TW200637828A - Novel cis-imidazolines - Google Patents
Novel cis-imidazolinesInfo
- Publication number
- TW200637828A TW200637828A TW094119846A TW94119846A TW200637828A TW 200637828 A TW200637828 A TW 200637828A TW 094119846 A TW094119846 A TW 094119846A TW 94119846 A TW94119846 A TW 94119846A TW 200637828 A TW200637828 A TW 200637828A
- Authority
- TW
- Taiwan
- Prior art keywords
- imidazolines
- compounds
- novel cis
- cis
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58044104P | 2004-06-17 | 2004-06-17 | |
US67419605P | 2005-04-22 | 2005-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200637828A true TW200637828A (en) | 2006-11-01 |
Family
ID=34969621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094119846A TW200637828A (en) | 2004-06-17 | 2005-07-08 | Novel cis-imidazolines |
Country Status (16)
Country | Link |
---|---|
US (1) | US7893278B2 (zh) |
EP (1) | EP1758868A1 (zh) |
JP (1) | JP4809336B2 (zh) |
KR (1) | KR100855929B1 (zh) |
AR (1) | AR049647A1 (zh) |
AU (1) | AU2005254643A1 (zh) |
BR (1) | BRPI0512237A (zh) |
CA (1) | CA2569598A1 (zh) |
IL (1) | IL179730A0 (zh) |
MX (1) | MXPA06014806A (zh) |
NO (1) | NO20070295L (zh) |
NZ (1) | NZ551659A (zh) |
RU (1) | RU2408593C2 (zh) |
SG (1) | SG148177A1 (zh) |
TW (1) | TW200637828A (zh) |
WO (1) | WO2005123691A1 (zh) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1861376A1 (en) * | 2005-03-16 | 2007-12-05 | F. Hoffmann-Roche AG | Cis-2,4,5-triaryl-imidazolines and their use as anti-cancer medicaments |
EP1960368B1 (en) * | 2005-12-01 | 2015-05-06 | F. Hoffmann-La Roche AG | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents |
BRPI0710477A2 (pt) * | 2006-01-18 | 2011-08-16 | Hoffmann La Roche | cis-4, 5- biarila - 2- imidazolinas heterocìclicas como inibidores da mdm2 |
WO2008072655A1 (ja) | 2006-12-14 | 2008-06-19 | Daiichi Sankyo Company, Limited | イミダゾチアゾール誘導体 |
JP5649825B2 (ja) * | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 安定化させたp53ペプチドおよびその使用法 |
KR20160061439A (ko) | 2007-03-28 | 2016-05-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
US7625895B2 (en) * | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
CN101679597B (zh) * | 2007-05-21 | 2015-08-19 | 路博润高级材料公司 | 聚氨酯聚合物 |
JP5559701B2 (ja) * | 2008-01-30 | 2014-07-23 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | イミダゾリウム及びイミダゾリニウム化合物で線維症及び癌を治療する方法 |
EP2271338A4 (en) * | 2008-03-31 | 2011-05-04 | Agency Science Tech & Res | METHOD FOR THE TREATMENT OF NEUROLOGICAL ILLNESSES WITH IMIDAZOLIUM AND IMIDAZOLIUM COMPOUNDS |
EP2298778A4 (en) | 2008-06-12 | 2011-10-05 | Daiichi Sankyo Co Ltd | IMIDAZOTHIAZOL DERIVATIVE WITH 4,7-DIAZASPIRO [2.5] OCTAN RING STRUCTURE |
AU2010205201A1 (en) | 2009-01-16 | 2011-08-04 | Daiichi Sankyo Company,Limited | Imidazothiazole derivative having proline ring structure |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
US8889863B2 (en) | 2010-07-16 | 2014-11-18 | Vanderbilt University | Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds |
KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
ES2685175T3 (es) | 2010-09-30 | 2018-10-05 | St. Jude Children's Research Hospital | Imidazoles sustituidos con arilo |
MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
KR20140100937A (ko) | 2011-10-18 | 2014-08-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
CN104144695A (zh) | 2012-02-15 | 2014-11-12 | 爱勒让治疗公司 | 三唑交联的和硫醚交联的拟肽大环化合物 |
CN107216380A (zh) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | 拟肽大环化合物 |
KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
WO2014134201A1 (en) | 2013-02-28 | 2014-09-04 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
EP2970237B1 (en) | 2013-03-14 | 2017-09-27 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
CA2904870C (en) | 2013-03-15 | 2022-08-23 | Board Of Regents, The University Of Texas System | Inhibition of pulmonary fibrosis with nutlin-3a and peptides |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
EP3294318A4 (en) | 2015-03-20 | 2019-04-03 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF |
WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
MY197785A (en) | 2016-03-15 | 2023-07-13 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for the treatment of hematological malignancies |
BR112018068565A2 (pt) | 2016-03-15 | 2019-02-12 | Oryzon Genomics, S.A. | combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos |
WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
JP6848055B2 (ja) | 2017-06-16 | 2021-03-24 | ユニティ バイオテクノロジー インコーポレイテッド | 薬学的使用のための鏡像異性的に純粋なシス‐イミダゾリン化合物を生成するための合成方法 |
US10588916B2 (en) | 2017-10-31 | 2020-03-17 | Unity Biotechnology, Inc. | Technology to inhibit vascular changes that lead to vision loss in the eye |
JP7204391B2 (ja) * | 2018-09-18 | 2023-01-16 | 株式会社東芝 | 酸性ガス吸収剤、酸性ガスの除去方法及び酸性ガス除去装置 |
KR102622992B1 (ko) * | 2021-03-29 | 2024-01-10 | 주식회사 퓨전바이오텍 | 이미다졸린 유도체 및 이의 중간체 제조방법 |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2441498A (en) * | 1943-07-15 | 1948-05-11 | Astra Apotekarnes Kem Fab | Alkyl glycinanilides |
JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
DE4203547A1 (de) * | 1992-02-07 | 1993-08-12 | Knoll Ag | Verfahren zur racemattrennung von verapamil |
GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
US6653501B2 (en) | 2001-06-27 | 2003-11-25 | Napro Biotherapeutics, Inc. | Chiral resolution method for producing compounds useful in the synthesis of taxanes |
DE60227108D1 (de) | 2001-12-18 | 2008-07-24 | Hoffmann La Roche | Cis-imidazoline als mdm2-hemmer |
RU2305095C2 (ru) | 2001-12-18 | 2007-08-27 | Ф.Хоффманн-Ля Рош Аг | Цис-2,4,5-трифенилимидазолины и фармацевтическая композиция на их основе |
WO2005110996A1 (en) | 2004-05-18 | 2005-11-24 | F.Hoffmann-La Roche Ag | Novel cis-imidazolines |
-
2005
- 2005-06-02 US US11/143,161 patent/US7893278B2/en not_active Expired - Fee Related
- 2005-06-08 NZ NZ551659A patent/NZ551659A/en unknown
- 2005-06-08 EP EP05750351A patent/EP1758868A1/en not_active Withdrawn
- 2005-06-08 KR KR1020067026563A patent/KR100855929B1/ko not_active IP Right Cessation
- 2005-06-08 SG SG200808461-8A patent/SG148177A1/en unknown
- 2005-06-08 BR BRPI0512237-6A patent/BRPI0512237A/pt not_active IP Right Cessation
- 2005-06-08 MX MXPA06014806A patent/MXPA06014806A/es active IP Right Grant
- 2005-06-08 AU AU2005254643A patent/AU2005254643A1/en not_active Abandoned
- 2005-06-08 CA CA002569598A patent/CA2569598A1/en not_active Abandoned
- 2005-06-08 RU RU2007101275/04A patent/RU2408593C2/ru not_active IP Right Cessation
- 2005-06-08 JP JP2007515829A patent/JP4809336B2/ja not_active Expired - Fee Related
- 2005-06-08 WO PCT/EP2005/006167 patent/WO2005123691A1/en active Application Filing
- 2005-06-15 AR ARP050102451A patent/AR049647A1/es not_active Application Discontinuation
- 2005-07-08 TW TW094119846A patent/TW200637828A/zh unknown
-
2006
- 2006-11-30 IL IL179730A patent/IL179730A0/en unknown
-
2007
- 2007-01-16 NO NO20070295A patent/NO20070295L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ551659A (en) | 2010-08-27 |
KR20070027590A (ko) | 2007-03-09 |
US20050282803A1 (en) | 2005-12-22 |
BRPI0512237A (pt) | 2008-02-19 |
IL179730A0 (en) | 2007-05-15 |
WO2005123691A1 (en) | 2005-12-29 |
JP2008502620A (ja) | 2008-01-31 |
MXPA06014806A (es) | 2007-02-12 |
NO20070295L (no) | 2007-01-17 |
AR049647A1 (es) | 2006-08-23 |
RU2408593C2 (ru) | 2011-01-10 |
JP4809336B2 (ja) | 2011-11-09 |
KR100855929B1 (ko) | 2008-09-02 |
AU2005254643A1 (en) | 2005-12-29 |
US7893278B2 (en) | 2011-02-22 |
SG148177A1 (en) | 2008-12-31 |
CA2569598A1 (en) | 2005-12-29 |
EP1758868A1 (en) | 2007-03-07 |
RU2007101275A (ru) | 2008-07-27 |
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