CY1113266T1 - Παραγωγο αρυλαμιδινης, αλας αυτου και αντιμυκητιασικο περιεχον αυτα - Google Patents

Παραγωγο αρυλαμιδινης, αλας αυτου και αντιμυκητιασικο περιεχον αυτα

Info

Publication number
CY1113266T1
CY1113266T1 CY20121101031T CY121101031T CY1113266T1 CY 1113266 T1 CY1113266 T1 CY 1113266T1 CY 20121101031 T CY20121101031 T CY 20121101031T CY 121101031 T CY121101031 T CY 121101031T CY 1113266 T1 CY1113266 T1 CY 1113266T1
Authority
CY
Cyprus
Prior art keywords
derivative
arylamidin
silver
production
salt
Prior art date
Application number
CY20121101031T
Other languages
English (en)
Inventor
Kazuya Hayashi
Kazuto Kunitani
Sayuri Uehara
Teiichi Morita
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1113266T1 publication Critical patent/CY1113266T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Ένα παράγωγο αρυλαμιδίνης που παριστάνεται με το γενικό τύπο (όπου το R1 παριστάνει προαιρετικώς προστατευμένη ή υποκατεστημένη αμιδινο· και τα R2 και R3 είναι τα ίδια ή διαφορετικά και το καθένα παριστάνει υδρογόνο ή αλογόνο) ή ένα άλας του παραγώγου. Το παράγωγο και το άλας έχουν ισχυρή δραστικότητα κατά μυκήτων συμπεριλαμβανόμενων αυτών που έχουν ανοχή σε φάρμακα τύπου αζόλης και περαιτέρω έχουν υψηλή ασφάλεια και εξαιρετικές ιδιότητες σε μια δοκιμασία τοξικότητας με επαναλαμβανόμενη δόση. Συνεπώς είναι χρήσιμα ως ένα εξαιρετικό αντιμυκητιασικό.
CY20121101031T 2004-06-30 2012-10-30 Παραγωγο αρυλαμιδινης, αλας αυτου και αντιμυκητιασικο περιεχον αυτα CY1113266T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004193386 2004-06-30
EP05765373A EP1767526B1 (en) 2004-06-30 2005-06-28 Arylamidine derivative, salt thereof and antifungal containing these

Publications (1)

Publication Number Publication Date
CY1113266T1 true CY1113266T1 (el) 2016-04-13

Family

ID=35782688

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101031T CY1113266T1 (el) 2004-06-30 2012-10-30 Παραγωγο αρυλαμιδινης, αλας αυτου και αντιμυκητιασικο περιεχον αυτα

Country Status (20)

Country Link
US (1) US7700623B2 (el)
EP (1) EP1767526B1 (el)
JP (1) JP4885722B2 (el)
KR (1) KR101169694B1 (el)
CN (1) CN100567267C (el)
AU (1) AU2005258613B2 (el)
BR (1) BRPI0512661B8 (el)
CA (1) CA2572161C (el)
CY (1) CY1113266T1 (el)
DK (1) DK1767526T3 (el)
ES (1) ES2393924T3 (el)
IL (1) IL180192A (el)
NO (1) NO339158B1 (el)
NZ (1) NZ552184A (el)
PL (1) PL1767526T3 (el)
PT (1) PT1767526E (el)
RU (1) RU2359959C2 (el)
SI (1) SI1767526T1 (el)
WO (1) WO2006003881A1 (el)
ZA (1) ZA200700806B (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1867332B1 (en) * 2005-04-07 2011-08-24 Toyama Chemical Co., Ltd. Pharmaceutical composition and method using antifungal agent in combination
CA2613235A1 (en) * 2005-06-30 2007-01-11 Prosidion Limited Gpcr agonists
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
US8536343B2 (en) * 2005-12-29 2013-09-17 Toyama Chemical Co., Ltd. Arylamidine derivative, salt thereof and antifungal agent containing those
AU2007305626B2 (en) 2006-10-06 2013-01-10 Toyama Chemical Co., Ltd. Pharmaceutical composition comprising phenylamidine derivative and method of using the pharmaceutical composition in combination with antifungal agent
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
TWI395735B (zh) * 2007-07-04 2013-05-11 Toyama Chemical Co Ltd ４－｛３－〔４－（３－｛４－〔胺基（丁氧基羰基亞胺基）甲基〕苯氧基｝丙基）－１－哌啶基〕丙氧基｝－ｎ’－（丁氧基羰基）苄脒之新穎結晶
US9662308B2 (en) * 2008-02-01 2017-05-30 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Orally bioavailable pentamidine prodrugs for the treatment of diseases
AU2014200451B2 (en) * 2008-02-01 2016-03-03 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Use of amidoxime carboxylic acid esters and n-hydroxyguanidine carboxylic acid esters for producing prodrugs
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
DE102008007381A1 (de) 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten
WO2011104540A1 (en) * 2010-02-24 2011-09-01 Generics [Uk] Limited One step process for the preparation of capecitabine
PL2623102T3 (pl) * 2010-09-30 2019-07-31 Fujifilm Toyama Chemical Co., Ltd. Transdermalny absorbujący preparat
JPWO2012060448A1 (ja) 2010-11-05 2014-05-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗真菌剤としての併用医薬組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL163798A0 (en) * 2002-03-06 2005-12-18 Toyama Chemical Co Ltd Novel arylamidine derivative or salt thereof

Also Published As

Publication number Publication date
PL1767526T3 (pl) 2013-03-29
CN1976901A (zh) 2007-06-06
AU2005258613A1 (en) 2006-01-12
JP4885722B2 (ja) 2012-02-29
CA2572161A1 (en) 2006-01-12
JPWO2006003881A1 (ja) 2008-04-17
NO20070455L (no) 2007-01-24
RU2359959C2 (ru) 2009-06-27
DK1767526T3 (da) 2012-11-12
EP1767526A1 (en) 2007-03-28
BRPI0512661B1 (pt) 2020-10-27
AU2005258613B2 (en) 2011-03-17
US20080319016A1 (en) 2008-12-25
KR101169694B1 (ko) 2012-07-31
IL180192A0 (en) 2007-06-03
WO2006003881A1 (ja) 2006-01-12
PT1767526E (pt) 2012-12-10
EP1767526B1 (en) 2012-10-24
KR20070030305A (ko) 2007-03-15
IL180192A (en) 2011-01-31
RU2007103176A (ru) 2008-08-10
EP1767526A4 (en) 2009-05-06
BRPI0512661A (pt) 2008-04-01
NZ552184A (en) 2009-11-27
BRPI0512661B8 (pt) 2021-05-25
CA2572161C (en) 2012-10-02
NO339158B1 (no) 2016-11-14
ES2393924T3 (es) 2013-01-02
US7700623B2 (en) 2010-04-20
ZA200700806B (en) 2008-12-31
CN100567267C (zh) 2009-12-09
SI1767526T1 (sl) 2013-02-28

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