NO20060975L - 1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoser - Google Patents
1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoserInfo
- Publication number
- NO20060975L NO20060975L NO20060975A NO20060975A NO20060975L NO 20060975 L NO20060975 L NO 20060975L NO 20060975 A NO20060975 A NO 20060975A NO 20060975 A NO20060975 A NO 20060975A NO 20060975 L NO20060975 L NO 20060975L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- halogen
- substituted
- alkoxy
- aryl
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 2
- 239000004471 Glycine Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- VUNXBQRNMNVUMV-UHFFFAOYSA-N phenyl(piperazin-1-yl)methanone Chemical class C=1C=CC=CC=1C(=O)N1CCNCC1 VUNXBQRNMNVUMV-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 150000002367 halogens Chemical group 0.000 abstract 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03019682 | 2003-09-09 | ||
PCT/EP2004/009699 WO2005023261A1 (fr) | 2003-09-09 | 2004-08-31 | Derives de 1-benzoyl-piperazine comme inhibiteurs du recaptage de la glycine pour le traitement de psychoses |
Publications (1)
Publication Number | Publication Date |
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NO20060975L true NO20060975L (no) | 2006-04-06 |
Family
ID=34259148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20060975A NO20060975L (no) | 2003-09-09 | 2006-02-28 | 1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoser |
Country Status (28)
Country | Link |
---|---|
US (1) | US7462617B2 (fr) |
EP (1) | EP1703909B1 (fr) |
JP (1) | JP4563387B2 (fr) |
KR (1) | KR100774621B1 (fr) |
CN (1) | CN100522171C (fr) |
AR (1) | AR045587A1 (fr) |
AT (1) | ATE428424T1 (fr) |
AU (1) | AU2004269892B2 (fr) |
BR (1) | BRPI0413536B8 (fr) |
CA (1) | CA2538135C (fr) |
CO (1) | CO5680430A2 (fr) |
DE (1) | DE602004020674D1 (fr) |
DK (1) | DK1703909T3 (fr) |
ES (1) | ES2322651T3 (fr) |
HK (1) | HK1100483A1 (fr) |
HR (1) | HRP20090265T1 (fr) |
IL (1) | IL174075A (fr) |
MX (1) | MXPA06002672A (fr) |
MY (1) | MY140470A (fr) |
NO (1) | NO20060975L (fr) |
NZ (1) | NZ545613A (fr) |
PL (1) | PL1703909T3 (fr) |
PT (1) | PT1703909E (fr) |
RU (1) | RU2355683C2 (fr) |
SI (1) | SI1703909T1 (fr) |
TW (1) | TW200526601A (fr) |
WO (1) | WO2005023261A1 (fr) |
ZA (1) | ZA200601988B (fr) |
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JP2014521682A (ja) | 2011-08-05 | 2014-08-28 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノクロマン、アミノチオクロマンおよびアミノ−1,2,3,4−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用 |
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US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
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EP3134406A1 (fr) | 2014-04-24 | 2017-03-01 | Dart Neuroscience (Cayman) Ltd | Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c]pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c]pyridine utilisés comme inhibiteurs de glyt1 |
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DE2611705A1 (de) * | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
IT1176613B (it) * | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
PL343435A1 (en) * | 1998-03-06 | 2001-08-13 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
AU2002344951A1 (en) * | 2001-07-02 | 2003-01-21 | Boehringer Ingelheim International Gmbh | Substituted piperazine and diazepanes as histamine h3 receptor agonists |
WO2003035602A1 (fr) * | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
AU2003274053A1 (en) * | 2002-10-22 | 2004-05-13 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
ME00116B (me) * | 2003-08-11 | 2010-10-10 | Hoffmann La Roche | Piperazin sa ili supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1 |
WO2005023260A1 (fr) * | 2003-09-09 | 2005-03-17 | F. Hoffmann-La Roche Ag | Derives de 1-(2-amino-benzol)-piperazine en tant qu'inhibiteurs de l'absorption du glycocolle pour traiter des psychoses |
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- 2004-08-31 RU RU2006111582/04A patent/RU2355683C2/ru not_active IP Right Cessation
- 2004-08-31 PT PT04764664T patent/PT1703909E/pt unknown
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- 2004-08-31 CA CA2538135A patent/CA2538135C/fr not_active Expired - Fee Related
- 2004-08-31 EP EP04764664A patent/EP1703909B1/fr not_active Expired - Lifetime
- 2004-08-31 AU AU2004269892A patent/AU2004269892B2/en not_active Ceased
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- 2004-08-31 KR KR1020067004873A patent/KR100774621B1/ko active IP Right Grant
- 2004-08-31 WO PCT/EP2004/009699 patent/WO2005023261A1/fr active Application Filing
- 2004-08-31 JP JP2006525700A patent/JP4563387B2/ja not_active Expired - Fee Related
- 2004-08-31 CN CNB200480032874XA patent/CN100522171C/zh not_active Expired - Fee Related
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