NO20080025L - Pyrazolderivater som CB1 modulatorer - Google Patents
Pyrazolderivater som CB1 modulatorerInfo
- Publication number
- NO20080025L NO20080025L NO20080025A NO20080025A NO20080025L NO 20080025 L NO20080025 L NO 20080025L NO 20080025 A NO20080025 A NO 20080025A NO 20080025 A NO20080025 A NO 20080025A NO 20080025 L NO20080025 L NO 20080025L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl group
- hydroxy
- substituted
- group
- cyano
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title 1
- -1 hydroxy, fluoro, amino Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0514738.4A GB0514738D0 (en) | 2005-07-19 | 2005-07-19 | Therapeutic agents |
| PCT/GB2006/002631 WO2007010217A1 (en) | 2005-07-19 | 2006-07-17 | PYRAZOLE DERIVATIVES AS CBl MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080025L true NO20080025L (no) | 2008-04-16 |
Family
ID=34897416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080025A NO20080025L (no) | 2005-07-19 | 2008-01-03 | Pyrazolderivater som CB1 modulatorer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080287517A1 (de) |
| EP (1) | EP1910331A1 (de) |
| JP (1) | JP2009501771A (de) |
| KR (1) | KR20080032206A (de) |
| CN (1) | CN101223159A (de) |
| AR (1) | AR057461A1 (de) |
| AU (1) | AU2006271499A1 (de) |
| CA (1) | CA2615588A1 (de) |
| GB (1) | GB0514738D0 (de) |
| IL (1) | IL188388A0 (de) |
| MX (1) | MX2008000891A (de) |
| NO (1) | NO20080025L (de) |
| TW (1) | TW200734324A (de) |
| UY (1) | UY29678A1 (de) |
| WO (1) | WO2007010217A1 (de) |
| ZA (1) | ZA200800327B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100234439A1 (en) * | 2006-06-20 | 2010-09-16 | Leifeng Cheng | Therapeutic agents |
| US20100234438A1 (en) * | 2006-06-20 | 2010-09-16 | Leifeng Cheng | Therapeutic agents |
| EP1946777A1 (de) * | 2007-01-16 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substituierte Pyrazolinderivate zur Vermeidung von Gewichtszunahme |
| ES2341522B1 (es) * | 2008-12-18 | 2011-06-06 | Laboratorios Del Dr. Esteve, S.A. | Compuestos de pirazolina sustituida en la posicion, 4 preparacion y composiciones farmaceuticas que comprenden los mismos. |
| US9133128B2 (en) | 2011-06-17 | 2015-09-15 | Research Triangle Institute | Pyrazole derivatives as cannabinoid receptor 1 antagonists |
| CN109516955B (zh) * | 2017-09-20 | 2022-07-26 | 华东师范大学 | 含氮五元芳香杂环化合物及其制备方法和应用 |
| CN113274391B (zh) * | 2021-06-01 | 2022-07-05 | 苏州大学 | 吡唑衍生物在制备p2y6r相关治疗动脉粥样硬化及抗炎药物中的应用 |
| WO2023205180A1 (en) | 2022-04-19 | 2023-10-26 | Nurix Therapeutics, Inc. | Biomarkers for cbl, and compositions and methods for their use |
| WO2023250097A1 (en) | 2022-06-22 | 2023-12-28 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds and antiemetic agents |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2714057B1 (fr) * | 1993-12-17 | 1996-03-08 | Sanofi Elf | Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant. |
| FR2732967B1 (fr) * | 1995-04-11 | 1997-07-04 | Sanofi Sa | 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant |
| TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| CA2387892A1 (en) * | 1999-10-18 | 2001-04-26 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
| US6825209B2 (en) * | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
| FR2856683A1 (fr) * | 2003-06-25 | 2004-12-31 | Sanofi Synthelabo | Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique |
| US20090149463A1 (en) * | 2004-02-20 | 2009-06-11 | Leifeng Cheng | Therapeutic agents |
| EP1831177A1 (de) * | 2004-12-23 | 2007-09-12 | AstraZeneca AB | Therapeutische mittel |
-
2005
- 2005-07-19 GB GBGB0514738.4A patent/GB0514738D0/en not_active Ceased
-
2006
- 2006-07-14 AR ARP060103029A patent/AR057461A1/es not_active Application Discontinuation
- 2006-07-17 UY UY29678A patent/UY29678A1/es unknown
- 2006-07-17 MX MX2008000891A patent/MX2008000891A/es not_active Application Discontinuation
- 2006-07-17 AU AU2006271499A patent/AU2006271499A1/en not_active Abandoned
- 2006-07-17 CA CA002615588A patent/CA2615588A1/en not_active Abandoned
- 2006-07-17 KR KR1020087003956A patent/KR20080032206A/ko not_active Withdrawn
- 2006-07-17 WO PCT/GB2006/002631 patent/WO2007010217A1/en not_active Ceased
- 2006-07-17 JP JP2008522044A patent/JP2009501771A/ja active Pending
- 2006-07-17 CN CNA2006800261058A patent/CN101223159A/zh active Pending
- 2006-07-17 US US11/996,115 patent/US20080287517A1/en not_active Abandoned
- 2006-07-17 EP EP06764974A patent/EP1910331A1/de not_active Withdrawn
- 2006-07-18 TW TW095126223A patent/TW200734324A/zh unknown
-
2007
- 2007-12-24 IL IL188388A patent/IL188388A0/en unknown
-
2008
- 2008-01-03 NO NO20080025A patent/NO20080025L/no not_active Application Discontinuation
- 2008-01-10 ZA ZA200800327A patent/ZA200800327B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009501771A (ja) | 2009-01-22 |
| IL188388A0 (en) | 2008-04-13 |
| TW200734324A (en) | 2007-09-16 |
| CN101223159A (zh) | 2008-07-16 |
| US20080287517A1 (en) | 2008-11-20 |
| ZA200800327B (en) | 2008-12-31 |
| MX2008000891A (es) | 2008-03-18 |
| CA2615588A1 (en) | 2007-01-25 |
| AR057461A1 (es) | 2007-12-05 |
| WO2007010217A1 (en) | 2007-01-25 |
| UY29678A1 (es) | 2007-02-28 |
| EP1910331A1 (de) | 2008-04-16 |
| AU2006271499A1 (en) | 2007-01-25 |
| KR20080032206A (ko) | 2008-04-14 |
| GB0514738D0 (en) | 2005-08-24 |
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| FC2A | Withdrawal, rejection or dismissal of laid open patent application |