NO20075643L - Fremgangsmater for fremstilling av 3-cyano-kinoliner og derved fremstilte mellomprodukter - Google Patents
Fremgangsmater for fremstilling av 3-cyano-kinoliner og derved fremstilte mellomprodukterInfo
- Publication number
- NO20075643L NO20075643L NO20075643A NO20075643A NO20075643L NO 20075643 L NO20075643 L NO 20075643L NO 20075643 A NO20075643 A NO 20075643A NO 20075643 A NO20075643 A NO 20075643A NO 20075643 L NO20075643 L NO 20075643L
- Authority
- NO
- Norway
- Prior art keywords
- methods
- cyanoquinolines
- preparation
- prepared intermediates
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
- C07C257/06—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms, or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår metoder for fremstilling av substituerte 3-cyanokinoliner og mellomprodukter oppnådd ved metodene ifølge foreliggende oppfinnelse. Metodene ifølge oppfinnelsen omfatter omsetning av et N-aryl-2-propanimid med fosforylklorid for å produsere de substituerte 3-cyanokinoliner. Metodene omfatter videre omsetning av arylaminer, ortoformiater og aktive metylener for å produsere N-aryl-2-propenamid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68468305P | 2005-05-25 | 2005-05-25 | |
PCT/US2006/016019 WO2006127205A2 (en) | 2005-05-25 | 2006-04-27 | Methods of preparing 3-cyano-quinolines and intermediates made thereby |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20075643L true NO20075643L (no) | 2008-02-21 |
Family
ID=36845416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075643A NO20075643L (no) | 2005-05-25 | 2007-11-06 | Fremgangsmater for fremstilling av 3-cyano-kinoliner og derved fremstilte mellomprodukter |
Country Status (15)
Country | Link |
---|---|
US (1) | US20060270669A1 (no) |
EP (1) | EP1883621A2 (no) |
JP (1) | JP2008542267A (no) |
KR (1) | KR20080016600A (no) |
CN (1) | CN101180269A (no) |
AU (1) | AU2006249598A1 (no) |
BR (1) | BRPI0610144A2 (no) |
CA (1) | CA2608394A1 (no) |
CR (1) | CR9508A (no) |
IL (1) | IL187303A0 (no) |
MX (1) | MX2007014773A (no) |
NO (1) | NO20075643L (no) |
RU (1) | RU2007139544A (no) |
WO (1) | WO2006127205A2 (no) |
ZA (1) | ZA200710163B (no) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006210572B2 (en) | 2005-02-03 | 2011-08-04 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
US8022216B2 (en) * | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
CA2725598C (en) | 2008-06-17 | 2013-10-08 | Wyeth Llc | Antineoplastic combinations containing hki-272 and vinorelbine |
WO2010017163A1 (en) | 2008-08-04 | 2010-02-11 | Wyeth | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
KR20140036332A (ko) | 2009-04-06 | 2014-03-25 | 와이어쓰 엘엘씨 | 네라티닙을 이용한 유방암의 치료법 |
CA2780332C (en) * | 2009-11-09 | 2018-01-30 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
CN102649778A (zh) * | 2011-02-23 | 2012-08-29 | 苏州波锐生物医药科技有限公司 | 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
CN102718749A (zh) * | 2011-03-30 | 2012-10-10 | 北京德众万全药物技术开发有限公司 | 抗肿瘤药物诺那替尼的制备方法 |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
JP2016510000A (ja) | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
CA2928658A1 (en) | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CN103788067A (zh) * | 2014-01-14 | 2014-05-14 | 北京万全德众医药生物技术有限公司 | 一种3-[3-乙氧基-4-(n-邻苯二甲先亚胺基)]苯氨基-n-[3-氯-4-(2-吡啶基甲氧基)]苯基-2-氰基-2-丙烯酰胺的制备方法 |
CN105367552A (zh) * | 2015-01-09 | 2016-03-02 | 苏州晶云药物科技有限公司 | 来那替尼马来酸盐的新晶型及其制备方法 |
US20200308141A1 (en) * | 2016-06-27 | 2020-10-01 | Pliva Hrvatska D.O.O. | Solid state forms of neratinib and salts thereof |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
AU2017324251A1 (en) | 2016-09-08 | 2019-03-21 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CN106905234B (zh) * | 2017-04-12 | 2019-04-23 | 淮海工学院 | 一种合成来那替尼中间体3-氰基-4-氯-6-氨基-7-乙氧基喹啉的方法 |
CN107501174A (zh) * | 2017-07-25 | 2017-12-22 | 广州大学 | 一种喹啉衍生物的合成方法 |
CA3079277A1 (en) * | 2017-10-18 | 2019-04-25 | Jiangsu Hengrui Medicine Co., Ltd. | Preparation method for tyrosine kinase inhibitor and intermediate thereof |
CN108084085B (zh) * | 2017-12-28 | 2019-11-26 | 山东铂源药业有限公司 | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2-氰基乙酰胺的制备方法 |
CN110357854A (zh) * | 2018-03-26 | 2019-10-22 | 江苏创诺制药有限公司 | 一种来那替尼的制备方法 |
RS65621B1 (sr) | 2018-04-18 | 2024-07-31 | Constellation Pharmaceuticals Inc | Modulatori enzima koji modifikuju metil, sastavi i njihova upotreba |
WO2019226491A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
CN110818619B (zh) * | 2019-12-13 | 2021-03-02 | 山东铂源药业有限公司 | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 |
CN113336742B (zh) * | 2021-06-29 | 2022-05-10 | 山东金吉利新材料有限公司 | 一种马来酸吡咯替尼中间体的合成方法 |
CN114736154B (zh) * | 2022-03-15 | 2023-07-21 | 安庆朗坤药业有限公司 | N-(3-氯-4-(2-吡啶甲氧基)苯基)-2-氰基乙酰胺的制备方法 |
CN115124452B (zh) * | 2022-05-26 | 2024-03-01 | 安庆朗坤药业有限公司 | 一种2-(4-氨基-2-乙氧基苯基)异吲哚-1,3-二酮的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
MXPA04007495A (es) * | 2002-02-05 | 2004-11-10 | Wyeth Corp | Proceso para sintesis de acidos n-acil2-amino-4-alcoxi-5-nitrobenzoicos. |
CL2004000016A1 (es) * | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
SG145744A1 (en) * | 2003-08-19 | 2008-09-29 | Wyeth Corp | Process for the preparation of 4-amino-3- quinolinecarbonitriles |
EP1711467A2 (en) * | 2004-01-16 | 2006-10-18 | Wyeth | Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof |
-
2006
- 2006-04-27 EP EP06751635A patent/EP1883621A2/en not_active Withdrawn
- 2006-04-27 MX MX2007014773A patent/MX2007014773A/es unknown
- 2006-04-27 CN CNA2006800181320A patent/CN101180269A/zh active Pending
- 2006-04-27 KR KR1020077028326A patent/KR20080016600A/ko not_active Application Discontinuation
- 2006-04-27 AU AU2006249598A patent/AU2006249598A1/en not_active Abandoned
- 2006-04-27 RU RU2007139544/04A patent/RU2007139544A/ru not_active Application Discontinuation
- 2006-04-27 BR BRPI0610144-5A patent/BRPI0610144A2/pt not_active IP Right Cessation
- 2006-04-27 JP JP2008513497A patent/JP2008542267A/ja not_active Withdrawn
- 2006-04-27 CA CA002608394A patent/CA2608394A1/en not_active Abandoned
- 2006-04-27 WO PCT/US2006/016019 patent/WO2006127205A2/en active Application Filing
- 2006-05-25 US US11/442,561 patent/US20060270669A1/en not_active Abandoned
-
2007
- 2007-11-06 NO NO20075643A patent/NO20075643L/no not_active Application Discontinuation
- 2007-11-09 CR CR9508A patent/CR9508A/es not_active Application Discontinuation
- 2007-11-11 IL IL187303A patent/IL187303A0/en unknown
- 2007-11-26 ZA ZA200710163A patent/ZA200710163B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL187303A0 (en) | 2008-04-13 |
EP1883621A2 (en) | 2008-02-06 |
WO2006127205A2 (en) | 2006-11-30 |
KR20080016600A (ko) | 2008-02-21 |
JP2008542267A (ja) | 2008-11-27 |
BRPI0610144A2 (pt) | 2010-06-01 |
CN101180269A (zh) | 2008-05-14 |
US20060270669A1 (en) | 2006-11-30 |
CA2608394A1 (en) | 2006-11-30 |
CR9508A (es) | 2009-06-25 |
ZA200710163B (en) | 2008-12-31 |
AU2006249598A1 (en) | 2006-11-30 |
MX2007014773A (es) | 2008-02-20 |
RU2007139544A (ru) | 2009-06-27 |
WO2006127205A3 (en) | 2007-05-10 |
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