NO20080025L - Pyrazolderivater som CB1 modulatorer - Google Patents
Pyrazolderivater som CB1 modulatorerInfo
- Publication number
- NO20080025L NO20080025L NO20080025A NO20080025A NO20080025L NO 20080025 L NO20080025 L NO 20080025L NO 20080025 A NO20080025 A NO 20080025A NO 20080025 A NO20080025 A NO 20080025A NO 20080025 L NO20080025 L NO 20080025L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl group
- hydroxy
- substituted
- group
- cyano
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Foreliggende oppfinnelse angår forbindelser med formel I hvor R1 representerer en gruppe R5O- hvor R5 representerer en C3-7alkylgruppe substituert med én eller flere fluor eller R5 representerer en C3-7alkylsulfonylgruppe som eventuelt er substituert med én eller flere fluor; R2 representerer en C1-4alkylgruppe, hydroksy, fluor, klor eller cyano hvor hver R2 er uavhengig valgt når n er >1; R3 representerer a) cykloheksyl eventuelt substituert med én eller flere av de følgende: hydroksy, fluor, amino, mono eller diC1-3alkylamino, karboksy eller en C1-4alkoksykarbonylgruppe b) piperidino substituert med én eller flere hydroksy c) usubstituert piperidino men bare når én av de følgende gjelder: R4 representerer cyano eller R1 representerer 3-fluorpropylsulfonyloksy eller R1 representerer 3,3,3-trifluorpropoksy eller R1 representerer 3-fluorpropoksy eller R2 er metyl d) fenyl substituert med én eller flere av de følgende: hydroksy, halogen eller en C1-4alkylgruppe e) pyridyl substituert med en C1-4alkylgruppe eller f) en C4-9alkylgruppe; R4 representerer cyano eller metyl; og n er 1, 2 eller 3 og farmasøytisk akseptable salter derav og fremgangsmåter for fremstilling av slike forbindelser, anvendelse av dem ved behandling av fedme, psykiatrisk og nevrologiske lidelser, metoder for deres terapeutiske anvendelse og farmasøytiske preparater inneholdende dem. 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0514738.4A GB0514738D0 (en) | 2005-07-19 | 2005-07-19 | Therapeutic agents |
PCT/GB2006/002631 WO2007010217A1 (en) | 2005-07-19 | 2006-07-17 | PYRAZOLE DERIVATIVES AS CBl MODULATORS |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20080025L true NO20080025L (no) | 2008-04-16 |
Family
ID=34897416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20080025A NO20080025L (no) | 2005-07-19 | 2008-01-03 | Pyrazolderivater som CB1 modulatorer |
Country Status (16)
Country | Link |
---|---|
US (1) | US20080287517A1 (no) |
EP (1) | EP1910331A1 (no) |
JP (1) | JP2009501771A (no) |
KR (1) | KR20080032206A (no) |
CN (1) | CN101223159A (no) |
AR (1) | AR057461A1 (no) |
AU (1) | AU2006271499A1 (no) |
CA (1) | CA2615588A1 (no) |
GB (1) | GB0514738D0 (no) |
IL (1) | IL188388A0 (no) |
MX (1) | MX2008000891A (no) |
NO (1) | NO20080025L (no) |
TW (1) | TW200734324A (no) |
UY (1) | UY29678A1 (no) |
WO (1) | WO2007010217A1 (no) |
ZA (1) | ZA200800327B (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101472897A (zh) * | 2006-06-20 | 2009-07-01 | 阿斯利康(瑞典)有限公司 | 治疗剂 |
US20100234439A1 (en) * | 2006-06-20 | 2010-09-16 | Leifeng Cheng | Therapeutic agents |
EP1946777A1 (en) * | 2007-01-16 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline for preventing weight gain |
ES2341522B1 (es) * | 2008-12-18 | 2011-06-06 | Laboratorios Del Dr. Esteve, S.A. | Compuestos de pirazolina sustituida en la posicion, 4 preparacion y composiciones farmaceuticas que comprenden los mismos. |
US9133128B2 (en) | 2011-06-17 | 2015-09-15 | Research Triangle Institute | Pyrazole derivatives as cannabinoid receptor 1 antagonists |
CN109516955B (zh) * | 2017-09-20 | 2022-07-26 | 华东师范大学 | 含氮五元芳香杂环化合物及其制备方法和应用 |
CN113274391B (zh) * | 2021-06-01 | 2022-07-05 | 苏州大学 | 吡唑衍生物在制备p2y6r相关治疗动脉粥样硬化及抗炎药物中的应用 |
WO2023205180A1 (en) | 2022-04-19 | 2023-10-26 | Nurix Therapeutics, Inc. | Biomarkers for cbl, and compositions and methods for their use |
WO2023250097A1 (en) | 2022-06-22 | 2023-12-28 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds and antiemetic agents |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2714057B1 (fr) * | 1993-12-17 | 1996-03-08 | Sanofi Elf | Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant. |
FR2732967B1 (fr) * | 1995-04-11 | 1997-07-04 | Sanofi Sa | 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant |
TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
EP1224173B1 (en) * | 1999-10-18 | 2005-10-12 | The University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
CA2399791A1 (en) * | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
US6825209B2 (en) * | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
FR2856683A1 (fr) * | 2003-06-25 | 2004-12-31 | Sanofi Synthelabo | Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique |
EP1718617B1 (en) * | 2004-02-20 | 2009-08-19 | AstraZeneca AB | 3-substituted 1,5-diphenylpyrazole derivatives useful as cb1 modulators |
JP2008525404A (ja) * | 2004-12-23 | 2008-07-17 | アストラゼネカ アクチボラグ | 治療剤 |
-
2005
- 2005-07-19 GB GBGB0514738.4A patent/GB0514738D0/en not_active Ceased
-
2006
- 2006-07-14 AR ARP060103029A patent/AR057461A1/es not_active Application Discontinuation
- 2006-07-17 US US11/996,115 patent/US20080287517A1/en not_active Abandoned
- 2006-07-17 WO PCT/GB2006/002631 patent/WO2007010217A1/en active Application Filing
- 2006-07-17 CN CNA2006800261058A patent/CN101223159A/zh active Pending
- 2006-07-17 EP EP06764974A patent/EP1910331A1/en not_active Withdrawn
- 2006-07-17 UY UY29678A patent/UY29678A1/es unknown
- 2006-07-17 KR KR1020087003956A patent/KR20080032206A/ko not_active Application Discontinuation
- 2006-07-17 AU AU2006271499A patent/AU2006271499A1/en not_active Abandoned
- 2006-07-17 MX MX2008000891A patent/MX2008000891A/es not_active Application Discontinuation
- 2006-07-17 JP JP2008522044A patent/JP2009501771A/ja active Pending
- 2006-07-17 CA CA002615588A patent/CA2615588A1/en not_active Abandoned
- 2006-07-18 TW TW095126223A patent/TW200734324A/zh unknown
-
2007
- 2007-12-24 IL IL188388A patent/IL188388A0/en unknown
-
2008
- 2008-01-03 NO NO20080025A patent/NO20080025L/no not_active Application Discontinuation
- 2008-01-10 ZA ZA200800327A patent/ZA200800327B/xx unknown
Also Published As
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IL188388A0 (en) | 2008-04-13 |
CA2615588A1 (en) | 2007-01-25 |
EP1910331A1 (en) | 2008-04-16 |
US20080287517A1 (en) | 2008-11-20 |
ZA200800327B (en) | 2008-12-31 |
CN101223159A (zh) | 2008-07-16 |
WO2007010217A1 (en) | 2007-01-25 |
AR057461A1 (es) | 2007-12-05 |
GB0514738D0 (en) | 2005-08-24 |
UY29678A1 (es) | 2007-02-28 |
TW200734324A (en) | 2007-09-16 |
JP2009501771A (ja) | 2009-01-22 |
AU2006271499A1 (en) | 2007-01-25 |
MX2008000891A (es) | 2008-03-18 |
KR20080032206A (ko) | 2008-04-14 |
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