NO20061419L - Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser - Google Patents

Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser

Info

Publication number
NO20061419L
NO20061419L NO20061419A NO20061419A NO20061419L NO 20061419 L NO20061419 L NO 20061419L NO 20061419 A NO20061419 A NO 20061419A NO 20061419 A NO20061419 A NO 20061419A NO 20061419 L NO20061419 L NO 20061419L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
trifluoromethyl
halogen
group
Prior art date
Application number
NO20061419A
Other languages
English (en)
Inventor
Henri Stalder
Emmanuel Pinard
Simona Maria Ceccarelli
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20061419L publication Critical patent/NO20061419L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Oppfinnelsen angår forbindelser med den generelle formel (I) hvor A-A er -CH2-CH2-, -CH2-CH2-CH2-, -CH2-O- eller -O-CH2-; X er hydrogen eller hydroksy; R1 er aryl eller heteroaryl, usubstituert eller substituert med én eller flere substituenter valgt fra gruppen som består av lavere alkyl, lavere alkoksy, halogen eller trifluormetyl; R2 er aryl eller heteroaryl, usubstituert eller substituert med én eller flere substituenter valgt fra gruppen som består av lavere alkyl, lavere alkoksy, halogen eller trifluormetyl, eller er lavere alkyl, -(CH2)n-cykloalkyl, -(CH2)n-CF3, -(CH2)p-O-lavere alkyl, -(CH2)i,2-fenyl, eventuelt substituert med halogen, lavere alkyl, lavere alkoksy eller trifluormetyl, eller er -(CH2)P-NR'R", hvor R' og R" sammen med N-atomet danner en heterocyklisk ring, valgt fra gruppen som består av piperidin, morfolin, tiomorfolin eller 1,1-diokso-tiomorfolin; R3, R4 er uavhengig av hverandre hydrogen, lavere alkyl, fenyl eller benzyl; R5 er hydrogen, lavere alkyl eller benzyl; R6 er hydrogen eller lavere alkyl; n er 0, 1 eller 2; og p er 2 eller 3; og farmasøytisk akseptable syreaddisjonssalter derav for behandling av psykoser, smerte, nevrodegenerativ dysfunksjon relatert til hukommelse og læring, schizofreni, demens og andre sykdommer hvor kognitive prosesser er svekket, så som oppmerksomhetssvikt-lidelser eller Alzheimers sykdom.
NO20061419A 2003-10-23 2006-03-28 Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser NO20061419L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03024415 2003-10-23
PCT/EP2004/011552 WO2005040166A1 (en) 2003-10-23 2004-10-14 Triaza-spiropiperidine derivatives for use as glyt-1 inhibitors in the treatment of neurological and neuropsychiatric disorders

Publications (1)

Publication Number Publication Date
NO20061419L true NO20061419L (no) 2006-07-14

Family

ID=34486099

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061419A NO20061419L (no) 2003-10-23 2006-03-28 Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser

Country Status (19)

Country Link
US (1) US7189850B2 (no)
EP (1) EP1678177B1 (no)
JP (1) JP4490434B2 (no)
KR (1) KR100798161B1 (no)
CN (1) CN100467468C (no)
AR (1) AR046186A1 (no)
AU (1) AU2004283843B2 (no)
BR (1) BRPI0415833A (no)
CA (1) CA2543308C (no)
CO (1) CO5690643A2 (no)
DE (1) DE602004010419T2 (no)
ES (1) ES2297502T3 (no)
IL (1) IL174734A (no)
MX (1) MXPA06004305A (no)
NO (1) NO20061419L (no)
RU (1) RU2006117368A (no)
TW (1) TW200526662A (no)
WO (1) WO2005040166A1 (no)
ZA (1) ZA200603221B (no)

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Also Published As

Publication number Publication date
CO5690643A2 (es) 2006-10-31
TW200526662A (en) 2005-08-16
DE602004010419T2 (de) 2008-10-09
KR20060076317A (ko) 2006-07-04
ES2297502T3 (es) 2008-05-01
DE602004010419D1 (de) 2008-01-10
EP1678177B1 (en) 2007-11-28
IL174734A0 (en) 2006-08-20
KR100798161B1 (ko) 2008-01-28
RU2006117368A (ru) 2007-12-10
US7189850B2 (en) 2007-03-13
AR046186A1 (es) 2005-11-30
MXPA06004305A (es) 2006-06-05
EP1678177A1 (en) 2006-07-12
BRPI0415833A (pt) 2007-01-02
IL174734A (en) 2010-05-31
CN100467468C (zh) 2009-03-11
JP4490434B2 (ja) 2010-06-23
AU2004283843A1 (en) 2005-05-06
AU2004283843B2 (en) 2010-04-22
ZA200603221B (en) 2009-04-29
WO2005040166A1 (en) 2005-05-06
CA2543308C (en) 2012-03-06
CN1871238A (zh) 2006-11-29
US20050107373A1 (en) 2005-05-19
JP2007509097A (ja) 2007-04-12
CA2543308A1 (en) 2005-05-06

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