NO20076219L - Farmasoytisk formulering med apomorfin for bukkal administrering - Google Patents

Farmasoytisk formulering med apomorfin for bukkal administrering

Info

Publication number
NO20076219L
NO20076219L NO20076219A NO20076219A NO20076219L NO 20076219 L NO20076219 L NO 20076219L NO 20076219 A NO20076219 A NO 20076219A NO 20076219 A NO20076219 A NO 20076219A NO 20076219 L NO20076219 L NO 20076219L
Authority
NO
Norway
Prior art keywords
apomorphine
buccal administration
pharmaceutical formulation
formulation
pharmaceutically acceptable
Prior art date
Application number
NO20076219A
Other languages
English (en)
Other versions
NO339404B1 (no
Inventor
Anthony Clarke
Original Assignee
Amarin Pharmaceuticals Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amarin Pharmaceuticals Ireland filed Critical Amarin Pharmaceuticals Ireland
Publication of NO20076219L publication Critical patent/NO20076219L/no
Publication of NO339404B1 publication Critical patent/NO339404B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Den foreliggende oppfinnelse tilveiebringer et sett som omfatter, i separate avdelinger i en beholder, følgende komponenter (a) og (b): (a) en kombinasjon av apomorfin eller et farmasøytisk akseptabelt syreaddisjonssalt derav og en farmasøytisk akseptabel eksipient eller bærer; og (b) en løsning som omfatter et fortynningsmiddel og et pH-modifiserende middel; hvor komponentene er presentert slik at de kan kombineres på tidspunktet for anvendelse til en formulering som er justert til en pH som varierer fra svakt sur til alkalisk og som er egnet for bukal administrering. Formuleringen er nyttig til å behandle Parkinsons sykdom og til å fremme seksuell fiinksjon.
NO20076219A 2005-05-06 2007-12-03 Farmasøytisk formulering med apomorfin for bukkal administrering NO339404B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0509317.4A GB0509317D0 (en) 2005-05-06 2005-05-06 Pharmaceutical formulation of apomorphine
PCT/GB2006/001665 WO2006120412A1 (en) 2005-05-06 2006-05-08 Pharmaceutical formulation of apomorphine for buccal administration

Publications (2)

Publication Number Publication Date
NO20076219L true NO20076219L (no) 2007-12-03
NO339404B1 NO339404B1 (no) 2016-12-12

Family

ID=34685218

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076219A NO339404B1 (no) 2005-05-06 2007-12-03 Farmasøytisk formulering med apomorfin for bukkal administrering

Country Status (21)

Country Link
US (2) US20090023766A1 (no)
EP (1) EP1885333B1 (no)
JP (1) JP5116665B2 (no)
KR (1) KR101365458B1 (no)
CN (1) CN101217936A (no)
AT (1) ATE545407T1 (no)
AU (1) AU2006245564A1 (no)
BR (1) BRPI0611258A2 (no)
CA (1) CA2607802C (no)
DK (1) DK1885333T3 (no)
ES (1) ES2383433T3 (no)
GB (1) GB0509317D0 (no)
HK (1) HK1113086A1 (no)
IL (1) IL187183A0 (no)
MX (1) MX2007013890A (no)
NO (1) NO339404B1 (no)
PT (1) PT1885333E (no)
RU (1) RU2007140701A (no)
SI (1) SI1885333T1 (no)
WO (1) WO2006120412A1 (no)
ZA (1) ZA200709474B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0819530D0 (en) * 2008-10-24 2008-12-03 Univ Sheffield Methods and compositions
DK2442650T3 (en) 2009-06-12 2015-12-07 Cynapsus Therapeutics Inc sublingual apomorphine
NZ612686A (en) 2010-12-16 2015-11-27 Cynapsus Therapeutics Inc Sublingual films
EP2545788A1 (de) * 2011-07-13 2013-01-16 Martin Hulliger Diätisches Mehrkomponentensystem
WO2013181331A2 (en) * 2012-05-30 2013-12-05 Ibh Ventures, Llc Polyphenol-reactive oxygen species compositions and methods
CN104349768B (zh) 2012-06-05 2017-11-07 纽罗德姆有限公司 包含阿朴吗啡和有机酸的组合物及其用途
MX2016006087A (es) 2013-11-11 2016-08-12 Impax Laboratories Inc Formulaciones de desintegracion rapida y metodos de uso.
JP6042794B2 (ja) * 2013-12-03 2016-12-14 本田技研工業株式会社 車両制御方法
WO2016022816A1 (en) * 2014-08-07 2016-02-11 Mucodel Pharma Llc Chemically stable and oromucosally absorbable gel compositions of a pharmaceutical active agent in a multi-chambered delivery system
US10493027B2 (en) 2014-08-07 2019-12-03 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi- chambered delivery system for mucosal delivery
JP7211706B2 (ja) 2015-04-21 2023-01-24 サノヴィオン ファーマシュティカルズ インコーポレーテッド 口腔粘膜へのアポモルフィンの投与によるパーキンソン病の治療方法
AU2016333486B2 (en) 2015-09-28 2022-02-03 Ever Neuro Pharma Gmbh Aqueous composition of apomorphine for subcutaneous administration
WO2018148382A1 (en) * 2017-02-10 2018-08-16 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi-chambered delivery system for mucosal delivery
GB201912686D0 (en) * 2019-09-04 2019-10-16 Reown Pharma Inc Pharmaceutical composition
WO2023012736A1 (en) * 2021-08-05 2023-02-09 Zydus Lifesciences Limited Stable pharmaceutical compositions of apomorphine
WO2023242355A1 (en) 2022-06-15 2023-12-21 Ever Neuro Pharma Gmbh Apomorphine prodrugs and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022445A2 (en) * 1993-03-26 1994-10-13 Merkus Franciscus W H M Pharmaceutical compositions for intranasal administration of dihydroergotamine, apomorphine and morphine
US6121276A (en) * 1994-04-22 2000-09-19 Pentech Pharmaceuticals, Inc. Apomorphine-containing dosage forms for ameliorating male erectile dysfunction
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
WO1998048784A2 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis
US6436950B1 (en) * 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
BR0012822A (pt) * 1999-12-30 2004-03-09 Tap Holdings Inc Formulação farmacêutica, e, forma de dosagem em tablete
CN1441794A (zh) * 2000-07-13 2003-09-10 武田药品工业株式会社 富脂质斑退化剂
US20040028613A1 (en) * 2001-06-25 2004-02-12 Nastech Pharmaceutical Company Inc Dopamine agonist formulations for enhanced central nervous system delivery
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
JP2005537244A (ja) * 2002-06-28 2005-12-08 ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド 療法化合物の粘膜搬送を増進させるための、上皮接合部接着分子の生理機能を調節する組成物および方法
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
US20040126448A1 (en) * 2002-08-05 2004-07-01 Nils-Olof Lindberg Sexual dysfunction compounds
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution

Also Published As

Publication number Publication date
AU2006245564A1 (en) 2006-11-16
KR20080016608A (ko) 2008-02-21
JP2008540392A (ja) 2008-11-20
ES2383433T3 (es) 2012-06-21
RU2007140701A (ru) 2009-06-20
SI1885333T1 (sl) 2012-07-31
US8772309B2 (en) 2014-07-08
US20130131098A1 (en) 2013-05-23
BRPI0611258A2 (pt) 2010-11-23
CN101217936A (zh) 2008-07-09
US20090023766A1 (en) 2009-01-22
KR101365458B1 (ko) 2014-02-19
MX2007013890A (es) 2008-04-04
ZA200709474B (en) 2008-12-31
WO2006120412A1 (en) 2006-11-16
NO339404B1 (no) 2016-12-12
HK1113086A1 (en) 2008-09-26
GB0509317D0 (en) 2005-06-15
DK1885333T3 (da) 2012-05-14
PT1885333E (pt) 2012-05-14
EP1885333B1 (en) 2012-02-15
CA2607802C (en) 2015-02-10
EP1885333A1 (en) 2008-02-13
ATE545407T1 (de) 2012-03-15
IL187183A0 (en) 2008-02-09
JP5116665B2 (ja) 2013-01-09
CA2607802A1 (en) 2006-11-16

Similar Documents

Publication Publication Date Title
NO20076219L (no) Farmasoytisk formulering med apomorfin for bukkal administrering
BRPI0611705A2 (pt) composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto
IL184898A0 (en) Pyrrolopyrimidine derivatives and pharmaceutical compositions containing the same
TW200639159A (en) Treatment of pain
ATE470443T1 (de) Indol-1-yl-essigsäurederivate
TW200728305A (en) Spiropiperidine beta-sectetase inhibitors for the treatment of alzheimer's disease
EA200970287A1 (ru) Способы, соединения, композиции и носители, подходящие для доставки 3-амино-1-пропансульфоновой кислоты
MY143795A (en) Tetrahydropyridoindole derivatives
EA200870302A1 (ru) 1,3-диоксанкарбоновые кислоты
EA200602016A1 (ru) ПОРОШКОВЫЕ КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ
EA200971107A1 (ru) Катехоламиновые производные, полезные для лечения болезни паркинсона
RU2009120992A (ru) Применение 3-андростандиола, необязательно в сочетании с агонистом 5-ht1а для лечения сексуальной дисфункции
SG151336A1 (en) 1,3,4-oxadiazol-2-ones as ppar delta
WO2007064448A3 (en) Cancer treatment using fts and 2-deoxyglucose
IL179206A0 (en) Pyrrolylpyrimidine derivatives and pharmaceutical compositions containing the same
RU2009111378A (ru) Терапевтические композиции, содержащие специфический антагонист рецептора эндотелина и ингибиторов pde5
MXPA05014201A (es) Pirazolo [3,4-b] piridin-6-onas como inhibidores de la gsk-3.
TW200800984A (en) New compounds
AU2020278236A8 (en) Methods of treating Sjögren's Syndrome using a Bruton's tyrosine kinase inhibitor
TW200640465A (en) New pharmaceutically active compounds for the treatment of respiratory diseases
WO2007113243A3 (en) Use of pde 5 inhibitors for the treatment of overactive bladder
BRPI0509667B8 (pt) composto, processo para a preparação de um composto de fórmula (i), medicamento e uso de um composto
TW200635925A (en) Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
BRPI0512151A (pt) solução concentrada de sal de sódio monoidratado do tenatoprazol, composição farmacêutica, utilização do sal de sódio monoidratado do tenatoprazol, processo de preparação do sal de sódio monoidratado do tenatoprazol, e composição para administração por via oral do sal de sódio monoidratado do tenatoprazol
UA95780C2 (en) Xanthine derivatives as selective hm74a agonists

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees