ATE475408T1 - Formulierungen von tipifarnib zur intravenösen verabreichung - Google Patents
Formulierungen von tipifarnib zur intravenösen verabreichungInfo
- Publication number
- ATE475408T1 ATE475408T1 AT06850463T AT06850463T ATE475408T1 AT E475408 T1 ATE475408 T1 AT E475408T1 AT 06850463 T AT06850463 T AT 06850463T AT 06850463 T AT06850463 T AT 06850463T AT E475408 T1 ATE475408 T1 AT E475408T1
- Authority
- AT
- Austria
- Prior art keywords
- formulations
- tipifarnib
- intravenous administration
- intravenous
- administration
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000001990 intravenous administration Methods 0.000 title abstract 3
- PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 title abstract 2
- 229950009158 tipifarnib Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72691105P | 2005-10-14 | 2005-10-14 | |
| PCT/IB2006/004228 WO2007110709A2 (en) | 2005-10-14 | 2006-10-13 | Formulations of tipifarnib for intravenous administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE475408T1 true ATE475408T1 (de) | 2010-08-15 |
Family
ID=38541487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06850463T ATE475408T1 (de) | 2005-10-14 | 2006-10-13 | Formulierungen von tipifarnib zur intravenösen verabreichung |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070093449A1 (de) |
| EP (1) | EP1945182B1 (de) |
| JP (1) | JP5225092B2 (de) |
| CN (2) | CN106176584A (de) |
| AT (1) | ATE475408T1 (de) |
| AU (1) | AU2006341131A1 (de) |
| DE (1) | DE602006015837D1 (de) |
| ES (1) | ES2347283T3 (de) |
| WO (1) | WO2007110709A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| AU2009313927A1 (en) | 2008-11-13 | 2010-05-20 | Astrazeneca Ab | Azaquinolinone derivatives and uses thereof |
| EP2238973A1 (de) * | 2009-04-07 | 2010-10-13 | Cephalon France | Lyophilisierte Präparate von Proteasominhibitoren |
| HUE049620T2 (hu) | 2015-08-17 | 2020-09-28 | Kura Oncology Inc | Módszerek rákos páciensek kezelésére farneziltranszferáz inhibitorokkal |
| PT3534885T (pt) | 2016-11-03 | 2021-04-13 | Kura Oncology Inc | Inibidores de farnesiltransferase para usar em métodos de tratamento do cancro |
| WO2018103027A1 (zh) | 2016-12-08 | 2018-06-14 | 杭州领业医药科技有限公司 | 替吡法尼的晶型及其制备方法及药物组合物 |
| EP3432883B1 (de) * | 2017-02-21 | 2021-07-28 | Kura Oncology, Inc. | Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren |
| US10137121B2 (en) | 2017-02-21 | 2018-11-27 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| US6346518B1 (en) * | 1993-03-10 | 2002-02-12 | Janssen Pharmaceutica N.V. | Itraconazole and saperconazole stereoisomers |
| US5484798A (en) * | 1994-09-20 | 1996-01-16 | Eli Lilly And Company | Benzothiopene compounds, compositions, and method of inhibiting restenosis |
| ATE321757T1 (de) * | 1995-12-08 | 2006-04-15 | Janssen Pharmaceutica Nv | (imidazol-5-yl)methyl-2-chinolinonderivate als farnesyl protein transferase inhibitoren |
| GB9804885D0 (en) * | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| WO2002028409A2 (en) * | 2000-10-05 | 2002-04-11 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
| JP2003321364A (ja) * | 2002-05-07 | 2003-11-11 | Eisai Co Ltd | シクロデキストリンにより可溶化及び安定化された抗腫瘍剤含有組成物 |
| PE20050928A1 (es) * | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
| US7084247B2 (en) * | 2004-03-11 | 2006-08-01 | Peptimmune, Inc. | Identification of self and non-self antigens implicated in autoimmune diseases |
| EP1853265B1 (de) * | 2005-01-28 | 2016-01-27 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Farnesyltransferasehemmer zur behandlung von laminopathien, zellalterung und atherosklerose |
-
2006
- 2006-10-13 US US11/549,188 patent/US20070093449A1/en not_active Abandoned
- 2006-10-13 WO PCT/IB2006/004228 patent/WO2007110709A2/en not_active Ceased
- 2006-10-13 EP EP06850463A patent/EP1945182B1/de active Active
- 2006-10-13 AU AU2006341131A patent/AU2006341131A1/en not_active Abandoned
- 2006-10-13 CN CN201610509108.2A patent/CN106176584A/zh active Pending
- 2006-10-13 DE DE602006015837T patent/DE602006015837D1/de active Active
- 2006-10-13 JP JP2008535138A patent/JP5225092B2/ja active Active
- 2006-10-13 AT AT06850463T patent/ATE475408T1/de not_active IP Right Cessation
- 2006-10-13 ES ES06850463T patent/ES2347283T3/es active Active
- 2006-10-13 CN CNA2006800382635A patent/CN101389312A/zh active Pending
-
2008
- 2008-10-17 US US12/253,799 patent/US20090042935A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN106176584A (zh) | 2016-12-07 |
| EP1945182B1 (de) | 2010-07-28 |
| JP2009511569A (ja) | 2009-03-19 |
| US20070093449A1 (en) | 2007-04-26 |
| US20090042935A1 (en) | 2009-02-12 |
| ES2347283T3 (es) | 2010-10-27 |
| WO2007110709A8 (en) | 2008-06-19 |
| AU2006341131A1 (en) | 2007-10-04 |
| WO2007110709A2 (en) | 2007-10-04 |
| JP5225092B2 (ja) | 2013-07-03 |
| DE602006015837D1 (de) | 2010-09-09 |
| WO2007110709A3 (en) | 2008-05-08 |
| EP1945182A2 (de) | 2008-07-23 |
| CN101389312A (zh) | 2009-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2009000349A1 (es) | Compuestos derivados de 4,5-dihidro-oxazol-2-ilamina; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer. | |
| EA200901166A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr 119 | |
| MX2009000285A (es) | Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas. | |
| EA200802166A1 (ru) | Стабильная фармацевтическая композиция с защитным действием от раздражения (варианты), способ ее получения и способ лечения кальций-миметиком с ее помощью | |
| HUS1700012I1 (hu) | Bruton-tirozinkináz inhibitorok | |
| MX389697B (es) | Nuevos derivados de pirazolopirimidina. | |
| MX2009004862A (es) | Estabilizacion de vacunas por liofilizacion. | |
| CY1118731T1 (el) | Φαρμακευτικες συνθεσεις αλβιγλουτιδης | |
| ECSP10010548A (es) | Composiciones y metodos de preparacion y uso de las mismas | |
| MY143795A (en) | Tetrahydropyridoindole derivatives | |
| AR063628A1 (es) | Compuestos de piridinona utiles para el tratamiento de cancer | |
| ECSP045191A (es) | "nuevos péptidos como inhibidores de la proteasa serina ns3 del virus de la hepatitis c" | |
| MX2007002398A (es) | Nuevas composiciones farmaceuticas para el tratamiento de cancer. | |
| CL2008001721A1 (es) | Compuestos derivados de 17-beta-ciano-18 alfa-homo-19-nor-androst-4-eno; que presentan actividad gestagena y antimineralcorticoide; composicion farmaceutica; y uso en el tratamiento de trastornos pre-peri-y posmenopausicos y trastornos premenstruales. | |
| ATE548034T1 (de) | Pharmazeutische zusammensetzungen mit droxidopa | |
| SA523440384B1 (ar) | مركبات الفوسفوليبيدات واستخداماتها | |
| ATE470443T1 (de) | Indol-1-yl-essigsäurederivate | |
| UA88463C2 (ru) | Фармацевтическая композиция, которая содержит соединение 1, и процесс лечения вич-инфекции | |
| CL2008000021A1 (es) | Compuestos derivados de 2,4-dianilinopirimidinas, inhibidores de proteinas cinasas; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades inflamatorias, diabetes y cancer. | |
| EP4327874A3 (de) | 3,6-disubstituierte xanthyliumsalze | |
| CL2008003659A1 (es) | Compuestos derivados de 6-(4-bencilpiperazin-1-il)pirimidin-4-ona, moduladores de la enzima estearoil-coa-desaturasa 1; procedimiento de preparacion; composicin farmaceutica; y uso en el tratamiento y profilaxis de la obesidad. | |
| WO2008079270A3 (en) | Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis | |
| MX2008015775A (es) | Compuestos y composiciones para tratamiento de cancer. | |
| TW200738659A (en) | Novel compounds | |
| WO2007067519A3 (en) | The use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |