NO20070467L - Pyrrolopyrimidin og pyrrolopyridinderivater substituert med tetrahydropyridin som CRF antagonister - Google Patents

Pyrrolopyrimidin og pyrrolopyridinderivater substituert med tetrahydropyridin som CRF antagonister

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Publication number
NO20070467L
NO20070467L NO20070467A NO20070467A NO20070467L NO 20070467 L NO20070467 L NO 20070467L NO 20070467 A NO20070467 A NO 20070467A NO 20070467 A NO20070467 A NO 20070467A NO 20070467 L NO20070467 L NO 20070467L
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NO
Norway
Prior art keywords
crf
pyrrolopyrimidine
tetrahydropyridine
diseases
derivatives substituted
Prior art date
Application number
NO20070467A
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Marcel Frans Leopold De Bruyn
Atsuro Nakazato
Taketoshi Okubo
Dai Nozawa
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Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of NO20070467L publication Critical patent/NO20070467L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår en antagonist overfor CRF-reseptorer som er effektiv som et terapeutisk eller profylaktisk middel for sykdommer hvor CRF anses å være involvert, slik som depresjon, angst, Alzheimers sykdom, Parkinsons sykdom, Huntingtons chorea, spiseforstyrrelser, hypertensjon, gastrointestinale sykdommer, legemiddelavhengighet, cerebralt infarkt, cerebralt iskemi, cerebralt ødem, kefalisk eksternt sår, inflammasjon, immunrelaterte sykdommer, alopeci, irritabelt tarmsyndrom, søvnforstyrrelser, epilepsi, dermatitt, schizofreni, smerter etc. Et pyrrolopyrimidin eller pyrrolopyridin-derivat substituert med tetrahydropyridin representert ved formel [I] har en høy affinitet for CRF-reseptorer og er effektiv overfor sykdommer hvori CRF anses å være involvert.
NO20070467A 2004-06-25 2007-01-24 Pyrrolopyrimidin og pyrrolopyridinderivater substituert med tetrahydropyridin som CRF antagonister NO20070467L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004188129 2004-06-25
PCT/JP2005/012141 WO2006001501A1 (en) 2004-06-25 2005-06-24 Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with tetrahydropyridine as crf antagonists

Publications (1)

Publication Number Publication Date
NO20070467L true NO20070467L (no) 2007-01-24

Family

ID=34971524

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070467A NO20070467L (no) 2004-06-25 2007-01-24 Pyrrolopyrimidin og pyrrolopyridinderivater substituert med tetrahydropyridin som CRF antagonister

Country Status (14)

Country Link
US (1) US20070293670A1 (no)
EP (1) EP1781652A1 (no)
JP (1) JP2008503443A (no)
KR (1) KR20070024632A (no)
CN (1) CN1972941A (no)
AU (1) AU2005257486A1 (no)
BR (1) BRPI0512514A (no)
CA (1) CA2568802A1 (no)
IL (1) IL179605A0 (no)
MX (1) MXPA06015002A (no)
NO (1) NO20070467L (no)
RU (1) RU2007102683A (no)
WO (1) WO2006001501A1 (no)
ZA (1) ZA200610043B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005066182A1 (en) 2004-01-06 2005-07-21 Taisho Pharmaceutical Co., Ltd. Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group
CA2552503C (en) 2004-01-06 2011-09-13 Taisho Pharmaceutical Co., Ltd. Pyrrolopyrimidine and pyrrolotriazine derivatives
RU2006128600A (ru) 2004-01-06 2008-02-20 Тайсо Фармасьютикал Ко., Лтд. (Jp) ПРОИЗВОДНЫЕ ТРИАЗАЦИКЛОПЕНТА [cd] ИНДЕНА
JP2007161585A (ja) 2004-06-25 2007-06-28 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
DE102006042143A1 (de) * 2006-09-08 2008-03-27 Bayer Healthcare Aktiengesellschaft Neue substituierte Bipyridin-Derivate und ihre Verwendung
DE102006056739A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung
DE102006056740A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
US7738257B2 (en) * 2006-12-13 2010-06-15 Intel Corporation Microelectronic device including bridging interconnect to top conductive layer of passive embedded structure and method of making same
DE102007035367A1 (de) 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituierte Aryloxazole und ihre Verwendung
DE102007036076A1 (de) 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
DE102007061764A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellierte Cyanopyridine und ihre Verwendung
DE102007061763A1 (de) 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
DE102008013587A1 (de) * 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
WO2009143992A1 (de) * 2008-05-29 2009-12-03 Bayer Schering Pharma Aktiengesellschaft 2-alkoxy-substituierte dicyanopyridine und ihre verwendung
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension

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US2941454A (en) * 1957-10-21 1960-06-21 Cedeno Arturo Olivero Traffic intersection
US3945745A (en) * 1974-08-05 1976-03-23 Chang Amos I T Traffic flow control systems
KR20010005568A (ko) * 1997-03-26 2001-01-15 우에하라 아끼라 4-테트라히드로피리딜피리미딘 유도체
EP1176146B1 (en) * 1999-03-11 2005-06-08 Taisho Pharmaceutical Co., Ltd Carbamoyl tetrahydropyridine derivatives
AR028782A1 (es) * 2000-07-05 2003-05-21 Taisho Pharmaceutical Co Ltd Derivados heterociclicos tetrahidropiridino o piperidino
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TWI270549B (en) * 2002-12-26 2007-01-11 Taisho Pharmaceutical Co Ltd Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
RU2006128600A (ru) * 2004-01-06 2008-02-20 Тайсо Фармасьютикал Ко., Лтд. (Jp) ПРОИЗВОДНЫЕ ТРИАЗАЦИКЛОПЕНТА [cd] ИНДЕНА
WO2005066182A1 (en) * 2004-01-06 2005-07-21 Taisho Pharmaceutical Co., Ltd. Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group

Also Published As

Publication number Publication date
WO2006001501A1 (en) 2006-01-05
IL179605A0 (en) 2007-05-15
AU2005257486A1 (en) 2006-01-05
BRPI0512514A (pt) 2008-03-11
JP2008503443A (ja) 2008-02-07
MXPA06015002A (es) 2007-02-08
CN1972941A (zh) 2007-05-30
RU2007102683A (ru) 2008-07-27
ZA200610043B (en) 2008-06-25
US20070293670A1 (en) 2007-12-20
EP1781652A1 (en) 2007-05-09
KR20070024632A (ko) 2007-03-02
CA2568802A1 (en) 2006-01-05

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