-06-08 2020-08-11 浙江师范大学 一种（z)-5-氟-2-二氟亚甲基烯烃衍生物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0403106D0 (sv) * 2004-12-20 2004-12-20 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
US20090111993A1 (en) 2009-04-30
BRPI0618617A2 (pt) 2011-09-06
IL191056A0 (en) 2008-12-29
TW200804269A (en) 2008-01-16
NO20082507L (no) 2008-06-03
ZA200803943B (en) 2009-03-25
EP1951652A1 (en) 2008-08-06
WO2007057643A1 (en) 2007-05-24
KR20080067661A (ko) 2008-07-21
AU2006314271A1 (en) 2007-05-24
CN101309891A (zh) 2008-11-19
JP2009515937A (ja) 2009-04-16
CA2627552A1 (en) 2007-05-24

Similar Documents

Publication Publication Date Title
Corberán et al. Coinage metal complexes with N-heterocyclic carbene ligands as selective catalysts in diboration reaction
PE20091582A1 (es) Procedimiento para la preparacion de dihidropteridinonas
Byers et al. The oxidative addition of lodomethane to [PdMe 2 (bpy)] and the X-ray structure of the organopalladium (IV) product fac-[PdMe 3 (bpy) l](bpy= 2, 2′-bipyridyl)
BRPI0509587A (pt) processo em grande escala para preparar um composto de éster borÈnico, aminoborÈnico e composição que compreende um solvente de éter
AR092987A1 (es) Mezclas de bifosfitos isomericos constitucionales utilizadas en una composicion catalitica para la reaccion de hidroformilacion
AR022701A1 (es) Proceso para preparar eteratos de trifluoroarilaluminio
AR057605A1 (es) Proceso quimico
AR050518A1 (es) Proceso de amonolisis para la preparacion de intermedarios para inhibidores de dpp iv
PE20080109A1 (es) N-sulfonilacion selectiva de alcoholes sustituidos con 2-aminotrifluoralquilo
BRPI0507900A (pt) métodos de preparo de um catalisador de oligomerização de olefina
HRP20120031T1 (hr) Postupak kemijskog spajanja sa derivatom fenil boronske kiseline
Halli et al. Synthesis of N‐Acyl‐N, O‐acetals from Aldehydes, Amides and Alcohols
AR036637A1 (es) Fosfonitas, quelatos de fosfonitas, procedimiento para su obtencion, el uso de las mismas como ligandos en complejos de metal de transicion, la utilizacion de los complejos como catalizadores y los procedimientos en presencia de tales complejos de metal transitorio como catalizadores
Wong et al. Stereocontrolled synthesis of arylomycin-based gram-negative antibiotic GDC-5338
ITMI20050550A1 (it) Procedimento per la preparazione di adapalene
Ping et al. Rhodium (III)-catalyzed ortho-C–H alkylation of 2-arylbenzothiazoles and 2-arylthiazoles with potassium alkyltrifluoroborates
CN103464207B (zh) 一种稀土配合物催化剂,其制备方法、用途以及应用方法
PE20061068A1 (es) Procedimiento para la preparacion de compuestos benzoxazol substituidos
AR053864A1 (es) Proceso para la fabricacion a gran escala de indoxacarb y 1,2,4 oxadiazinas asociadas
EA200801332A1 (ru) Способ получения карбоксанилидов
AR044329A1 (es) Proceso de sintesis de modafinil
Liu et al. Zinc-mediated radical reactions of per-(or poly) fluorophenyl aromatic aldimines in aqueous media
ECSP014080A (es) Un compuesto para preparar compuestos de bifenilo
AR042194A1 (es) Metodo para preparar inhibidores de fosfodiesterasa - 4
AR060341A1 (es) Procedimiento para producir 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propionaldehido y cis-4-{3-[4-(1,1dimetil-propil)-fenil]-2-metil-propil}-2,6-dimetil-morfolina (amorolfina)

Legal Events

Date Code Title Description
FB Suspension of granting procedure