NO20070295L - Nye CIS-imidazoliner - Google Patents
Nye CIS-imidazolinerInfo
- Publication number
- NO20070295L NO20070295L NO20070295A NO20070295A NO20070295L NO 20070295 L NO20070295 L NO 20070295L NO 20070295 A NO20070295 A NO 20070295A NO 20070295 A NO20070295 A NO 20070295A NO 20070295 L NO20070295 L NO 20070295L
- Authority
- NO
- Norway
- Prior art keywords
- imidazolines
- compounds
- new cis
- cis
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse omhandler forbindelser med formel (I) og de farmasøytisk akseptable salter og estere derav, en fremgangsmåte for fremstilling av dem, medikamenter inneholdende dem så vel som anvendelsen av disse forbindelsene som farmasøytisk aktive midler. Forbindelsene viser antiproliferativ aktivitet og kan være spesielt anvendelige for behandlingen av kreft.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58044104P | 2004-06-17 | 2004-06-17 | |
US67419605P | 2005-04-22 | 2005-04-22 | |
PCT/EP2005/006167 WO2005123691A1 (en) | 2004-06-17 | 2005-06-08 | Novel cis-imidazolines |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20070295L true NO20070295L (no) | 2007-01-17 |
Family
ID=34969621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070295A NO20070295L (no) | 2004-06-17 | 2007-01-16 | Nye CIS-imidazoliner |
Country Status (16)
Country | Link |
---|---|
US (1) | US7893278B2 (no) |
EP (1) | EP1758868A1 (no) |
JP (1) | JP4809336B2 (no) |
KR (1) | KR100855929B1 (no) |
AR (1) | AR049647A1 (no) |
AU (1) | AU2005254643A1 (no) |
BR (1) | BRPI0512237A (no) |
CA (1) | CA2569598A1 (no) |
IL (1) | IL179730A0 (no) |
MX (1) | MXPA06014806A (no) |
NO (1) | NO20070295L (no) |
NZ (1) | NZ551659A (no) |
RU (1) | RU2408593C2 (no) |
SG (1) | SG148177A1 (no) |
TW (1) | TW200637828A (no) |
WO (1) | WO2005123691A1 (no) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101139263B1 (ko) | 2005-03-16 | 2012-05-16 | 에프. 호프만-라 로슈 아게 | 시스-2,4,5-트리아릴-이미다졸린 및 항암 약제로서의그의 용도 |
WO2007063013A1 (en) | 2005-12-01 | 2007-06-07 | F. Hoffmann-La Roche Ag | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents |
WO2007082805A1 (en) * | 2006-01-18 | 2007-07-26 | F. Hoffmann-La Roche Ag | Cis-4, 5-biaryl-2-heterocyclic-imidazolines as mdm2 inhibitors |
KR20090090383A (ko) | 2006-12-14 | 2009-08-25 | 다이이찌 산쿄 가부시키가이샤 | 이미다조티아졸 유도체 |
WO2008095063A1 (en) * | 2007-01-31 | 2008-08-07 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
US7625895B2 (en) | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
DE602008002592D1 (de) * | 2007-05-21 | 2010-10-28 | Lubrizol Advanced Mat Inc | Harte, aliphatische thermoplastische Polyurethane |
US9072729B2 (en) * | 2008-01-30 | 2015-07-07 | Agency For Science, Technology And Research | Method for treating fibrosis and cancer with imidazolium and imidazolinium compounds |
EP2803356A1 (en) * | 2008-03-31 | 2014-11-19 | Agency for Science, Technology and Research | Method for treating neurological disorders with imidazolium and imidazolinium compounds |
JPWO2009151069A1 (ja) | 2008-06-12 | 2011-11-17 | 第一三共株式会社 | 4,7−ジアザスピロ[2.5]オクタン環構造を有するイミダゾチアゾール誘導体 |
PT2380892E (pt) | 2009-01-16 | 2014-06-09 | Daiichi Sankyo Co Ltd | Derivado de imidazotiazole compreendendo uma estrutura de anel prolina |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
US8889863B2 (en) | 2010-07-16 | 2014-11-18 | Vanderbilt University | Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds |
SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
US9266860B2 (en) | 2010-09-30 | 2016-02-23 | St. Jude Children's Research Hospital | Aryl-substituted imidazoles |
MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
AU2012326026B2 (en) | 2011-10-18 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocyles |
CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
ES2707305T3 (es) | 2012-12-20 | 2019-04-03 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de HDM2 |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
EP2961735B1 (en) | 2013-02-28 | 2017-09-27 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
US9758495B2 (en) | 2013-03-14 | 2017-09-12 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
CN117679487A (zh) | 2013-03-15 | 2024-03-12 | 得克萨斯州大学系统董事会 | 用Nutlin-3a和肽抑制肺纤维化 |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
CN106163557B (zh) | 2014-01-28 | 2020-07-14 | 巴克老龄化研究所 | 用于杀死衰老细胞和用于治疗衰老相关疾病和病症的方法和组合物 |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 |
SG10201913290QA (en) | 2016-03-15 | 2020-03-30 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for the treatment of hematological malignancies |
AU2017233898B2 (en) | 2016-03-15 | 2022-12-15 | Oryzon Genomics, S.A. | Combinations of LSD1 inhibitors for use in the treatment of solid tumors |
EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
AU2017418538B2 (en) | 2017-06-16 | 2021-10-21 | Unity Biotechnology, Inc. | Synthesis method for producing enantiomerically pure cis-imidazoline compounds for pharmaceutical use |
US10588916B2 (en) | 2017-10-31 | 2020-03-17 | Unity Biotechnology, Inc. | Technology to inhibit vascular changes that lead to vision loss in the eye |
JP7204391B2 (ja) * | 2018-09-18 | 2023-01-16 | 株式会社東芝 | 酸性ガス吸収剤、酸性ガスの除去方法及び酸性ガス除去装置 |
KR102622992B1 (ko) * | 2021-03-29 | 2024-01-10 | 주식회사 퓨전바이오텍 | 이미다졸린 유도체 및 이의 중간체 제조방법 |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2441498A (en) * | 1943-07-15 | 1948-05-11 | Astra Apotekarnes Kem Fab | Alkyl glycinanilides |
JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
DE4203547A1 (de) * | 1992-02-07 | 1993-08-12 | Knoll Ag | Verfahren zur racemattrennung von verapamil |
GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
US6653501B2 (en) | 2001-06-27 | 2003-11-25 | Napro Biotherapeutics, Inc. | Chiral resolution method for producing compounds useful in the synthesis of taxanes |
CA2468783A1 (en) | 2001-12-18 | 2003-06-26 | F. Hoffmann-La Roche Ag | Cis-imidazolines as mdm2 inhibitors |
CN100486969C (zh) * | 2001-12-18 | 2009-05-13 | 霍夫曼-拉罗奇有限公司 | 顺式-2,4,5-三苯基-咪唑啉及其在肿瘤治疗中的应用 |
KR100832277B1 (ko) * | 2004-05-18 | 2008-05-26 | 에프. 호프만-라 로슈 아게 | 신규 cis-이미다졸린 |
-
2005
- 2005-06-02 US US11/143,161 patent/US7893278B2/en not_active Expired - Fee Related
- 2005-06-08 RU RU2007101275/04A patent/RU2408593C2/ru not_active IP Right Cessation
- 2005-06-08 WO PCT/EP2005/006167 patent/WO2005123691A1/en active Application Filing
- 2005-06-08 BR BRPI0512237-6A patent/BRPI0512237A/pt not_active IP Right Cessation
- 2005-06-08 KR KR1020067026563A patent/KR100855929B1/ko not_active IP Right Cessation
- 2005-06-08 MX MXPA06014806A patent/MXPA06014806A/es active IP Right Grant
- 2005-06-08 EP EP05750351A patent/EP1758868A1/en not_active Withdrawn
- 2005-06-08 CA CA002569598A patent/CA2569598A1/en not_active Abandoned
- 2005-06-08 JP JP2007515829A patent/JP4809336B2/ja not_active Expired - Fee Related
- 2005-06-08 SG SG200808461-8A patent/SG148177A1/en unknown
- 2005-06-08 NZ NZ551659A patent/NZ551659A/en unknown
- 2005-06-08 AU AU2005254643A patent/AU2005254643A1/en not_active Abandoned
- 2005-06-15 AR ARP050102451A patent/AR049647A1/es not_active Application Discontinuation
- 2005-07-08 TW TW094119846A patent/TW200637828A/zh unknown
-
2006
- 2006-11-30 IL IL179730A patent/IL179730A0/en unknown
-
2007
- 2007-01-16 NO NO20070295A patent/NO20070295L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL179730A0 (en) | 2007-05-15 |
NZ551659A (en) | 2010-08-27 |
KR20070027590A (ko) | 2007-03-09 |
EP1758868A1 (en) | 2007-03-07 |
BRPI0512237A (pt) | 2008-02-19 |
CA2569598A1 (en) | 2005-12-29 |
SG148177A1 (en) | 2008-12-31 |
WO2005123691A1 (en) | 2005-12-29 |
US20050282803A1 (en) | 2005-12-22 |
AU2005254643A1 (en) | 2005-12-29 |
TW200637828A (en) | 2006-11-01 |
AR049647A1 (es) | 2006-08-23 |
JP4809336B2 (ja) | 2011-11-09 |
JP2008502620A (ja) | 2008-01-31 |
US7893278B2 (en) | 2011-02-22 |
RU2408593C2 (ru) | 2011-01-10 |
MXPA06014806A (es) | 2007-02-12 |
KR100855929B1 (ko) | 2008-09-02 |
RU2007101275A (ru) | 2008-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |