NO20070466L - Pyrrolopyrimidin og pyrrolopyridinderivater substituert med en cyklisk aminogruppe som CRF antagonister - Google Patents
Pyrrolopyrimidin og pyrrolopyridinderivater substituert med en cyklisk aminogruppe som CRF antagonisterInfo
- Publication number
- NO20070466L NO20070466L NO20070466A NO20070466A NO20070466L NO 20070466 L NO20070466 L NO 20070466L NO 20070466 A NO20070466 A NO 20070466A NO 20070466 A NO20070466 A NO 20070466A NO 20070466 L NO20070466 L NO 20070466L
- Authority
- NO
- Norway
- Prior art keywords
- crf
- receptors
- pyrrolopyrimidine
- amino group
- cyclic amino
- Prior art date
Links
- XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical group C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 title abstract 2
- KDOPAZIWBAHVJB-UHFFFAOYSA-N 5h-pyrrolo[3,2-d]pyrimidine Chemical group C1=NC=C2NC=CC2=N1 KDOPAZIWBAHVJB-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003277 amino group Chemical group 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 125000004122 cyclic group Chemical group 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 2
- 206010008118 cerebral infarction Diseases 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010048962 Brain oedema Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000006752 brain edema Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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-
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004188128A JP2007161585A (ja) | 2004-06-25 | 2004-06-25 | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
| PCT/JP2005/012152 WO2006001511A1 (fr) | 2004-06-25 | 2005-06-24 | Dérivés de pyrrolopyrimidine et de pyrrolopyridine substitués par un groupe amino cyclique servant d'antagonistes du crf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20070466L true NO20070466L (no) | 2007-03-20 |
Family
ID=34971526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20070466A NO20070466L (no) | 2004-06-25 | 2007-01-24 | Pyrrolopyrimidin og pyrrolopyridinderivater substituert med en cyklisk aminogruppe som CRF antagonister |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7951811B2 (fr) |
| EP (2) | EP1758903A1 (fr) |
| JP (2) | JP2007161585A (fr) |
| KR (1) | KR101290992B1 (fr) |
| CN (2) | CN101696208B (fr) |
| AU (2) | AU2005257496B2 (fr) |
| BR (1) | BRPI0512418A (fr) |
| CA (1) | CA2568804C (fr) |
| HK (2) | HK1103724A1 (fr) |
| IL (1) | IL179606A (fr) |
| MX (1) | MXPA06014990A (fr) |
| NO (1) | NO20070466L (fr) |
| NZ (2) | NZ580117A (fr) |
| RU (1) | RU2385321C2 (fr) |
| UA (1) | UA89192C2 (fr) |
| WO (1) | WO2006001511A1 (fr) |
| ZA (1) | ZA200610039B (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2552503C (fr) | 2004-01-06 | 2011-09-13 | Taisho Pharmaceutical Co., Ltd. | Derives de pyrrolopyrimidine et de pyrrolotriazine |
| WO2005066182A1 (fr) | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Derives de thienopyrimidine et de thienopyridine substitues par un groupe amino cyclique |
| RU2006128600A (ru) | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | ПРОИЗВОДНЫЕ ТРИАЗАЦИКЛОПЕНТА [cd] ИНДЕНА |
| JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
| DE102004042607A1 (de) * | 2004-09-03 | 2006-03-09 | Bayer Healthcare Ag | Substituierte Phenylaminothiazole und ihre Verwendung |
| DE102006042143A1 (de) * | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006056739A1 (de) * | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056740A1 (de) * | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| WO2009008552A1 (fr) * | 2007-07-11 | 2009-01-15 | Taisho Pharmaceutical Co., Ltd. | Dérivés de 8-aryl-4-alkylpyrrolo[2,3,4-dé]quinoléine-5(4h)-one et de 8-aryl-4-alkyl-4,5-dihydropyrrolo[2,3,4-dé]quinoléine-5-ol |
| GB0713602D0 (en) * | 2007-07-12 | 2007-08-22 | Syngenta Participations Ag | Chemical compounds |
| DE102007035367A1 (de) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102007061764A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellierte Cyanopyridine und ihre Verwendung |
| DE102007061763A1 (de) | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituierte azabicyclische Verbindungen und ihre Verwendung |
| DE102008013587A1 (de) * | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| CL2009001152A1 (es) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
| WO2009143992A1 (fr) * | 2008-05-29 | 2009-12-03 | Bayer Schering Pharma Aktiengesellschaft | Dicyanopyridines substituées par du 2-alcoxy et leur utilisation |
| CA2736018C (fr) * | 2008-09-16 | 2015-11-03 | Stephanie Merchant | Compositions pour traiter et retarder le debut de chute de cheveux |
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| US20120058983A1 (en) | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| US9732083B2 (en) | 2011-03-15 | 2017-08-15 | Merck Sharp & Dohme Corp. | Tricyclic gyrase inhibitors |
| WO2019198692A1 (fr) * | 2018-04-09 | 2019-10-17 | Raqualia Pharma Inc. | Dérivés d'urée cyclique fusionnés utilisés comme antagonistes de crhr2 |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
| CN111320634A (zh) * | 2020-04-14 | 2020-06-23 | 浙江工业大学 | 一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法 |
| CA3200318A1 (fr) * | 2020-10-30 | 2022-05-05 | 1Cbio, Inc. | Inhibiteurs d'ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) et leurs utilisations |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE177101T1 (de) * | 1992-12-17 | 1999-03-15 | Pfizer | Pyrrolopyrimidine als crf antagonisten |
| PT882051E (pt) | 1996-02-07 | 2002-04-29 | Janssen Pharmaceutica Nv | Tiofenopirimidinas |
| KR20010005568A (ko) | 1997-03-26 | 2001-01-15 | 우에하라 아끼라 | 4-테트라히드로피리딜피리미딘 유도체 |
| CA2272292A1 (fr) | 1997-04-22 | 1998-10-29 | Janssen Pharmaceutica N.V. | Thiophenopyridines antagonistes du crf |
| EP1068207A1 (fr) | 1998-04-02 | 2001-01-17 | Neurogen Corporation | DERIVES AMINOALKYLE SUBSTITUES DE 9H-PYRIDINO 2,3-b]INDOLE ET 9H-PYRIMIDINO 4,5-b]INDOLE |
| WO1999051599A1 (fr) * | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Derives aminoalkyle substitues de pyrrolo[2,3-b]pyridine et pyrrolo[2,3-d]pyrimidine: modulateurs de recepteurs de crf1 |
| AU3375999A (en) * | 1998-04-02 | 1999-10-25 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino(2,3-b)indole and 5,6,7,8-tetrahydro-9h-pyrimidino(4,5-b)indole derivatives: crf1 specific ligands |
| EP1176146B1 (fr) * | 1999-03-11 | 2005-06-08 | Taisho Pharmaceutical Co., Ltd | Derives de carbamoyl tetrahydropyridine |
| AR028782A1 (es) * | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
| TWI270549B (en) * | 2002-12-26 | 2007-01-11 | Taisho Pharmaceutical Co Ltd | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group |
| WO2005066182A1 (fr) | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Derives de thienopyrimidine et de thienopyridine substitues par un groupe amino cyclique |
| RU2006128600A (ru) * | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | ПРОИЗВОДНЫЕ ТРИАЗАЦИКЛОПЕНТА [cd] ИНДЕНА |
| CA2552503C (fr) | 2004-01-06 | 2011-09-13 | Taisho Pharmaceutical Co., Ltd. | Derives de pyrrolopyrimidine et de pyrrolotriazine |
| EP1725562A1 (fr) | 2004-03-05 | 2006-11-29 | Taisho Pharmaceutical Co., Ltd | D riv s pyrrolopyrimidine |
| WO2006001501A1 (fr) | 2004-06-25 | 2006-01-05 | Taisho Pharmaceutical Co., Ltd. | Dérivés de pyrrolopyrimidine et de pyrrolopyridine substitués avec de la tétrahydropyridine comme antagonistes du crf |
| JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
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2004
- 2004-06-25 JP JP2004188128A patent/JP2007161585A/ja active Pending
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2005
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- 2005-06-24 ZA ZA200610039A patent/ZA200610039B/xx unknown
- 2005-06-24 MX MXPA06014990A patent/MXPA06014990A/es active IP Right Grant
- 2005-06-24 KR KR1020067027082A patent/KR101290992B1/ko not_active IP Right Cessation
- 2005-06-24 EP EP05755742A patent/EP1758903A1/fr not_active Ceased
- 2005-06-24 CN CN2009101776790A patent/CN101696208B/zh not_active Expired - Fee Related
- 2005-06-24 RU RU2007102699/04A patent/RU2385321C2/ru not_active IP Right Cessation
- 2005-06-24 EP EP08002525A patent/EP1953160A1/fr not_active Withdrawn
- 2005-06-24 CN CN2005800209622A patent/CN1972940B/zh not_active Expired - Fee Related
- 2005-06-24 NZ NZ580117A patent/NZ580117A/en not_active IP Right Cessation
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- 2005-06-24 AU AU2005257496A patent/AU2005257496B2/en not_active Ceased
- 2005-06-24 WO PCT/JP2005/012152 patent/WO2006001511A1/fr active Application Filing
- 2005-06-24 CA CA2568804A patent/CA2568804C/fr not_active Expired - Fee Related
- 2005-06-24 BR BRPI0512418-2A patent/BRPI0512418A/pt not_active IP Right Cessation
- 2005-06-24 UA UAA200700786A patent/UA89192C2/ru unknown
- 2005-06-24 NZ NZ551427A patent/NZ551427A/en not_active IP Right Cessation
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2006
- 2006-11-27 IL IL179606A patent/IL179606A/en not_active IP Right Cessation
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2007
- 2007-01-24 NO NO20070466A patent/NO20070466L/no not_active Application Discontinuation
- 2007-07-24 HK HK07107984.6A patent/HK1103724A1/xx not_active IP Right Cessation
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2010
- 2010-06-07 HK HK10105586.7A patent/HK1139655A1/xx not_active IP Right Cessation
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2011
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- 2011-02-03 AU AU2011200450A patent/AU2011200450B2/en not_active Ceased
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