NO20062662L - Muteiner av fibroblast vekstfaktor 21 - Google Patents
Muteiner av fibroblast vekstfaktor 21Info
- Publication number
- NO20062662L NO20062662L NO20062662A NO20062662A NO20062662L NO 20062662 L NO20062662 L NO 20062662L NO 20062662 A NO20062662 A NO 20062662A NO 20062662 A NO20062662 A NO 20062662A NO 20062662 L NO20062662 L NO 20062662L
- Authority
- NO
- Norway
- Prior art keywords
- muteins
- growth factor
- fibroblast growth
- nucleic acid
- morbidity
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title 1
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 208000028399 Critical Illness Diseases 0.000 abstract 1
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000056713 human FGF21 Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52858203P | 2003-12-10 | 2003-12-10 | |
PCT/US2004/037200 WO2005061712A1 (en) | 2003-12-10 | 2004-12-01 | Muteins of fibroblast growth factor 21 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20062662L true NO20062662L (no) | 2006-08-07 |
Family
ID=34710086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20062662A NO20062662L (no) | 2003-12-10 | 2006-06-09 | Muteiner av fibroblast vekstfaktor 21 |
Country Status (14)
Country | Link |
---|---|
US (2) | US7491697B2 (de) |
EP (2) | EP2270163A1 (de) |
JP (1) | JP4477013B2 (de) |
KR (1) | KR20060135648A (de) |
CN (1) | CN1890371A (de) |
AR (1) | AR046877A1 (de) |
AU (1) | AU2004303783A1 (de) |
BR (1) | BRPI0416683A (de) |
CA (1) | CA2549249A1 (de) |
EA (1) | EA200601121A1 (de) |
IL (1) | IL175736A0 (de) |
NO (1) | NO20062662L (de) |
TW (1) | TW200520772A (de) |
WO (1) | WO2005061712A1 (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
US7622445B2 (en) * | 2004-09-02 | 2009-11-24 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
KR100854198B1 (ko) * | 2004-09-02 | 2008-08-26 | 일라이 릴리 앤드 캄파니 | 섬유아세포 성장 인자 21의 뮤테인 |
WO2006065582A2 (en) * | 2004-12-14 | 2006-06-22 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
US20080032343A1 (en) | 2005-12-22 | 2008-02-07 | Genentech, Inc. | Recombinant Production of Heparin Binding Proteins |
ZA200900229B (en) * | 2006-07-14 | 2010-04-28 | Genentech Inc | Refolding of recombinant proteins |
CN104163864B (zh) | 2007-03-30 | 2017-08-01 | Ambrx公司 | 经修饰fgf‑21多肽和其用途 |
KR101530395B1 (ko) | 2007-04-27 | 2015-06-19 | 피페넥스 인크. | 향상된 수율 및(또는) 품질로 이종 단백질을 발현하는 특정 균주를 동정하기 위해 미생물 숙주를 신속히 스크리닝하는 방법 |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
JP2010535781A (ja) * | 2007-08-03 | 2010-11-25 | イーライ リリー アンド カンパニー | 肥満に対する処置 |
US20110015345A1 (en) * | 2008-03-19 | 2011-01-20 | Ambrx, Inc. | Modified FGF-23 Polypeptides and Their Uses |
JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
AU2016203765B2 (en) * | 2008-10-10 | 2017-04-13 | Amgen Inc. | FGF21 mutants and uses thereof |
PE20120021A1 (es) | 2008-10-10 | 2012-02-10 | Amgen Inc | Mutantes fgf21 |
WO2010065439A1 (en) * | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants of fibroblast growth factor 21 |
AU2010207721B2 (en) * | 2009-01-23 | 2015-03-26 | Novo Nordisk A/S | FGF21 derivatives with albumin binder A-B-C-D-E- and their use |
CN107188950B (zh) | 2009-05-05 | 2021-09-28 | 安姆根有限公司 | Fgf21突变体及其用途 |
MX2011011815A (es) | 2009-05-05 | 2012-01-27 | Amgen Inc | Mutantes fgf21 y usos de los mismos. |
JP2012529463A (ja) * | 2009-06-11 | 2012-11-22 | ノヴォ ノルディスク アー/エス | 2型糖尿病を治療するための、glp−1とfgf21との組合せ |
EP2443145A1 (de) * | 2009-06-17 | 2012-04-25 | Amgen, Inc | Chimäre fgf19-polypeptide und ihreverwendung |
EP2679234A3 (de) | 2009-12-02 | 2014-04-23 | Amgen Inc. | Bindeproteine zur Bindung an humanem FGFR1C, humanem beta-Klotho sowie humanem FGFR1C als auch humanem beta-Klotho |
UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
EP2359843A1 (de) | 2010-01-21 | 2011-08-24 | Sanofi | Pharmazeutische Zusammensetzung zur Behandlung eines metabolischen Syndroms |
CA2796055A1 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | Human fgf receptor and .beta.-klotho binding proteins |
US20130116171A1 (en) | 2010-04-16 | 2013-05-09 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf |
EP2595647A1 (de) * | 2010-07-20 | 2013-05-29 | Novo Nordisk A/S | N-terminal-modifizierte fgf21-verbindungen |
WO2012059873A2 (en) * | 2010-11-05 | 2012-05-10 | Covx Technologies Ireland, Ltd. | Anti-diabetic compounds |
US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
WO2012121428A1 (ko) * | 2011-03-07 | 2012-09-13 | 주식회사 웰스킨 | 다이펩타이드를 유효성분으로 포함하는 섬유모세포 증식 조성물 및 상기 조성물을 포함하는 제품 |
US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
EP2548570A1 (de) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmazeutische Zusammensetzung zur Behandlung eines metabolischen Syndroms |
US9006400B2 (en) * | 2011-09-26 | 2015-04-14 | Novartis Ag | Fibroblast growth factor-21-Fc fusion proteins |
US9458214B2 (en) * | 2011-09-26 | 2016-10-04 | Novartis Ag | Dual function fibroblast growth factor 21 proteins |
AR087973A1 (es) | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
EP2793928B1 (de) | 2011-12-22 | 2017-03-15 | Pfizer Inc | Reinigungsverfahren von einer h38c2 antikörperprobe |
WO2013131091A1 (en) | 2012-03-02 | 2013-09-06 | New York University | Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders |
US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
CA2871656A1 (en) | 2012-06-11 | 2013-12-19 | Eli Lilly And Company | Fibroblast growth factor 21 variants |
TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
IL292303A (en) | 2012-12-27 | 2022-06-01 | Ngm Biopharmaceuticals Inc | Methods of regulating bile acid homeostasis and treatment of bile acid disorders and diseases |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
US20160235810A1 (en) | 2013-10-18 | 2016-08-18 | Novartis Ag | Methods of treating diabetes and related disorders |
WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
EP3060238A4 (de) | 2013-10-21 | 2017-06-07 | Salk Institute for Biological Studies | Mutierter fibroblasten-wachstumsfaktor (fgf) 1 und verfahren zur verwendung |
EP3062881B1 (de) | 2013-10-28 | 2019-10-02 | NGM Biopharmaceuticals, Inc. | Krebsmodelle und zugehörige verfahren |
WO2015103782A1 (en) * | 2014-01-13 | 2015-07-16 | Wenzhou Medical College Biological Pharmaceuticals And Nature Products Ltd., Co | Fgf21 mutant and conjugate thereof |
JP6837840B2 (ja) | 2014-01-24 | 2021-03-10 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 結合タンパク質及びその使用方法 |
US20170065678A1 (en) | 2014-03-11 | 2017-03-09 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
EP3155005A4 (de) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Verfahren und verwendungen zur modulierung von gallensäurehomöostase und behandlung von gallensäurestörungen und -erkrankungen |
CN104311656B (zh) * | 2014-10-14 | 2017-04-05 | 哈尔滨博翱生物医药技术开发有限公司 | cFGF‑21蛋白及其在治疗类风湿关节炎中的应用 |
US10517929B2 (en) | 2014-10-23 | 2019-12-31 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising FGF19 variants |
KR20240024362A (ko) | 2014-10-24 | 2024-02-23 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
PL3236991T3 (pl) | 2014-12-23 | 2019-12-31 | Novo Nordisk A/S | Pochodne fgf21 i ich zastosowania |
US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
AU2016344134A1 (en) | 2015-10-30 | 2018-05-31 | Salk Institute For Biological Studies | Treatment of steroid-induced hyperglycemia with fibroblast growth factor (FGF) 1 analogs |
JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
TW201731867A (zh) | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Fgf21變異體 |
WO2017220706A1 (en) * | 2016-06-22 | 2017-12-28 | Novo Nordisk A/S | Pharmaceutical compositions of fgf21 derivatives and uses thereof |
US11370841B2 (en) | 2016-08-26 | 2022-06-28 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
CN108570109B (zh) | 2017-03-14 | 2022-04-26 | 广东东阳光药业有限公司 | 包含免疫球蛋白Fc部分的双靶点融合蛋白 |
WO2018204847A2 (en) * | 2017-05-05 | 2018-11-08 | Trefoil Therapeutics, Inc. | Recombinant modified fibroblast growth factors and therapeutic uses thereof |
US11642395B2 (en) | 2017-09-08 | 2023-05-09 | Bristol-Myers Squibb Company | Modified fibroblast growth factor 21 (FGF-21) for use in methods for treating nonalcoholic steatohepatitis (NASH) |
CN109929806B (zh) | 2017-12-19 | 2020-05-08 | 北京吉源生物科技有限公司 | 一种表达glp1和fgf21的干细胞及其用途 |
WO2019154189A1 (en) | 2018-02-08 | 2019-08-15 | Sunshine Lake Pharma Co., Ltd. | Fgf21 variant, fusion protein and application thereof |
EP3817720A2 (de) | 2018-07-03 | 2021-05-12 | Bristol-Myers Squibb Company | Fgf21-formulierungen |
CN110791517A (zh) * | 2018-08-01 | 2020-02-14 | 中国农业大学 | 成纤维细胞生长因子21的制备、纯化及其结晶 |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
CN111944055B (zh) | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
EP4087612A1 (de) | 2020-01-08 | 2022-11-16 | Bristol-Myers Squibb Company | Fgf-21-konjugatformulierungen |
CN115322794A (zh) | 2020-01-11 | 2022-11-11 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
EP4144375A1 (de) * | 2020-04-29 | 2023-03-08 | Onegene Biotechnology Inc. | Neuartiges proteinkonjugat und verwendung davon zur vorbeugung oder behandlung von nichtalkoholischer steatohepatitis, adipositas und diabetes |
EP4192495A1 (de) | 2020-08-07 | 2023-06-14 | Bristol-Myers Squibb Company | Fgf21 in kombination mit ccr2/5-antagonisten zur behandlung von fibrose |
WO2022115597A1 (en) | 2020-11-25 | 2022-06-02 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
CN113633756A (zh) * | 2021-06-17 | 2021-11-12 | 温州医科大学 | Fgf21温敏缓释载体和基因修饰方法以及其制备方法 |
CN118063586A (zh) * | 2024-04-03 | 2024-05-24 | 独步吾奇生物医疗科技(江苏)有限公司 | 一种人碱性成纤维细胞生长因子的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7408047B1 (en) * | 1999-09-07 | 2008-08-05 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
WO2001018209A1 (en) | 1999-09-10 | 2001-03-15 | Curagen Corporation | Fibroblast growth factor polypeptide and nucleic acids encoding same |
WO2001032678A1 (en) | 1999-11-05 | 2001-05-10 | Smithkline Beecham Corporation | sbgFGF-19a |
ES2335386T3 (es) | 1999-11-18 | 2010-03-26 | Novartis Vaccines And Diagnostics, Inc. | Gen fgf-21 humano y productos de expresion genica. |
US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
WO2001049849A1 (en) | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf11 |
AU5056501A (en) | 2000-03-31 | 2001-10-08 | Nobuyuki Itoh | Fibroblast growth factor-like molecules and uses thereof |
AU2001266765A1 (en) | 2000-06-06 | 2001-12-17 | Incyte Genomics, Inc. | Extracellular messengers |
US20050048507A1 (en) | 2001-01-11 | 2005-03-03 | Mei Zhong | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
AU2002322394A1 (en) * | 2001-07-30 | 2003-02-17 | Eli Lilly And Company | Method for treating diabetes and obesity |
US20050176631A1 (en) | 2002-01-15 | 2005-08-11 | Heuer Josef G. | Method for reducing morbidity and mortality in critically ill patients |
US7495540B2 (en) * | 2004-09-13 | 2009-02-24 | Cooper Technologies Company | Fusible switching disconnect modules and devices |
-
2004
- 2004-12-01 KR KR1020067011358A patent/KR20060135648A/ko not_active Application Discontinuation
- 2004-12-01 EA EA200601121A patent/EA200601121A1/ru unknown
- 2004-12-01 CN CNA200480035794XA patent/CN1890371A/zh active Pending
- 2004-12-01 AU AU2004303783A patent/AU2004303783A1/en not_active Abandoned
- 2004-12-01 US US10/579,510 patent/US7491697B2/en not_active Expired - Fee Related
- 2004-12-01 CA CA002549249A patent/CA2549249A1/en not_active Abandoned
- 2004-12-01 EP EP10184261A patent/EP2270163A1/de not_active Withdrawn
- 2004-12-01 WO PCT/US2004/037200 patent/WO2005061712A1/en active Application Filing
- 2004-12-01 JP JP2006543822A patent/JP4477013B2/ja not_active Expired - Fee Related
- 2004-12-01 EP EP04810531A patent/EP1702067A1/de not_active Withdrawn
- 2004-12-01 BR BRPI0416683-3A patent/BRPI0416683A/pt not_active Application Discontinuation
- 2004-12-09 AR ARP040104584A patent/AR046877A1/es unknown
- 2004-12-10 TW TW093138483A patent/TW200520772A/zh unknown
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2006
- 2006-05-18 IL IL175736A patent/IL175736A0/en unknown
- 2006-06-09 NO NO20062662A patent/NO20062662L/no not_active Application Discontinuation
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2009
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Also Published As
Publication number | Publication date |
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TW200520772A (en) | 2005-07-01 |
CA2549249A1 (en) | 2005-07-07 |
KR20060135648A (ko) | 2006-12-29 |
BRPI0416683A (pt) | 2007-01-30 |
AU2004303783A1 (en) | 2005-07-07 |
IL175736A0 (en) | 2008-02-09 |
US20070142278A1 (en) | 2007-06-21 |
EP2270163A1 (de) | 2011-01-05 |
EA200601121A1 (ru) | 2006-10-27 |
EP1702067A1 (de) | 2006-09-20 |
JP2007535306A (ja) | 2007-12-06 |
CN1890371A (zh) | 2007-01-03 |
WO2005061712A1 (en) | 2005-07-07 |
AR046877A1 (es) | 2005-12-28 |
JP4477013B2 (ja) | 2010-06-09 |
US20090118190A1 (en) | 2009-05-07 |
US7491697B2 (en) | 2009-02-17 |
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