NO20070455L - Nye arylamidinderivater, salter derav og soppmidler inneholdende slike - Google Patents

Nye arylamidinderivater, salter derav og soppmidler inneholdende slike

Info

Publication number
NO20070455L
NO20070455L NO20070455A NO20070455A NO20070455L NO 20070455 L NO20070455 L NO 20070455L NO 20070455 A NO20070455 A NO 20070455A NO 20070455 A NO20070455 A NO 20070455A NO 20070455 L NO20070455 L NO 20070455L
Authority
NO
Norway
Prior art keywords
salts
new
derivative
salt
arylamidine
Prior art date
Application number
NO20070455A
Other languages
English (en)
Other versions
NO339158B1 (no
Inventor
Kazuya Hayashi
Kazuto Kunitani
Sayuri Uehara
Teiichi Morita
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of NO20070455L publication Critical patent/NO20070455L/no
Publication of NO339158B1 publication Critical patent/NO339158B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Et arylamidin-derivat representert ved den generelle formel (hvor R1 representerer eventuelt beskyttet eller substituert amidino; og R2 og R3 er like eller forskjellige og hver representerer hydrogen eller halogen), eller et salt av derivatet. Derivatet og saltet har kraftig aktivitet overfor sopp, omfattende dem som har toleranse overfor azol-typen av medikamenter, og har videre høy sikkerhet og utmerkede egenskaper i en toksisitetstest med gjentatt dose. De er således anvendelige som et utmerket anti-soppmiddel.
NO20070455A 2004-06-30 2007-01-24 Salt av arylamidin-derivat og anti-soppmiddel inneholdende dette NO339158B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004193386 2004-06-30
PCT/JP2005/011809 WO2006003881A1 (ja) 2004-06-30 2005-06-28 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤

Publications (2)

Publication Number Publication Date
NO20070455L true NO20070455L (no) 2007-01-24
NO339158B1 NO339158B1 (no) 2016-11-14

Family

ID=35782688

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070455A NO339158B1 (no) 2004-06-30 2007-01-24 Salt av arylamidin-derivat og anti-soppmiddel inneholdende dette

Country Status (20)

Country Link
US (1) US7700623B2 (no)
EP (1) EP1767526B1 (no)
JP (1) JP4885722B2 (no)
KR (1) KR101169694B1 (no)
CN (1) CN100567267C (no)
AU (1) AU2005258613B2 (no)
BR (1) BRPI0512661B8 (no)
CA (1) CA2572161C (no)
CY (1) CY1113266T1 (no)
DK (1) DK1767526T3 (no)
ES (1) ES2393924T3 (no)
IL (1) IL180192A (no)
NO (1) NO339158B1 (no)
NZ (1) NZ552184A (no)
PL (1) PL1767526T3 (no)
PT (1) PT1767526E (no)
RU (1) RU2359959C2 (no)
SI (1) SI1767526T1 (no)
WO (1) WO2006003881A1 (no)
ZA (1) ZA200700806B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200708530B (en) * 2005-04-07 2009-04-29 Toyama Chemical Co Ltd Pharmaceutical composition and method using antifungal agent in combination
BRPI0613505A2 (pt) * 2005-06-30 2011-01-11 Prosidion Ltd agonistas de gpcr
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
CA2634846C (en) * 2005-12-29 2013-02-19 Toyama Chemical Co., Ltd. Novel arylamidine derivative, salt thereof and antifungal agent containing those
BRPI0719157A2 (pt) * 2006-10-06 2014-02-04 Toyama Chemical Co Ltd Composição farmacêutica para o tratamento de infecções fúngicas, e, método de uso combinado para o tratamento de infecções fúngicas causadas por patógenos fúngicos.
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
TWI395735B (zh) * 2007-07-04 2013-05-11 Toyama Chemical Co Ltd ４－｛３－〔４－（３－｛４－〔胺基（丁氧基羰基亞胺基）甲基〕苯氧基｝丙基）－１－哌啶基〕丙氧基｝－ｎ’－（丁氧基羰基）苄脒之新穎結晶
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
AU2014200451B2 (en) * 2008-02-01 2016-03-03 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Use of amidoxime carboxylic acid esters and n-hydroxyguanidine carboxylic acid esters for producing prodrugs
US9662308B2 (en) * 2008-02-01 2017-05-30 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Orally bioavailable pentamidine prodrugs for the treatment of diseases
DE102008007381A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten
WO2011104540A1 (en) * 2010-02-24 2011-09-01 Generics [Uk] Limited One step process for the preparation of capecitabine
EP2623102B1 (en) * 2010-09-30 2019-01-09 FUJIFILM Toyama Chemical Co., Ltd. Transdermal absorption preparation
EP2636409A1 (en) 2010-11-05 2013-09-11 Eisai R&D Management Co., Ltd. Combined pharmaceutical composition as antifungal agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4320260B2 (ja) * 2002-03-06 2009-08-26 富山化学工業株式会社 新規なアリールアミジン誘導体またはその塩

Also Published As

Publication number Publication date
IL180192A (en) 2011-01-31
CY1113266T1 (el) 2016-04-13
BRPI0512661B8 (pt) 2021-05-25
NZ552184A (en) 2009-11-27
RU2359959C2 (ru) 2009-06-27
KR101169694B1 (ko) 2012-07-31
NO339158B1 (no) 2016-11-14
EP1767526A1 (en) 2007-03-28
IL180192A0 (en) 2007-06-03
ES2393924T3 (es) 2013-01-02
AU2005258613B2 (en) 2011-03-17
EP1767526A4 (en) 2009-05-06
WO2006003881A1 (ja) 2006-01-12
EP1767526B1 (en) 2012-10-24
US20080319016A1 (en) 2008-12-25
AU2005258613A1 (en) 2006-01-12
CN100567267C (zh) 2009-12-09
PL1767526T3 (pl) 2013-03-29
CA2572161C (en) 2012-10-02
JPWO2006003881A1 (ja) 2008-04-17
DK1767526T3 (da) 2012-11-12
BRPI0512661B1 (pt) 2020-10-27
ZA200700806B (en) 2008-12-31
CA2572161A1 (en) 2006-01-12
CN1976901A (zh) 2007-06-06
BRPI0512661A (pt) 2008-04-01
SI1767526T1 (sl) 2013-02-28
RU2007103176A (ru) 2008-08-10
PT1767526E (pt) 2012-12-10
JP4885722B2 (ja) 2012-02-29
KR20070030305A (ko) 2007-03-15
US7700623B2 (en) 2010-04-20

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: FUJIFILM TOYAMA CHEMICAL CO., JP

CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: APPILI THERAPEUTICS INC., CA