NO20045235L - Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet - Google Patents

Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet

Info

Publication number
NO20045235L
NO20045235L NO20045235A NO20045235A NO20045235L NO 20045235 L NO20045235 L NO 20045235L NO 20045235 A NO20045235 A NO 20045235A NO 20045235 A NO20045235 A NO 20045235A NO 20045235 L NO20045235 L NO 20045235L
Authority
NO
Norway
Prior art keywords
modulators
chemokine receptor
receptor activity
cyclopentyltetrahydropyridopyridine
tetrahydropyranyl
Prior art date
Application number
NO20045235A
Other languages
English (en)
Norwegian (no)
Inventor
Gregori J Morriello
Lihu Yang
Richard Jiao
Christopher Moyes
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20045235L publication Critical patent/NO20045235L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20045235A 2002-04-29 2004-11-29 Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet NO20045235L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29
PCT/US2003/013042 WO2003093266A1 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
NO20045235L true NO20045235L (no) 2004-11-29

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045235A NO20045235L (no) 2002-04-29 2004-11-29 Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet

Country Status (23)

Country Link
US (1) US7786305B2 (zh)
KR (1) KR100754760B1 (zh)
CN (1) CN1310917C (zh)
AR (1) AR039489A1 (zh)
AU (1) AU2003234251A1 (zh)
BR (1) BR0309650A (zh)
DO (1) DOP2003000638A (zh)
EC (1) ECSP045392A (zh)
HK (1) HK1081967A1 (zh)
HR (1) HRP20041023A2 (zh)
IL (1) IL164909A (zh)
IS (1) IS7512A (zh)
JO (1) JO2479B1 (zh)
MA (1) MA27119A1 (zh)
MX (1) MXPA04010702A (zh)
MY (1) MY129850A (zh)
NO (1) NO20045235L (zh)
PE (1) PE20040598A1 (zh)
PL (1) PL373401A1 (zh)
RU (1) RU2285004C2 (zh)
TW (1) TWI262077B (zh)
UA (1) UA75828C2 (zh)
WO (1) WO2003093266A1 (zh)

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US7576089B2 (en) 2003-12-18 2009-08-18 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
AU2004313486A1 (en) * 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
EP1742919A4 (en) * 2004-04-26 2010-04-28 Merck Sharp & Dohme CYCLOPENTYL TETRAHYDROISOQUINOLINE 1-SUBSTITUTED AND 1,1-DISUBSTITUTED TETRAHYDROPYRANYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
CN101103027A (zh) * 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂
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CN102382088A (zh) 2004-06-28 2012-03-21 因赛特公司 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类
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WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
SI2370442T1 (sl) 2008-11-26 2013-06-28 Pfizer Inc. 3-aminociklopentankarboksiamidi kot modulatorji kemokinskega receptorja
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI471321B (zh) * 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Ｂｃｌ－２族群抑制劑之口服醫藥劑型
SG10201500152UA (en) * 2009-12-22 2015-03-30 Abbvie Inc Abt-263 capsule
RU2598345C2 (ru) 2010-10-29 2016-09-20 Эббви Инк. Твердые дисперсии, содержащие средства, вызывающие апоптоз
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
PT2642999T (pt) 2010-11-23 2017-01-05 Abbvie Ireland Unlimited Co Métodos de tratamento que utilizam inibidores seletivos de bcl-2
BR112013012740A2 (pt) 2010-11-23 2016-09-13 Abbvie Inc sais e formas cristalinas de um agente que induz apoptose
EP2685978A2 (en) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
WO2012125893A1 (en) 2011-03-17 2012-09-20 Bristol-Myers Squibb Company Pyrrolopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
US8822460B2 (en) 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
EP2875023B1 (en) 2012-07-19 2017-04-05 Janssen Pharmaceutica NV Octahydro-cyclopentapyrrolyl antagonists of ccr2
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
SI3297438T1 (sl) 2015-05-21 2022-03-31 Chemocentryx, Inc. CCR2 modulatorji
CA3075638A1 (en) 2017-09-25 2019-03-28 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
WO2019136368A2 (en) 2018-01-08 2019-07-11 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
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JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
DE60322877D1 (de) 2002-04-29 2008-09-25 Merck Sharp & Dohme Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität
EP1501507B1 (en) 2002-04-29 2008-05-28 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004041161A2 (en) 2002-10-30 2004-05-21 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
CN1870998B (zh) 2003-10-27 2010-10-20 默沙东公司 Ccr-2拮抗剂盐
CN101103027A (zh) 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂

Also Published As

Publication number Publication date
CN1662532A (zh) 2005-08-31
UA75828C2 (en) 2006-05-15
ECSP045392A (es) 2005-01-03
WO2003093266A1 (en) 2003-11-13
PL373401A1 (en) 2005-08-22
US20050101628A1 (en) 2005-05-12
AU2003234251A8 (en) 2003-11-17
US7786305B2 (en) 2010-08-31
HK1081967A1 (en) 2006-05-26
DOP2003000638A (es) 2003-11-30
AU2003234251A1 (en) 2003-11-17
MA27119A1 (fr) 2004-12-20
HRP20041023A2 (en) 2005-02-28
CN1310917C (zh) 2007-04-18
IS7512A (is) 2004-10-18
JO2479B1 (en) 2009-01-20
KR20050000413A (ko) 2005-01-03
MXPA04010702A (es) 2005-02-17
RU2285004C2 (ru) 2006-10-10
KR100754760B1 (ko) 2007-09-04
PE20040598A1 (es) 2004-10-05
BR0309650A (pt) 2005-04-26
IL164909A0 (en) 2005-12-18
TW200307543A (en) 2003-12-16
TWI262077B (en) 2006-09-21
IL164909A (en) 2010-04-15
AR039489A1 (es) 2005-02-23
MY129850A (en) 2007-05-31
RU2004134604A (ru) 2005-05-27

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