NO20076349L - Stereoselektiv syntese av aminosyreanaloger for tumorbilleddannelse - Google Patents
Stereoselektiv syntese av aminosyreanaloger for tumorbilleddannelseInfo
- Publication number
- NO20076349L NO20076349L NO20076349A NO20076349A NO20076349L NO 20076349 L NO20076349 L NO 20076349L NO 20076349 A NO20076349 A NO 20076349A NO 20076349 A NO20076349 A NO 20076349A NO 20076349 L NO20076349 L NO 20076349L
- Authority
- NO
- Norway
- Prior art keywords
- syn
- amino
- acbc
- analogs
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/84—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/04—Saturated compounds having a carboxyl group bound to a three or four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Radiomerkede ikke-naturlige aminosyre-1-amino-3-syklobutan-1-karboksylsyre (ACBC) og dens analoger er kandidattumoravbildningsmidler anvendelige for positronemisjonstomografi og enkel fotonemisjon databehandlingstomografi på grunn av deres selektive affinitet for tumorceller. Foreliggende oppfinnelse tilveiebringer også fremgangsmåter for stereoselektiv syntese av syn-ACBC-analoger. Den beskrevne syntesestrategien er pålitelig og effektiv og kan anvendes for å syntetisere en grammengde av forskjellige syn-isomerer av ACBC-analoger, særlig syn-[18F]-1-amino-3-fluorsyklobutan-1-karboksylsyre (FACBC) og syn-[123I]-1-amino-3-jodsyklobutan-1-karboksylsyre (IACBC) analoger.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69338505P | 2005-06-23 | 2005-06-23 | |
PCT/US2006/023740 WO2007001958A2 (en) | 2005-06-23 | 2006-06-19 | Stereoselective synthesis of amino acid analogs for tumor imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20076349L true NO20076349L (no) | 2008-02-15 |
Family
ID=37595707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20076349A NO20076349L (no) | 2005-06-23 | 2007-12-11 | Stereoselektiv syntese av aminosyreanaloger for tumorbilleddannelse |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060292073A1 (no) |
EP (1) | EP1893246A4 (no) |
JP (1) | JP5349960B2 (no) |
AU (1) | AU2006262425C1 (no) |
CA (1) | CA2612187C (no) |
NO (1) | NO20076349L (no) |
RU (1) | RU2376282C2 (no) |
WO (1) | WO2007001958A2 (no) |
Families Citing this family (29)
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EP1893244A4 (en) * | 2005-06-23 | 2009-06-24 | Univ Emory | CONTRAST AGENTS |
AU2006319987B2 (en) | 2005-11-29 | 2012-09-06 | Nihon Medi-Physics Co., Ltd. | Precursor compound of radioactive halogen labeled organic compound |
JPWO2008056481A1 (ja) * | 2006-11-09 | 2010-02-25 | 日本メジフィジックス株式会社 | 放射性画像診断剤 |
CN101563107B (zh) * | 2006-12-21 | 2012-07-11 | 日本医事物理股份有限公司 | 放射性诊断显像剂 |
NO345488B1 (no) * | 2006-12-27 | 2021-03-01 | Nihon Mediphysics Co Ltd | Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse |
EP2119458B9 (en) | 2007-02-13 | 2013-08-21 | Nihon Medi-Physics Co., Ltd. | Method for production of radiation diagnostic imaging agent |
PE20090222A1 (es) * | 2007-05-04 | 2009-03-27 | Bristol Myers Squibb Co | Compuestos [6,6] y [6,7]-biciclicos como agonistas del receptor acoplado a la proteina g gpr119 |
CN101668759A (zh) | 2007-05-04 | 2010-03-10 | 百时美施贵宝公司 | [6,5]-双环gpr119g蛋白-偶合受体激动剂 |
PT2173737E (pt) | 2007-07-17 | 2012-03-19 | Bristol Myers Squibb Co | Método para modular receptor gpr119 acoplado a proteína g e compostos seleccionados |
US8258313B2 (en) * | 2007-07-19 | 2012-09-04 | Tokuyama Corporation | Compound having hydantoin ring and method of producing the same |
ES2610574T3 (es) * | 2007-12-19 | 2017-04-28 | Nihon Medi-Physics Co., Ltd. | Procedimiento para producir un compuesto orgánico marcado con flúor radiactivo |
US8246752B2 (en) | 2008-01-25 | 2012-08-21 | Clear Catheter Systems, Inc. | Methods and devices to clear obstructions from medical tubes |
EP2271372A4 (en) * | 2008-04-14 | 2012-12-19 | Univ Emory | IMAGING AGENT |
TW201006821A (en) | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
JP2012532834A (ja) | 2009-07-11 | 2012-12-20 | バイエル ファーマ アクチエンゲゼルシャフト | シクロアルキル基を用いる放射性標識方法 |
JPWO2011040574A1 (ja) * | 2009-09-30 | 2013-02-28 | 国立大学法人京都大学 | アゼチジニルメトキシピリジン誘導体の製造方法及びその使用 |
EA201270755A1 (ru) | 2010-04-08 | 2013-03-29 | Бристол-Майерс Сквибб Компани | Аналоги пиримидинилпиперидинилоксипиридинона в качестве модуляторов рецептора gpr119 |
EP2392568A1 (en) | 2010-06-04 | 2011-12-07 | Bayer Pharma Aktiengesellschaft | Heterocyclic amino acids for prostate cancer imaging |
GB201021530D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Purification of precursor compound by crystallisation |
WO2012110519A1 (de) * | 2011-02-17 | 2012-08-23 | Bayer Cropscience Ag | Substituierte 3-(biphenyl-3-yl)-8,8-difluor-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one zur therapie und halogensubstituierte spirocyclische ketoenole |
ES2549061T3 (es) * | 2011-03-11 | 2015-10-22 | Bayer Intellectual Property Gmbh | Derivados de 1H-pirrolidina-2,4-diona espirocíclicos cis-alcoxi-sustituidos |
ES2710564T3 (es) * | 2011-07-21 | 2019-04-25 | Ge Healthcare Ltd | Compuestos precursores y métodos para preparar los mismos |
GB201411569D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
GB201305687D0 (en) * | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
CA2913958A1 (en) | 2013-06-03 | 2014-12-11 | Bayer Pharma Aktiengesellschaft | Substituted benzoxazoles |
UY35592A (es) | 2013-06-03 | 2014-12-31 | Bayer Pharma AG | Benzoxazoles sustituidos |
CN111574389B (zh) * | 2020-05-14 | 2023-08-18 | 河北威远生物化工有限公司 | 1-氨基-4-取代环己基羧酸及其盐的顺式异构体的制备方法 |
CN114031652B (zh) * | 2021-11-04 | 2023-05-26 | 北京师范大学 | 一种含环己烷的葡萄糖衍生物及其应用 |
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GB0121439D0 (en) * | 2001-09-05 | 2001-10-24 | Univ St Andrews | An enzymatic process for the generation of organo-fluorine compounds |
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EP1893244A4 (en) * | 2005-06-23 | 2009-06-24 | Univ Emory | CONTRAST AGENTS |
-
2006
- 2006-06-19 WO PCT/US2006/023740 patent/WO2007001958A2/en active Application Filing
- 2006-06-19 AU AU2006262425A patent/AU2006262425C1/en not_active Ceased
- 2006-06-19 CA CA2612187A patent/CA2612187C/en not_active Expired - Fee Related
- 2006-06-19 EP EP06785079A patent/EP1893246A4/en not_active Withdrawn
- 2006-06-19 JP JP2008518271A patent/JP5349960B2/ja not_active Expired - Fee Related
- 2006-06-19 US US11/425,051 patent/US20060292073A1/en not_active Abandoned
- 2006-06-19 RU RU2008100844/04A patent/RU2376282C2/ru not_active IP Right Cessation
-
2007
- 2007-12-11 NO NO20076349A patent/NO20076349L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2007001958A3 (en) | 2007-05-31 |
EP1893246A4 (en) | 2009-05-06 |
JP5349960B2 (ja) | 2013-11-20 |
US20060292073A1 (en) | 2006-12-28 |
JP2008546783A (ja) | 2008-12-25 |
AU2006262425A1 (en) | 2007-01-04 |
RU2376282C2 (ru) | 2009-12-20 |
AU2006262425C1 (en) | 2012-06-21 |
AU2006262425B2 (en) | 2011-12-08 |
EP1893246A2 (en) | 2008-03-05 |
CA2612187C (en) | 2013-05-07 |
WO2007001958A2 (en) | 2007-01-04 |
RU2008100844A (ru) | 2009-07-27 |
CA2612187A1 (en) | 2007-01-04 |
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