NO20073666L - Stabiliserte flytende polypeptidformuleringer - Google Patents
Stabiliserte flytende polypeptidformuleringerInfo
- Publication number
- NO20073666L NO20073666L NO20073666A NO20073666A NO20073666L NO 20073666 L NO20073666 L NO 20073666L NO 20073666 A NO20073666 A NO 20073666A NO 20073666 A NO20073666 A NO 20073666A NO 20073666 L NO20073666 L NO 20073666L
- Authority
- NO
- Norway
- Prior art keywords
- formulations
- antibodies
- molecular weight
- stabilized liquid
- polypeptide formulations
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000009472 formulation Methods 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 239000007788 liquid Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- -1 histidine Chemical class 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000012929 tonicity agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64863905P | 2005-01-28 | 2005-01-28 | |
| PCT/US2006/004741 WO2006081587A2 (en) | 2005-01-28 | 2006-01-27 | Stabilized liquid polypeptide formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073666L true NO20073666L (no) | 2007-10-25 |
Family
ID=36694255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073666A NO20073666L (no) | 2005-01-28 | 2007-07-17 | Stabiliserte flytende polypeptidformuleringer |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20060210557A1 (de) |
| EP (1) | EP1841456A2 (de) |
| JP (1) | JP2008528638A (de) |
| KR (1) | KR20070107079A (de) |
| CN (1) | CN101111264A (de) |
| AR (1) | AR052469A1 (de) |
| AU (1) | AU2006207901A1 (de) |
| BR (1) | BRPI0606867A2 (de) |
| CA (1) | CA2595380A1 (de) |
| CR (1) | CR9294A (de) |
| DO (1) | DOP2006000022A (de) |
| GT (1) | GT200600033A (de) |
| IL (1) | IL184341A0 (de) |
| MX (1) | MX2007009091A (de) |
| NO (1) | NO20073666L (de) |
| PA (1) | PA8661401A1 (de) |
| PE (1) | PE20061201A1 (de) |
| RU (1) | RU2007124933A (de) |
| SV (1) | SV2008002394A (de) |
| TW (1) | TW200638943A (de) |
| UY (1) | UY29350A1 (de) |
| WO (1) | WO2006081587A2 (de) |
| ZA (1) | ZA200706256B (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| EP1594969B1 (de) * | 2003-02-01 | 2015-05-20 | Janssen Sciences Ireland UC | Aktive immunisierung zur erzeugung von antikörpern gegen lösliches a-beta |
| TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| CA2582157A1 (en) * | 2004-10-05 | 2006-04-20 | Wyeth | Methods and compositions for improving recombinant protein production |
| AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| ZA200710330B (en) | 2005-06-17 | 2009-12-30 | Wyeth Corp | Methods of purifying FC region containing proteins |
| TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| AR064220A1 (es) * | 2006-12-11 | 2009-03-18 | Hoffmann La Roche | Formulacion liofilizada mab abeta |
| PL2104682T3 (pl) | 2007-01-11 | 2017-03-31 | Michael Bacher | Diagnostyka i leczenie choroby Alzheimera i innych chorób neurodegeneracyjnych |
| EP2142565A4 (de) * | 2007-03-29 | 2010-03-31 | Abbott Lab | Kristalline antikörper gegen humanes il-12 |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| ES2498040T3 (es) | 2007-07-27 | 2014-09-24 | Janssen Alzheimer Immunotherapy | Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| WO2009064838A1 (en) * | 2007-11-15 | 2009-05-22 | Amgen, Inc. | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| CA2904458C (en) * | 2007-11-30 | 2017-07-25 | Wolfgang Fraunhofer | Protein formulations and methods of making same |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| AU2008352540B2 (en) | 2008-03-14 | 2012-06-28 | Biocon Limited | A monoclonal antibody and a method thereof |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| EP2196476A1 (de) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antikörperformulierung |
| US10005830B2 (en) * | 2009-03-05 | 2018-06-26 | Ablynx N.V. | Antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| JP2012533548A (ja) * | 2009-07-14 | 2012-12-27 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 組成物における黄色形成および過酸化物形成を阻害する方法 |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| JP6073031B2 (ja) * | 2009-12-28 | 2017-02-01 | タケダ ヴァクシーンズ， インコーポレイテッド | インフルエンザ抗原のエンベロープウイルスベースのウイルス様粒子溶液を安定化させる方法 |
| RU2012131099A (ru) * | 2009-12-29 | 2014-02-10 | Ф. Хоффманн-Ля Рош Аг | Препарат антитела |
| WO2011109452A1 (en) | 2010-03-01 | 2011-09-09 | Bayer Healthcare Llc | Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI) |
| HUE042330T2 (hu) | 2010-03-31 | 2019-06-28 | Stabilitech Biopharma Ltd | Módszer alumínium adjuvánsok és alumíniummal adjuvált vakcinák megóvására |
| EP2552478B1 (de) | 2010-03-31 | 2016-12-21 | Stabilitech Ltd. | Hilfsstoffe zur stabilisierung von viralen partikeln |
| HUE026885T2 (en) | 2010-03-31 | 2016-08-29 | Stabilitech Ltd | Stabilize virus fragments |
| PL3170508T3 (pl) | 2010-06-04 | 2020-04-30 | Wyeth Llc | Preparaty szczepionek |
| RU2639386C2 (ru) | 2010-11-11 | 2017-12-21 | Эббви Байотекнолоджи Лтд. | УЛУЧШЕННЫЕ ВЫСОКОКОНЦЕТРИРОВАННЫЕ ЖИДКИЕ ПРЕПАРАТЫ АНТИТЕЛ ПРОТИВ TNF-альфа |
| EP2471554A1 (de) * | 2010-12-28 | 2012-07-04 | Hexal AG | Pharmazeutische Formulierung mit biopharmazeutischem Arzneimittel |
| EP2500035A1 (de) * | 2011-03-15 | 2012-09-19 | Icon Genetics GmbH | Pharmazeutische Formulierung mit Immunglobulin |
| SI2691112T1 (en) | 2011-03-31 | 2018-07-31 | Merck Sharp & Dohme Corp. | STABILITY FORMULATION PROTITELES FOR HUMAN PROGRAMMED DEPRESSOR RECEPTOR PD-1 AND RELATED HEALTH |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| JP2015526409A (ja) * | 2012-07-03 | 2015-09-10 | ヤンセン・サイエンシズ・アイルランド・ユーシー | Ｃ−末端及び中心エピトープａ−ベータ抗体 |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| ES2843683T3 (es) | 2013-07-23 | 2021-07-20 | Biocon Ltd | Uso de un ligando de CD6 y método basado en el mismo |
| IL275388B1 (en) | 2013-09-11 | 2024-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity reducing agents |
| GB201320660D0 (en) * | 2013-11-22 | 2014-01-08 | Qualasept Ltd | Method |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| AR104847A1 (es) | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
| DK3313879T3 (da) | 2015-06-24 | 2022-03-14 | Hoffmann La Roche | Anti-transferrinreceptor-antistoffer med tilpasset affinitet |
| MX2018003822A (es) | 2015-10-02 | 2018-06-22 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso. |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| GB201604124D0 (en) * | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
| CN107446044B (zh) * | 2016-05-30 | 2021-04-30 | 越海百奥药业(绍兴)有限公司 | 一种纯化抗体的方法及所用缓冲液 |
| AU2017307313B2 (en) * | 2016-08-02 | 2021-09-09 | Ambah Ip Limited | Stable ibuprofen injectable composition |
| PT3529274T (pt) | 2016-10-21 | 2024-06-21 | Biocon Ltd | Um anticorpo monoclonal e um método de utilização para o tratamento de lúpus |
| GB201703063D0 (en) | 2017-02-24 | 2017-04-12 | Arecor Ltd | Stabilized antibody protein solutions |
| US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
| EP3372241A1 (de) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Flüssige pharmazeutische zusammensetzung |
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| EP3618871A4 (de) | 2017-05-02 | 2021-01-06 | Merck Sharp & Dohme Corp. | Formulierungen von anti-lag3-antikörpern und co-formulierungen von anti-lag3-antikörpern und anti-pd-1-antikörpern |
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| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
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| CN112451652A (zh) * | 2020-12-07 | 2021-03-09 | 苏州智核生物医药科技有限公司 | 一种重组人促甲状腺素注射液 |
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| US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
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-
2006
- 2006-01-27 MX MX2007009091A patent/MX2007009091A/es not_active Application Discontinuation
- 2006-01-27 EP EP06734749A patent/EP1841456A2/de not_active Withdrawn
- 2006-01-27 WO PCT/US2006/004741 patent/WO2006081587A2/en active Application Filing
- 2006-01-27 PA PA20068661401A patent/PA8661401A1/es unknown
- 2006-01-27 CA CA002595380A patent/CA2595380A1/en not_active Abandoned
- 2006-01-27 DO DO2006000022A patent/DOP2006000022A/es unknown
- 2006-01-27 UY UY29350A patent/UY29350A1/es not_active Application Discontinuation
- 2006-01-27 GT GT200600033A patent/GT200600033A/es unknown
- 2006-01-27 SV SV2006002394A patent/SV2008002394A/es not_active Application Discontinuation
- 2006-01-27 PE PE2006000113A patent/PE20061201A1/es not_active Application Discontinuation
- 2006-01-27 JP JP2007553395A patent/JP2008528638A/ja not_active Withdrawn
- 2006-01-27 US US11/342,252 patent/US20060210557A1/en not_active Abandoned
- 2006-01-27 KR KR1020077019697A patent/KR20070107079A/ko not_active Application Discontinuation
- 2006-01-27 AR ARP060100314A patent/AR052469A1/es not_active Application Discontinuation
- 2006-01-27 BR BRPI0606867-7A patent/BRPI0606867A2/pt not_active IP Right Cessation
- 2006-01-27 AU AU2006207901A patent/AU2006207901A1/en not_active Abandoned
- 2006-01-27 TW TW095103327A patent/TW200638943A/zh unknown
- 2006-01-27 RU RU2007124933/13A patent/RU2007124933A/ru not_active Application Discontinuation
- 2006-01-27 CN CNA200680003387XA patent/CN101111264A/zh active Pending
-
2007
- 2007-07-02 IL IL184341A patent/IL184341A0/en unknown
- 2007-07-17 NO NO20073666A patent/NO20073666L/no not_active Application Discontinuation
- 2007-07-27 ZA ZA2007/06256A patent/ZA200706256B/en unknown
- 2007-08-07 CR CR9294A patent/CR9294A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PA8661401A1 (es) | 2006-09-08 |
| CN101111264A (zh) | 2008-01-23 |
| AU2006207901A1 (en) | 2006-08-03 |
| CA2595380A1 (en) | 2006-08-03 |
| WO2006081587A2 (en) | 2006-08-03 |
| TW200638943A (en) | 2006-11-16 |
| US20060210557A1 (en) | 2006-09-21 |
| JP2008528638A (ja) | 2008-07-31 |
| SV2008002394A (es) | 2008-02-08 |
| DOP2006000022A (es) | 2006-08-15 |
| MX2007009091A (es) | 2008-01-11 |
| IL184341A0 (en) | 2007-10-31 |
| PE20061201A1 (es) | 2006-11-03 |
| CR9294A (es) | 2008-01-21 |
| AR052469A1 (es) | 2007-03-21 |
| UY29350A1 (es) | 2006-08-31 |
| WO2006081587A3 (en) | 2006-10-12 |
| EP1841456A2 (de) | 2007-10-10 |
| BRPI0606867A2 (pt) | 2009-07-21 |
| RU2007124933A (ru) | 2009-03-10 |
| KR20070107079A (ko) | 2007-11-06 |
| ZA200706256B (en) | 2009-12-30 |
| GT200600033A (es) | 2006-10-25 |
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