HRP20041023A2 - Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity - Google Patents

Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity Download PDF

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Publication number
HRP20041023A2
HRP20041023A2 HR20041023A HRP20041023A HRP20041023A2 HR P20041023 A2 HRP20041023 A2 HR P20041023A2 HR 20041023 A HR20041023 A HR 20041023A HR P20041023 A HRP20041023 A HR P20041023A HR P20041023 A2 HRP20041023 A2 HR P20041023A2
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HR
Croatia
Prior art keywords
image
compound
mmol
solution
compounds
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Application number
HR20041023A
Other languages
English (en)
Croatian (hr)
Inventor
Jiao Richard
Morriello Gregori
Yang Lihu
Moyes Christofer
Original Assignee
Merck Sharp & Dohme Limited Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Merck Sharp & Dohme Limited Merck & Co. Inc. filed Critical Merck Sharp & Dohme Limited Merck & Co. Inc.
Publication of HRP20041023A2 publication Critical patent/HRP20041023A2/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20041023A 2002-04-29 2004-10-29 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity HRP20041023A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29
PCT/US2003/013042 WO2003093266A1 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
HRP20041023A2 true HRP20041023A2 (en) 2005-02-28

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20041023A HRP20041023A2 (en) 2002-04-29 2004-10-29 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Country Status (23)

Country Link
US (1) US7786305B2 (zh)
KR (1) KR100754760B1 (zh)
CN (1) CN1310917C (zh)
AR (1) AR039489A1 (zh)
AU (1) AU2003234251A1 (zh)
BR (1) BR0309650A (zh)
DO (1) DOP2003000638A (zh)
EC (1) ECSP045392A (zh)
HK (1) HK1081967A1 (zh)
HR (1) HRP20041023A2 (zh)
IL (1) IL164909A (zh)
IS (1) IS7512A (zh)
JO (1) JO2479B1 (zh)
MA (1) MA27119A1 (zh)
MX (1) MXPA04010702A (zh)
MY (1) MY129850A (zh)
NO (1) NO20045235L (zh)
PE (1) PE20040598A1 (zh)
PL (1) PL373401A1 (zh)
RU (1) RU2285004C2 (zh)
TW (1) TWI262077B (zh)
UA (1) UA75828C2 (zh)
WO (1) WO2003093266A1 (zh)

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JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
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US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
CN1870998B (zh) * 2003-10-27 2010-10-20 默沙东公司 Ccr-2拮抗剂盐
US7576089B2 (en) 2003-12-18 2009-08-18 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
AU2004313486A1 (en) * 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
EP1742919A4 (en) * 2004-04-26 2010-04-28 Merck Sharp & Dohme CYCLOPENTYL TETRAHYDROISOQUINOLINE 1-SUBSTITUTED AND 1,1-DISUBSTITUTED TETRAHYDROPYRANYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
CN101103027A (zh) * 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂
JP2007537264A (ja) 2004-05-11 2007-12-20 インサイト コーポレイション ケモカインレセプタのモジュレータとしての3−(4−ヘテロアリールシクロヘキシルアミノ)シクロペンタンカルボキサミド
CN102382088A (zh) 2004-06-28 2012-03-21 因赛特公司 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类
KR100856156B1 (ko) 2004-06-28 2008-09-03 인사이트 코포레이션 케모카인 수용체의 조절자로서의3-아미노사이클로펜탄카복스아마이드
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
SI2370442T1 (sl) 2008-11-26 2013-06-28 Pfizer Inc. 3-aminociklopentankarboksiamidi kot modulatorji kemokinskega receptorja
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI471321B (zh) * 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Bcl-2族群抑制劑之口服醫藥劑型
SG10201500152UA (en) * 2009-12-22 2015-03-30 Abbvie Inc Abt-263 capsule
RU2598345C2 (ru) 2010-10-29 2016-09-20 Эббви Инк. Твердые дисперсии, содержащие средства, вызывающие апоптоз
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
PT2642999T (pt) 2010-11-23 2017-01-05 Abbvie Ireland Unlimited Co Métodos de tratamento que utilizam inibidores seletivos de bcl-2
BR112013012740A2 (pt) 2010-11-23 2016-09-13 Abbvie Inc sais e formas cristalinas de um agente que induz apoptose
EP2685978A2 (en) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
WO2012125893A1 (en) 2011-03-17 2012-09-20 Bristol-Myers Squibb Company Pyrrolopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
US8822460B2 (en) 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
EP2875023B1 (en) 2012-07-19 2017-04-05 Janssen Pharmaceutica NV Octahydro-cyclopentapyrrolyl antagonists of ccr2
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
SI3297438T1 (sl) 2015-05-21 2022-03-31 Chemocentryx, Inc. CCR2 modulatorji
CA3075638A1 (en) 2017-09-25 2019-03-28 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
WO2019136368A2 (en) 2018-01-08 2019-07-11 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

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US3772308A (en) * 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
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JP2004506013A (ja) * 2000-08-17 2004-02-26 メルク エンド カムパニー インコーポレーテッド シクロペンチル系ケモカイン受容体活性調節剤
EP1368354A1 (en) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulators of chemokine receptor activity
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
DE60322877D1 (de) 2002-04-29 2008-09-25 Merck Sharp & Dohme Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität
EP1501507B1 (en) 2002-04-29 2008-05-28 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004041161A2 (en) 2002-10-30 2004-05-21 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
CN1870998B (zh) 2003-10-27 2010-10-20 默沙东公司 Ccr-2拮抗剂盐
CN101103027A (zh) 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂

Also Published As

Publication number Publication date
CN1662532A (zh) 2005-08-31
UA75828C2 (en) 2006-05-15
ECSP045392A (es) 2005-01-03
WO2003093266A1 (en) 2003-11-13
PL373401A1 (en) 2005-08-22
US20050101628A1 (en) 2005-05-12
AU2003234251A8 (en) 2003-11-17
US7786305B2 (en) 2010-08-31
HK1081967A1 (en) 2006-05-26
DOP2003000638A (es) 2003-11-30
AU2003234251A1 (en) 2003-11-17
MA27119A1 (fr) 2004-12-20
CN1310917C (zh) 2007-04-18
IS7512A (is) 2004-10-18
JO2479B1 (en) 2009-01-20
KR20050000413A (ko) 2005-01-03
MXPA04010702A (es) 2005-02-17
RU2285004C2 (ru) 2006-10-10
KR100754760B1 (ko) 2007-09-04
PE20040598A1 (es) 2004-10-05
NO20045235L (no) 2004-11-29
BR0309650A (pt) 2005-04-26
IL164909A0 (en) 2005-12-18
TW200307543A (en) 2003-12-16
TWI262077B (en) 2006-09-21
IL164909A (en) 2010-04-15
AR039489A1 (es) 2005-02-23
MY129850A (en) 2007-05-31
RU2004134604A (ru) 2005-05-27

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Owner name: MERCK SHARP & DOHME CORP., US

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Payment date: 20110408

Year of fee payment: 9