ATE545407T1 - Pharmazeutische formulierung von apomorphin für die bukkale verabreichung - Google Patents

Pharmazeutische formulierung von apomorphin für die bukkale verabreichung

Info

Publication number
ATE545407T1
ATE545407T1 AT06727033T AT06727033T ATE545407T1 AT E545407 T1 ATE545407 T1 AT E545407T1 AT 06727033 T AT06727033 T AT 06727033T AT 06727033 T AT06727033 T AT 06727033T AT E545407 T1 ATE545407 T1 AT E545407T1
Authority
AT
Austria
Prior art keywords
apomorphine
buccal administration
pharmaceutical formulation
formulation
pharmaceutically acceptable
Prior art date
Application number
AT06727033T
Other languages
English (en)
Inventor
Anthony Clarke
Original Assignee
Amarin Pharmaceuticals Ie Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amarin Pharmaceuticals Ie Ltd filed Critical Amarin Pharmaceuticals Ie Ltd
Application granted granted Critical
Publication of ATE545407T1 publication Critical patent/ATE545407T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT06727033T 2005-05-06 2006-05-08 Pharmazeutische formulierung von apomorphin für die bukkale verabreichung ATE545407T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0509317.4A GB0509317D0 (en) 2005-05-06 2005-05-06 Pharmaceutical formulation of apomorphine
PCT/GB2006/001665 WO2006120412A1 (en) 2005-05-06 2006-05-08 Pharmaceutical formulation of apomorphine for buccal administration

Publications (1)

Publication Number Publication Date
ATE545407T1 true ATE545407T1 (de) 2012-03-15

Family

ID=34685218

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06727033T ATE545407T1 (de) 2005-05-06 2006-05-08 Pharmazeutische formulierung von apomorphin für die bukkale verabreichung

Country Status (20)

Country Link
US (2) US20090023766A1 (de)
EP (1) EP1885333B1 (de)
JP (1) JP5116665B2 (de)
KR (1) KR101365458B1 (de)
CN (1) CN101217936A (de)
AT (1) ATE545407T1 (de)
AU (1) AU2006245564A1 (de)
BR (1) BRPI0611258A2 (de)
CA (1) CA2607802C (de)
DK (1) DK1885333T3 (de)
ES (1) ES2383433T3 (de)
GB (1) GB0509317D0 (de)
IL (1) IL187183A0 (de)
MX (1) MX2007013890A (de)
NO (1) NO339404B1 (de)
PT (1) PT1885333E (de)
RU (1) RU2007140701A (de)
SI (1) SI1885333T1 (de)
WO (1) WO2006120412A1 (de)
ZA (1) ZA200709474B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0819530D0 (en) * 2008-10-24 2008-12-03 Univ Sheffield Methods and compositions
HUE028121T2 (en) 2009-06-12 2016-11-28 Cynapsus Therapeutics Inc Sublingual apomorphine
KR102161392B1 (ko) * 2010-12-16 2020-10-05 선오비온 파마슈티컬스 인코포레이티드 설하 필름
EP2545788A1 (de) * 2011-07-13 2013-01-16 Martin Hulliger Diätisches Mehrkomponentensystem
WO2013181331A2 (en) * 2012-05-30 2013-12-05 Ibh Ventures, Llc Polyphenol-reactive oxygen species compositions and methods
MX2014014902A (es) 2012-06-05 2015-03-04 Neuroderm Ltd Composiciones que comprenden apomorfina y acidos organicos y usos de las mismas.
KR20160108828A (ko) 2013-11-11 2016-09-20 임팩스 라보라토리즈, 인코포레이티드 신속하게 붕괴되는 제형 및 사용 방법
JP6042794B2 (ja) * 2013-12-03 2016-12-14 本田技研工業株式会社 車両制御方法
EP3177270A4 (de) * 2014-08-07 2018-01-24 Mucodel Pharma LLC Chemisch stabile und oromukusal absorbierbare gelzusammensetzungen eines wirkstoffes in einem mehrkammerabgabesystem
US10493027B2 (en) 2014-08-07 2019-12-03 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi- chambered delivery system for mucosal delivery
PT3285771T (pt) 2015-04-21 2025-03-31 Sunovion Pharmaceuticals Inc Métodos de tratamento da doença de parkinson pela administração de apomorfina a uma mucosa oral
AU2016333486B2 (en) 2015-09-28 2022-02-03 Ever Neuro Pharma Gmbh Aqueous composition of apomorphine for subcutaneous administration
WO2018148382A1 (en) * 2017-02-10 2018-08-16 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi-chambered delivery system for mucosal delivery
GB201912686D0 (en) 2019-09-04 2019-10-16 Reown Pharma Inc Pharmaceutical composition
US20240335379A1 (en) * 2021-08-05 2024-10-10 Zydus Lifesciences Limited Stable pharmaceutical compositions of apomorphine
US20250361252A1 (en) 2022-06-15 2025-11-27 Ever Neuro Pharma Gmbh Apomorphine prodrugs and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0689438T3 (da) * 1993-03-26 2003-09-29 Franciscus Wilhelmus He Merkus Farmaceutiske præparater til intranasal administration af apomorfin
US6121276A (en) * 1994-04-22 2000-09-19 Pentech Pharmaceuticals, Inc. Apomorphine-containing dosage forms for ameliorating male erectile dysfunction
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
CA2285948A1 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis
US6436950B1 (en) * 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
PL366204A1 (en) * 1999-12-30 2005-01-24 Tap Holdings, Inc. Oral mucosal dosage forms of apomorphine
CA2429008A1 (en) * 2000-07-13 2003-01-09 Takeda Chemical Industries, Ltd. Lipid-rich plaque regressing agents
US20040028613A1 (en) * 2001-06-25 2004-02-12 Nastech Pharmaceutical Company Inc Dopamine agonist formulations for enhanced central nervous system delivery
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
AU2003279750A1 (en) * 2002-06-28 2004-01-19 Nastech Pharmaceutical Company Inc. Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
US20040126448A1 (en) * 2002-08-05 2004-07-01 Nils-Olof Lindberg Sexual dysfunction compounds
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution

Also Published As

Publication number Publication date
CA2607802A1 (en) 2006-11-16
RU2007140701A (ru) 2009-06-20
IL187183A0 (en) 2008-02-09
NO20076219L (no) 2007-12-03
DK1885333T3 (da) 2012-05-14
WO2006120412A1 (en) 2006-11-16
KR101365458B1 (ko) 2014-02-19
JP5116665B2 (ja) 2013-01-09
EP1885333A1 (de) 2008-02-13
PT1885333E (pt) 2012-05-14
AU2006245564A1 (en) 2006-11-16
KR20080016608A (ko) 2008-02-21
CN101217936A (zh) 2008-07-09
HK1113086A1 (en) 2008-09-26
JP2008540392A (ja) 2008-11-20
CA2607802C (en) 2015-02-10
SI1885333T1 (sl) 2012-07-31
GB0509317D0 (en) 2005-06-15
ES2383433T3 (es) 2012-06-21
MX2007013890A (es) 2008-04-04
US20090023766A1 (en) 2009-01-22
NO339404B1 (no) 2016-12-12
US20130131098A1 (en) 2013-05-23
EP1885333B1 (de) 2012-02-15
ZA200709474B (en) 2008-12-31
US8772309B2 (en) 2014-07-08
BRPI0611258A2 (pt) 2010-11-23

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