ATE443717T1 - Metastin derivate und ihre verwendung - Google Patents
Metastin derivate und ihre verwendungInfo
- Publication number
- ATE443717T1 ATE443717T1 AT04700164T AT04700164T ATE443717T1 AT E443717 T1 ATE443717 T1 AT E443717T1 AT 04700164 T AT04700164 T AT 04700164T AT 04700164 T AT04700164 T AT 04700164T AT E443717 T1 ATE443717 T1 AT E443717T1
- Authority
- AT
- Austria
- Prior art keywords
- metastin derivatives
- derivatives
- relates
- suppressing activity
- metastin
- Prior art date
Links
- KAHDONZOCXSKII-NJVVDGNHSA-N kisspeptin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C1=CN=CN1 KAHDONZOCXSKII-NJVVDGNHSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/337,105 US6800611B2 (en) | 2003-01-06 | 2003-01-06 | Metastin derivatives and their use |
| PCT/IB2004/000606 WO2004060264A2 (en) | 2003-01-06 | 2004-01-05 | Metastin derivatives and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443717T1 true ATE443717T1 (de) | 2009-10-15 |
Family
ID=32710947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04700164T ATE443717T1 (de) | 2003-01-06 | 2004-01-05 | Metastin derivate und ihre verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6800611B2 (de) |
| EP (1) | EP1581557B1 (de) |
| JP (1) | JP4335910B2 (de) |
| CN (1) | CN1756765A (de) |
| AT (1) | ATE443717T1 (de) |
| CA (1) | CA2512553A1 (de) |
| DE (1) | DE602004023271D1 (de) |
| WO (1) | WO2004060264A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003292696A1 (en) * | 2002-12-26 | 2004-08-10 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| US7754220B2 (en) | 2003-03-12 | 2010-07-13 | Takeda Pharmaceutical Company Limited | Methods of inhibiting secretion of follicle-stimulating hormone and testosterone |
| BRPI0512397A (pt) * | 2004-06-25 | 2008-03-04 | Takeda Pharmaceutical | composto,produto farmacêutico, métodos para suprimir a metástase de cáncer ou o crescimento do cáncer, para prevenir ou tratar uma doença ou condição, para controlar a função placentária, para melhorar a função gonadal, para induzir ou estimular a ovulação, para promover a secreção do hormÈnio gonadotrópico ou promover a secreção do hormÈnio sexual, para suprimir a secreção do hormÈnio gonadotrópico ou suprimir a secreção do hormÈnio sexual, para infra regular hormÈnio gonadrotópico ou hormÈnio sexual, e a proteìna ot7t175 humana, e para realçar a estabilidade no sangue, uso do composto, e, agente para suprimir a secreção do hormÈnio gonadotrópico ou um agente para suprimir a secreção do hormÈnio sexual |
| ZA200805393B (en) * | 2005-12-22 | 2009-12-30 | Takeda Pharmaceutical | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| JP5279021B2 (ja) * | 2006-04-26 | 2013-09-04 | 国立大学法人京都大学 | Ｇｐｒ５４アゴニスト活性を有する新規化合物 |
| CN101528772B (zh) * | 2006-10-25 | 2013-03-13 | 武田药品工业株式会社 | Metastin衍生物及其用途 |
| JO3048B1 (ar) * | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| GB0719592D0 (en) | 2007-10-08 | 2007-11-14 | Medical Res Council | Compound, use and method |
| EP2277900A4 (de) * | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | Metastinderivat und seine verwendung |
| US8592379B2 (en) * | 2008-04-30 | 2013-11-26 | Kyoto University | Metastin derivative and use thereof |
| HUE030900T2 (en) * | 2008-07-30 | 2017-06-28 | Takeda Pharmaceuticals Co | Metastin derivative and use thereof |
| EP2340047A1 (de) * | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymerkonjugate von kiss1-peptiden |
| AU2009292643B2 (en) | 2008-09-19 | 2016-02-18 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
| KR20110111420A (ko) * | 2008-12-29 | 2011-10-11 | 다케다 야쿠힌 고교 가부시키가이샤 | 암을 위한 예방/치료제 |
| US8716228B2 (en) | 2009-05-27 | 2014-05-06 | Yeda Research And Development Co. Ltd. | GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| US9382293B2 (en) | 2012-03-14 | 2016-07-05 | Yeda Research And Development Co. Ltd. | Modified kisspeptin peptides and uses thereof |
| HK1250902A1 (zh) * | 2015-04-23 | 2019-01-18 | Obalon Therapeutics, Inc. | 用於确定内部装置故障的系统和方法 |
| TW202334178A (zh) | 2017-07-05 | 2023-09-01 | 大陸商尚華醫藥科技（江西）有限公司 | 一種Kiss1肽類化合物、其應用及含其的組合物 |
| WO2025217074A1 (en) | 2024-04-08 | 2025-10-16 | Radionetics Oncology, Inc. | Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4486187B2 (ja) * | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド |
| US20050240008A1 (en) | 2000-03-30 | 2005-10-27 | Tetsuya Ohtaki | Novel protein, dna thereof and process for producing the same |
| WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
| AU2003292696A1 (en) * | 2002-12-26 | 2004-08-10 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
-
2003
- 2003-01-06 US US10/337,105 patent/US6800611B2/en not_active Expired - Lifetime
-
2004
- 2004-01-05 CA CA002512553A patent/CA2512553A1/en not_active Abandoned
- 2004-01-05 WO PCT/IB2004/000606 patent/WO2004060264A2/en not_active Ceased
- 2004-01-05 EP EP04700164A patent/EP1581557B1/de not_active Expired - Lifetime
- 2004-01-05 AT AT04700164T patent/ATE443717T1/de not_active IP Right Cessation
- 2004-01-05 CN CNA2004800060897A patent/CN1756765A/zh active Pending
- 2004-01-05 JP JP2006500328A patent/JP4335910B2/ja not_active Expired - Lifetime
- 2004-01-05 DE DE602004023271T patent/DE602004023271D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6800611B2 (en) | 2004-10-05 |
| WO2004060264A2 (en) | 2004-07-22 |
| WO2004060264A3 (en) | 2004-12-02 |
| DE602004023271D1 (de) | 2009-11-05 |
| CN1756765A (zh) | 2006-04-05 |
| US20040142875A1 (en) | 2004-07-22 |
| JP2006517922A (ja) | 2006-08-03 |
| JP4335910B2 (ja) | 2009-09-30 |
| EP1581557B1 (de) | 2009-09-23 |
| CA2512553A1 (en) | 2004-07-22 |
| EP1581557A2 (de) | 2005-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |