CN110818619B - 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 - Google Patents
一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 Download PDFInfo
- Publication number
- CN110818619B CN110818619B CN201911279772.2A CN201911279772A CN110818619B CN 110818619 B CN110818619 B CN 110818619B CN 201911279772 A CN201911279772 A CN 201911279772A CN 110818619 B CN110818619 B CN 110818619B
- Authority
- CN
- China
- Prior art keywords
- chloro
- pyridylmethoxy
- phenyl
- cyanoacetamide
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911279772.2A CN110818619B (zh) | 2019-12-13 | 2019-12-13 | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911279772.2A CN110818619B (zh) | 2019-12-13 | 2019-12-13 | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110818619A CN110818619A (zh) | 2020-02-21 |
CN110818619B true CN110818619B (zh) | 2021-03-02 |
Family
ID=69545261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911279772.2A Active CN110818619B (zh) | 2019-12-13 | 2019-12-13 | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110818619B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114736154B (zh) * | 2022-03-15 | 2023-07-21 | 安庆朗坤药业有限公司 | N-(3-氯-4-(2-吡啶甲氧基)苯基)-2-氰基乙酰胺的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001022966A1 (en) * | 1999-09-30 | 2001-04-05 | Smithkline Beecham Corporation | Caspases and apoptosis |
CN101180269A (zh) * | 2005-05-25 | 2008-05-14 | 惠氏公司 | 制备3-氰基-喹啉的方法和由其制得的中间体 |
CN105330646A (zh) * | 2015-12-04 | 2016-02-17 | 上海勋和医药科技有限公司 | 一种抗肿瘤药马来酸来那替尼的制备方法 |
-
2019
- 2019-12-13 CN CN201911279772.2A patent/CN110818619B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001022966A1 (en) * | 1999-09-30 | 2001-04-05 | Smithkline Beecham Corporation | Caspases and apoptosis |
CN101180269A (zh) * | 2005-05-25 | 2008-05-14 | 惠氏公司 | 制备3-氰基-喹啉的方法和由其制得的中间体 |
CN105330646A (zh) * | 2015-12-04 | 2016-02-17 | 上海勋和医药科技有限公司 | 一种抗肿瘤药马来酸来那替尼的制备方法 |
Non-Patent Citations (4)
Title |
---|
66. Nitrosonium Ion Induced Preparation of Amides from Alkyl(Aryl-alkyl) Halides with Nitriles, a Mild and selective Ritter-Type Reaction.《Synthesis》.1979,(第4期),274-276. * |
Chemoselective palladium-catalyzed deprotonative arylation/[1,2]-Wittig rearrangement of pyridylmethyl ethers;Feng Gao等;《Chemical Science》;20151027;第7卷;976-983 * |
George A. Olah等.Synthetic Methods and Reactions * |
Reaction of Alkyl Halides and Alkyl Methyl Ethers with Nitronium Tetrafluoroborate in Acetonitrile;Robert D. Bach等;《J. Org. Chem.》;19791231;第44卷(第10期);1739-1740 * |
Also Published As
Publication number | Publication date |
---|---|
CN110818619A (zh) | 2020-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110818619B (zh) | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2氰基乙酰胺的合成方法 | |
CN111978193A (zh) | 一种8-(2-羟基苯甲酰胺基)辛酸钠及其制备方法 | |
CN114230576A (zh) | 一种瑞卢戈利的制备方法 | |
CN100591649C (zh) | R-(+)-3-氯苯丙醇的制备方法 | |
CN111533677A (zh) | 一种合成盐酸阿比朵尔中间体的方法 | |
WO2023039940A1 (zh) | 一种制备n,n,n-三特戊酰化-1,3,5-三氨基苯的方法 | |
CN116120236A (zh) | 一种6-氯-2-甲基-2h-吲唑-5-胺的制备方法 | |
CN114031516A (zh) | 一种基于锆催化剂催化合成n-酰基氨基酸表面活性剂的方法 | |
CN109232222B (zh) | 一种(e)-辛-4-烯-1,8-二酸的制备方法 | |
CN117069711A (zh) | 一种苯并噁嗪-4-酮衍生物的制备方法 | |
CN115124545B (zh) | 一种促性腺激素释放激素受体拮抗剂中间体的合成方法 | |
CN111925374A (zh) | 四嗪-呋咱环类高氮含能化合物及其合成方法 | |
CN115141183B (zh) | 心肌灌注显像剂前体的制备方法及其用途 | |
CN114751836B (zh) | 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体 | |
JP7454498B2 (ja) | サリチルアミド酢酸塩の製造方法 | |
CN117447355B (zh) | 一种米洛巴林中间体的制备方法 | |
CN115043845B (zh) | 一种西地那非的合成方法 | |
CN114907415B (zh) | 一种双(二叔丁基-4-二甲氨基苯基膦)氯化钯的制备方法 | |
CN114292297B (zh) | 一种制备抗病毒药物替诺福韦艾拉酚胺富马酸盐的方法 | |
CN114057668B (zh) | 一种氨基保护基手性2-氨基-3-(4-吗啉基苯基)丙酸的合成方法 | |
CN107573345A (zh) | 一种艾代拉利司及其中间体的制备方法 | |
CN115716809A (zh) | 6-甲基-1,3,5-三嗪-2,4-二胺及其制备方法 | |
CN114478417A (zh) | 5-对甲苯基-1,2,4-三嗪-3(2h)-酮的合成方法 | |
CN110218169B (zh) | 手性4-(n-苄氧羰基)吡咯烷酮的合成方法 | |
CN115947675A (zh) | 一种雷沙吉兰中间体及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Synthesis of N - (3-chloro-4 - (2-pyridylmethoxy) phenyl) - 2-cyanoacetamide Effective date of registration: 20221130 Granted publication date: 20210302 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: Shandong Baoyuan Pharmaceutical Co.,Ltd. Registration number: Y2022980023658 |