NO20044332L - Forbedret fremgangsmate for fremstilling av nevirapine - Google Patents
Forbedret fremgangsmate for fremstilling av nevirapineInfo
- Publication number
- NO20044332L NO20044332L NO20044332A NO20044332A NO20044332L NO 20044332 L NO20044332 L NO 20044332L NO 20044332 A NO20044332 A NO 20044332A NO 20044332 A NO20044332 A NO 20044332A NO 20044332 L NO20044332 L NO 20044332L
- Authority
- NO
- Norway
- Prior art keywords
- nevirapine
- preparation
- improved process
- improved
- Prior art date
Links
- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 title 2
- 229960000689 nevirapine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39269002P | 2002-06-28 | 2002-06-28 | |
| PCT/US2003/017376 WO2004002988A1 (en) | 2002-06-28 | 2003-06-02 | Improved method of making nevirapine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20044332L true NO20044332L (no) | 2005-01-17 |
| NO329109B1 NO329109B1 (no) | 2010-08-23 |
Family
ID=30000920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20044332A NO329109B1 (no) | 2002-06-28 | 2004-10-12 | Fremgangsmate for fremstilling av nevirapine samt mellomprodukter |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6680383B1 (no) |
| EP (1) | EP1519936B1 (no) |
| JP (1) | JP4209388B2 (no) |
| KR (1) | KR100981261B1 (no) |
| CN (1) | CN1280293C (no) |
| AR (1) | AR039771A1 (no) |
| AT (1) | ATE382621T1 (no) |
| AU (1) | AU2003237336B2 (no) |
| BR (1) | BR0312071A (no) |
| CA (2) | CA2708442C (no) |
| DE (1) | DE60318444T2 (no) |
| DK (1) | DK1519936T3 (no) |
| EA (1) | EA007497B1 (no) |
| EC (1) | ECSP045514A (no) |
| ES (1) | ES2299709T3 (no) |
| HR (1) | HRP20041214A2 (no) |
| IL (1) | IL163977A0 (no) |
| ME (1) | MEP53908A (no) |
| MX (1) | MXPA04010405A (no) |
| MY (1) | MY131847A (no) |
| NO (1) | NO329109B1 (no) |
| NZ (1) | NZ537803A (no) |
| PE (1) | PE20040586A1 (no) |
| PL (1) | PL371496A1 (no) |
| RS (1) | RS50900B (no) |
| TW (1) | TWI270548B (no) |
| UA (1) | UA80140C2 (no) |
| WO (1) | WO2004002988A1 (no) |
| ZA (1) | ZA200407107B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007010352A1 (en) * | 2005-07-19 | 2007-01-25 | Emcure Pharmaceuticals Limited | An improved process for industrial manufacture of nevirapine |
| JP2007031391A (ja) * | 2005-07-29 | 2007-02-08 | Koei Chem Co Ltd | アルキルアミノピリジンカルボニトリルの製造方法 |
| CN102725293A (zh) * | 2009-12-17 | 2012-10-10 | 西北大学 | 奈韦拉平的多晶型形式及其制备 |
| CN102167699A (zh) * | 2011-03-17 | 2011-08-31 | 湖南博奥德生物医药技术开发有限公司 | 一种奈韦拉平制备方法 |
| WO2012168949A2 (en) * | 2011-06-06 | 2012-12-13 | Laurus Labs Private Limited | A process for preparation of nevirapine |
| CN102321015A (zh) * | 2011-06-30 | 2012-01-18 | 江苏德峰药业有限公司 | 一种抗艾滋病药物奈韦拉平关键中间体 2-(环丙胺基）-3-甲酸吡啶的制备方法 |
| WO2016118586A1 (en) * | 2015-01-20 | 2016-07-28 | Virginia Commonwealth University | Lowcost, high yield synthesis of nevirapine |
| CN116675640A (zh) * | 2023-06-02 | 2023-09-01 | 中科苏州药物研究院 | 一种奈伟拉平中间体2-（环丙基氨基）烟酸的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| DE4403311C1 (de) | 1994-02-03 | 1995-04-20 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on) |
-
2003
- 2003-02-06 UA UAA200500685A patent/UA80140C2/uk unknown
- 2003-06-02 ME MEP-539/08A patent/MEP53908A/xx unknown
- 2003-06-02 CN CNB038105896A patent/CN1280293C/zh not_active Expired - Fee Related
- 2003-06-02 AU AU2003237336A patent/AU2003237336B2/en not_active Ceased
- 2003-06-02 AT AT03736801T patent/ATE382621T1/de active
- 2003-06-02 CA CA2708442A patent/CA2708442C/en not_active Expired - Fee Related
- 2003-06-02 PL PL03371496A patent/PL371496A1/xx not_active IP Right Cessation
- 2003-06-02 CA CA2480046A patent/CA2480046C/en not_active Expired - Fee Related
- 2003-06-02 HR HR20041214A patent/HRP20041214A2/xx not_active Application Discontinuation
- 2003-06-02 MX MXPA04010405A patent/MXPA04010405A/es active IP Right Grant
- 2003-06-02 RS YUP-1102/04A patent/RS50900B/sr unknown
- 2003-06-02 NZ NZ537803A patent/NZ537803A/en not_active IP Right Cessation
- 2003-06-02 KR KR1020047021296A patent/KR100981261B1/ko not_active Expired - Fee Related
- 2003-06-02 WO PCT/US2003/017376 patent/WO2004002988A1/en not_active Ceased
- 2003-06-02 BR BR0312071-6A patent/BR0312071A/pt not_active IP Right Cessation
- 2003-06-02 EP EP03736801A patent/EP1519936B1/en not_active Expired - Lifetime
- 2003-06-02 DE DE60318444T patent/DE60318444T2/de not_active Expired - Lifetime
- 2003-06-02 ES ES03736801T patent/ES2299709T3/es not_active Expired - Lifetime
- 2003-06-02 JP JP2004517609A patent/JP4209388B2/ja not_active Expired - Fee Related
- 2003-06-02 EA EA200401535A patent/EA007497B1/ru not_active IP Right Cessation
- 2003-06-02 DK DK03736801T patent/DK1519936T3/da active
- 2003-06-02 IL IL16397703A patent/IL163977A0/xx not_active IP Right Cessation
- 2003-06-05 US US10/454,991 patent/US6680383B1/en not_active Expired - Lifetime
- 2003-06-26 PE PE2003000642A patent/PE20040586A1/es not_active Application Discontinuation
- 2003-06-27 AR ARP030102323A patent/AR039771A1/es unknown
- 2003-06-27 TW TW092117662A patent/TWI270548B/zh not_active IP Right Cessation
- 2003-06-27 MY MYPI20032417A patent/MY131847A/en unknown
-
2004
- 2004-09-06 ZA ZA200407107A patent/ZA200407107B/en unknown
- 2004-10-12 NO NO20044332A patent/NO329109B1/no not_active IP Right Cessation
- 2004-12-27 EC EC2004005514A patent/ECSP045514A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |