NO20081084L - Arylpyridiner og fremgangsmater for deres anvendelse - Google Patents

Arylpyridiner og fremgangsmater for deres anvendelse

Info

Publication number
NO20081084L
NO20081084L NO20081084A NO20081084A NO20081084L NO 20081084 L NO20081084 L NO 20081084L NO 20081084 A NO20081084 A NO 20081084A NO 20081084 A NO20081084 A NO 20081084A NO 20081084 L NO20081084 L NO 20081084L
Authority
NO
Norway
Prior art keywords
methods
aryl pyridines
pyridines
aryl
disorders
Prior art date
Application number
NO20081084A
Other languages
English (en)
Inventor
David J Augeri
James E Tarver
Qinghong Fu
Michael Victor Voronkov
Doan Hackley
Michael E Mertzman
Marianne Carlsen
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of NO20081084L publication Critical patent/NO20081084L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Arylpyridiner, preparater inneholdende disse og fremgangsmåter for deres bruk for å behandle, forhindre og holde i sjakk en rekke forskjellige sykdommer og forstyrrelser.
NO20081084A 2005-08-02 2008-02-29 Arylpyridiner og fremgangsmater for deres anvendelse NO20081084L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70474205P 2005-08-02 2005-08-02
PCT/US2006/030269 WO2007016674A2 (en) 2005-08-02 2006-07-31 2-aminoaryl pyridines as protein kinases inhibitors

Publications (1)

Publication Number Publication Date
NO20081084L true NO20081084L (no) 2008-02-29

Family

ID=37517029

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081084A NO20081084L (no) 2005-08-02 2008-02-29 Arylpyridiner og fremgangsmater for deres anvendelse

Country Status (11)

Country Link
US (1) US8153804B2 (no)
EP (1) EP1919895A2 (no)
JP (1) JP2009503103A (no)
KR (1) KR20080040692A (no)
CN (1) CN101258142A (no)
AU (1) AU2006275403A1 (no)
BR (1) BRPI0614262A2 (no)
CA (1) CA2617413A1 (no)
MX (1) MX2008001538A (no)
NO (1) NO20081084L (no)
WO (1) WO2007016674A2 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3354650T1 (sl) 2008-12-19 2022-06-30 Vertex Pharmaceuticals Incorporated Spojine, uporabne kot zaviralci ATR kinaze
RU2012153675A (ru) 2010-05-12 2014-06-20 Вертекс Фармасьютикалз Инкорпорейтед Соединения, пригодные в качестве ингибиторов atr киназы
CN102947272A (zh) * 2010-05-12 2013-02-27 沃泰克斯药物股份有限公司 用作atr激酶抑制剂的2-氨基吡啶衍生物
EP2569287B1 (en) 2010-05-12 2014-07-09 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
JP5997709B2 (ja) * 2011-03-04 2016-09-28 レクシコン ファーマシューティカルズ インコーポレイテッド Ｍｓｔ１キナーゼ阻害剤及びその使用方法
IN2014KN00929A (no) 2011-09-30 2015-08-21 Vertex Pharma
CN108685922A (zh) 2011-09-30 2018-10-23 沃泰克斯药物股份有限公司 用atr抑制剂治疗胰腺癌和非小细胞肺癌
PL2833973T3 (pl) 2012-04-05 2018-02-28 Vertex Pharmaceuticals Incorporated Związki użyteczne jako inhibitory kinazy ATR i ich terapie skojarzone
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
WO2016161145A1 (en) * 2015-03-31 2016-10-06 Dana-Farber Cancer Institute, Inc. Stk4 inhibitors for treatment of hematologic malignancies
EP3355926A4 (en) 2015-09-30 2019-08-21 Vertex Pharmaceuticals Inc. METHOD FOR THE TREATMENT OF CANCER WITH A COMBINATION OF DNA DAMAGING AGENTS AND ATR INHIBITORS
EP3728230A1 (en) 2017-12-22 2020-10-28 Ravenna Pharmaceuticals, Inc. Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors
ES2910071T3 (es) 2018-03-08 2022-05-11 Incyte Corp Compuestos de aminopirazina diol como inhibidores de PI3K-Y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
US11396502B2 (en) 2018-11-13 2022-07-26 Incyte Corporation Substituted heterocyclic derivatives as PI3K inhibitors
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
WO2020102198A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412798A3 (en) * 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
US6069766A (en) * 1990-02-09 2000-05-30 Seagate Technology, Inc. Miniature hard disc drive having low profile actuator arm voice coil and spindle motors
JPH0558997A (ja) 1991-09-04 1993-03-09 Mitsubishi Kasei Corp チオカルバモイルアセトニトリル誘導体
SE9401353D0 (sv) 1994-04-21 1994-04-21 Pharmacia Ab Novel antitumour compounds with antimitotic activity
GB9525296D0 (en) 1995-12-11 1996-02-07 Merck Sharp & Dohme Therapeutic agents
ATE227708T1 (de) 1996-07-10 2002-11-15 Schering Corp 1,4-disubstituierte piperdine als muskarin- antagonisten
US5952349A (en) * 1996-07-10 1999-09-14 Schering Corporation Muscarinic antagonists for treating memory loss
WO1998006691A2 (en) 1996-08-14 1998-02-19 Warner-Lambert Company Low molecular weight dendritic compounds as pharmaceutical agents
AR009811A1 (es) * 1996-09-26 2000-05-03 Novartis Ag Compuestos herbicidas, proceso para su produccion, proceso para la produccion de intermediarios, compuestos intermediarios para su exclusivo usoen dicho proceso, composicion que tiene actividad herbicida selectiva y proceso para el control selectivo de malas hierbas y gramineas en cultivos de planta
DE19651099A1 (de) 1996-12-09 1998-06-10 Consortium Elektrochem Ind Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
WO1999055675A1 (de) * 1998-04-29 1999-11-04 Axiva Gmbh Verfahren zur katalytischen herstellung von substituierten bipyridylderivaten
JP4570057B2 (ja) 1999-09-09 2010-10-27 三菱レイヨン株式会社 アリールピリジン誘導体の製造法
US6458789B1 (en) * 1999-09-29 2002-10-01 Lion Bioscience Ag 2-aminopyridine derivatives and combinatorial libraries thereof
US6949571B2 (en) * 2000-06-12 2005-09-27 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
ATE277938T1 (de) * 2000-07-18 2004-10-15 Leo Pharma As Matrix metalloproteinase inhibitoren
JP2002193938A (ja) * 2000-12-01 2002-07-10 Bayer Ag ４−アリールピリジン誘導体
CA2450262A1 (en) * 2001-06-12 2002-12-19 Neurogen Corporation 2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines as crf1 receptor modulators
US20030082191A1 (en) * 2001-08-29 2003-05-01 Poduslo Joseph F. Treatment for central nervous system disorders
US7304061B2 (en) * 2002-04-26 2007-12-04 Vertex Pharmaceuticals Incorporated Heterocyclic inhibitors of ERK2 and uses thereof
US20040082627A1 (en) * 2002-06-21 2004-04-29 Darrow James W. Certain aromatic monocycles as kinase modulators
US7015227B2 (en) * 2002-06-21 2006-03-21 Cgi Pharmaceuticals, Inc. Certain amino-substituted monocycles as kinase modulators
AU2003213397B2 (en) 2002-07-05 2008-12-04 Japan Tobacco Inc. Sterility recovery genes to rice BT type male sterile cytoplasm
JP4570955B2 (ja) * 2002-07-09 2010-10-27 バーテクス ファーマスーティカルズ インコーポレイテッド プロテインキナーゼ阻害活性を持つイミダゾール類
JP2004107271A (ja) 2002-07-22 2004-04-08 Mitsubishi Rayon Co Ltd 水溶性アルキルホスフィン誘導体とその製造方法、ホスフィン配位子錯体並びにビアリール誘導体の製造方法
EP1575919A1 (en) 2002-11-11 2005-09-21 Bayer HealthCare AG Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist
JP2004182713A (ja) 2002-12-03 2004-07-02 Api Corporation ハロアリール置換ピリジン誘導体の製造方法
US20040142978A1 (en) 2002-12-12 2004-07-22 Pharmacia Corporation Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
AU2003297160A1 (en) * 2002-12-18 2004-07-22 Vertex Pharmaceuticals Incorporated Benzisoxazole derivatives useful as inhibitors of protein kinases
DE10315573A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
AU2004233835B2 (en) 2003-04-24 2010-02-25 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1622616B1 (en) 2003-04-24 2011-06-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
JP2004359642A (ja) 2003-06-06 2004-12-24 Nippon Shokubai Co Ltd マレイミド化合物およびその製造方法

Also Published As

Publication number Publication date
WO2007016674A2 (en) 2007-02-08
MX2008001538A (es) 2008-04-04
CN101258142A (zh) 2008-09-03
JP2009503103A (ja) 2009-01-29
WO2007016674A3 (en) 2007-03-15
EP1919895A2 (en) 2008-05-14
US8153804B2 (en) 2012-04-10
KR20080040692A (ko) 2008-05-08
US20070032501A1 (en) 2007-02-08
CA2617413A1 (en) 2007-02-08
BRPI0614262A2 (pt) 2011-03-15
AU2006275403A1 (en) 2007-02-08

Similar Documents

Publication Publication Date Title
NO20081084L (no) Arylpyridiner og fremgangsmater for deres anvendelse
NL301145I2 (nl) Tirbanibulin
NO20083324L (no) Multisykliske aminosyrederivater og anvendelse derav
NO20070908L (no) Sammensmeltede ringheterocykelkinasemodulatorer
NO20092612L (no) Forbindelser og metode for kinasemodulering og indikasjoner for dette
NO20083002L (no) Fremgangsmate for anvendelse av CD40-bindende forbindelser
MX2009012623A (es) Moduladores de cinasa heterociclicos.
NO20073628L (no) Pyridoner som er nyttige som inhibitorer av kinaser
TNSN07027A1 (en) Pyrrolo-pyridine kinase modulators
EA201170492A1 (ru) Векторы для генной терапии и цитозиндезаминазы
DK1543011T3 (da) Thienopyrrolyl- og furanopyrrolylforbindelser og deres anvendelse som histamin H4-receptorligander
NO20085373L (no) P38 inhibitorer, deres fremstilling og anvendelse
ATE517896T1 (de) P38-kinase-inhibitoren
ATE416177T1 (de) Hetaryloxy-substituierte phenylaminopyrimidine als rho-kinasehemmer
NO20082753L (no) Transdermalt terapeutisk system
EA200802213A1 (ru) Способы лечения заболеваний крови
TW200745109A (en) Pyrrolo-pyridine kinase modulators
NO20054371L (no) Somatostatin-dopamin kimaere analoger
NO20073033L (no) Cytotoksiske midler innbefattende nye taksaner
EA200700717A1 (ru) Сульфонамиды
NO20052028L (no) Pyridinderivater som CB2 reseptor modulatorer
NO20081013L (no) 7-substituerte aza-indazoler, sammensetninger inneholdende disse, produksjonsmetode og anvendelse derav
NO20064976L (no) Azanidoler som er nyttige som inhibitorer av rock og andre proteinkinaser
EA200970402A1 (ru) Триазолопиридазиновые модуляторы протеинкиназ
EA200800835A1 (ru) Циклопропиламины в качестве модуляторов рецептора гистамина н

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application