PE20040586A1 - Procedimiento para preparar nevirapina - Google Patents
Procedimiento para preparar nevirapinaInfo
- Publication number
- PE20040586A1 PE20040586A1 PE2003000642A PE2003000642A PE20040586A1 PE 20040586 A1 PE20040586 A1 PE 20040586A1 PE 2003000642 A PE2003000642 A PE 2003000642A PE 2003000642 A PE2003000642 A PE 2003000642A PE 20040586 A1 PE20040586 A1 PE 20040586A1
- Authority
- PE
- Peru
- Prior art keywords
- cyclopropylamine
- nevirapine
- halo
- prepare
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR NEVIRAPINA EN LAS SIGUIENTES ETAPAS: A) HACER RECCIONAR UN 2-HALO-3-PIRIDINOCARBONITRILO CON CICLOPROPILAMINA PARA PROPORCIONAR 2-(CICLOPROPILAMINO)-3-PIRIDINCARBONITRILO (1); B) HIDROLIZAR (1) PARA PROPORCIONAR ACIDO 2-(CICLOPROPILAMINO)-3-PIRIDINA-CARBOXILICO (2); C) AISLAR (2) A PARTIR DEL MEDIO DE REACCION; D) TRATAR (2) CON UN AGENTE COLORANTE PARA PROPORCIONAR CLORURO DE 2-(CICLOPROPILAMINO)-3-PIRIDINCARBONILO (3); E) HACER REACCIONAR (3) CON UNA 2-HALO-4-METIL-3-PIRIDINAMINA PARA PRODUCIR N-(2-HALO-4-METIL-3-PIRIDINIL)-2-(CICLOPROPILAMINO)-3-PIRIDINCARBOXAMIDA (4); F) CICLAR (4) MEDIANTE TRATAMIENTO CON UNA BASE FUERTE PARA PROPORCIONAR NEVIRAPINA. DICHA SINTESIS PROPORCIONA MAYOR RENDIMIENTO, MAYOR SEGURIDAD Y ES MAS ECONOMICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39269002P | 2002-06-28 | 2002-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040586A1 true PE20040586A1 (es) | 2004-11-04 |
Family
ID=30000920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000642A PE20040586A1 (es) | 2002-06-28 | 2003-06-26 | Procedimiento para preparar nevirapina |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6680383B1 (es) |
| EP (1) | EP1519936B1 (es) |
| JP (1) | JP4209388B2 (es) |
| KR (1) | KR100981261B1 (es) |
| CN (1) | CN1280293C (es) |
| AR (1) | AR039771A1 (es) |
| AT (1) | ATE382621T1 (es) |
| AU (1) | AU2003237336B2 (es) |
| BR (1) | BR0312071A (es) |
| CA (2) | CA2480046C (es) |
| DE (1) | DE60318444T2 (es) |
| DK (1) | DK1519936T3 (es) |
| EA (1) | EA007497B1 (es) |
| EC (1) | ECSP045514A (es) |
| ES (1) | ES2299709T3 (es) |
| HK (1) | HK1080848A1 (es) |
| HR (1) | HRP20041214A2 (es) |
| IL (1) | IL163977A0 (es) |
| ME (1) | MEP53908A (es) |
| MX (1) | MXPA04010405A (es) |
| MY (1) | MY131847A (es) |
| NO (1) | NO329109B1 (es) |
| NZ (1) | NZ537803A (es) |
| PE (1) | PE20040586A1 (es) |
| PL (1) | PL371496A1 (es) |
| RS (1) | RS50900B (es) |
| TW (1) | TWI270548B (es) |
| UA (1) | UA80140C2 (es) |
| WO (1) | WO2004002988A1 (es) |
| ZA (1) | ZA200407107B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007010352A1 (en) * | 2005-07-19 | 2007-01-25 | Emcure Pharmaceuticals Limited | An improved process for industrial manufacture of nevirapine |
| JP2007031391A (ja) * | 2005-07-29 | 2007-02-08 | Koei Chem Co Ltd | アルキルアミノピリジンカルボニトリルの製造方法 |
| BR112012014762A2 (pt) * | 2009-12-17 | 2016-03-29 | Univ Northwest | forma polimorfa de nevirapina e sua preparação |
| CN102167699A (zh) * | 2011-03-17 | 2011-08-31 | 湖南博奥德生物医药技术开发有限公司 | 一种奈韦拉平制备方法 |
| WO2012168949A2 (en) * | 2011-06-06 | 2012-12-13 | Laurus Labs Private Limited | A process for preparation of nevirapine |
| CN102321015A (zh) * | 2011-06-30 | 2012-01-18 | 江苏德峰药业有限公司 | 一种抗艾滋病药物奈韦拉平关键中间体 2-(环丙胺基）-3-甲酸吡啶的制备方法 |
| WO2016118586A1 (en) * | 2015-01-20 | 2016-07-28 | Virginia Commonwealth University | Lowcost, high yield synthesis of nevirapine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| DE4403311C1 (de) * | 1994-02-03 | 1995-04-20 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on) |
-
2003
- 2003-02-06 UA UAA200500685A patent/UA80140C2/uk unknown
- 2003-06-02 RS YUP-1102/04A patent/RS50900B/sr unknown
- 2003-06-02 ES ES03736801T patent/ES2299709T3/es not_active Expired - Lifetime
- 2003-06-02 NZ NZ537803A patent/NZ537803A/en not_active IP Right Cessation
- 2003-06-02 CA CA2480046A patent/CA2480046C/en not_active Expired - Fee Related
- 2003-06-02 DE DE60318444T patent/DE60318444T2/de not_active Expired - Lifetime
- 2003-06-02 PL PL03371496A patent/PL371496A1/xx not_active IP Right Cessation
- 2003-06-02 KR KR1020047021296A patent/KR100981261B1/ko not_active IP Right Cessation
- 2003-06-02 MX MXPA04010405A patent/MXPA04010405A/es active IP Right Grant
- 2003-06-02 CN CNB038105896A patent/CN1280293C/zh not_active Expired - Fee Related
- 2003-06-02 BR BR0312071-6A patent/BR0312071A/pt not_active IP Right Cessation
- 2003-06-02 DK DK03736801T patent/DK1519936T3/da active
- 2003-06-02 EP EP03736801A patent/EP1519936B1/en not_active Expired - Lifetime
- 2003-06-02 IL IL16397703A patent/IL163977A0/xx not_active IP Right Cessation
- 2003-06-02 ME MEP-539/08A patent/MEP53908A/xx unknown
- 2003-06-02 WO PCT/US2003/017376 patent/WO2004002988A1/en active IP Right Grant
- 2003-06-02 JP JP2004517609A patent/JP4209388B2/ja not_active Expired - Fee Related
- 2003-06-02 AT AT03736801T patent/ATE382621T1/de active
- 2003-06-02 AU AU2003237336A patent/AU2003237336B2/en not_active Ceased
- 2003-06-02 EA EA200401535A patent/EA007497B1/ru not_active IP Right Cessation
- 2003-06-02 CA CA2708442A patent/CA2708442C/en not_active Expired - Fee Related
- 2003-06-05 US US10/454,991 patent/US6680383B1/en not_active Expired - Lifetime
- 2003-06-26 PE PE2003000642A patent/PE20040586A1/es not_active Application Discontinuation
- 2003-06-27 TW TW092117662A patent/TWI270548B/zh not_active IP Right Cessation
- 2003-06-27 AR ARP030102323A patent/AR039771A1/es unknown
- 2003-06-27 MY MYPI20032417A patent/MY131847A/en unknown
-
2004
- 2004-09-06 ZA ZA200407107A patent/ZA200407107B/en unknown
- 2004-10-12 NO NO20044332A patent/NO329109B1/no not_active IP Right Cessation
- 2004-12-27 EC EC2004005514A patent/ECSP045514A/es unknown
- 2004-12-27 HR HR20041214A patent/HRP20041214A2/xx not_active Application Discontinuation
-
2006
- 2006-01-18 HK HK06100817A patent/HK1080848A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0117084A (pt) | Aparelho para melhorar sintomas de acne de uma região de pele | |
| DE60144064D1 (de) | Sulfone, die die aktivität von gamma-secretase modulieren | |
| CY1117292T1 (el) | Τοπικη συνθεση φροντιδας του δερματος | |
| CY1118171T1 (el) | Θεραπευτικη αντιμετωπιση της φαiνυλκετονουρiας me βη4 | |
| BR0313282A (pt) | Composições de inibidor seletivo de ciclooxigenase-2 e um inibidor de anidrase carbÈnica para o tratamento de neoplasia | |
| ATE442124T1 (de) | Sebum- und schweissabsorbierendes grundierungsset und entsprechendes mehrstufiges verfahren | |
| TR201821337T4 (tr) | Yüzeysel insan dokusunun kontrollü termal tedavisi için sistem. | |
| BRPI0510925A (pt) | métodos e composições para cicatrização de ferida | |
| NO20035743D0 (no) | Substituerte oksazolindinoner for kombinasjonsterapi | |
| HK1085140A1 (en) | Pharmaceutical compositions and method of using levodopa and carbidopa | |
| CY1109229T1 (el) | Χρηση σπογγοσινης (2-μεθοξυαδενοσινης) για τη θεραπεια πονου, συγκεκριμενα υπερευαισθησιας στο πονο | |
| NO20055741L (no) | Nye kjemiske forbindelser | |
| ATE462424T1 (de) | Therapeutische anwendung von zerstäubtem s- nitrosoglutathion bei zystischer fibrose | |
| WO2004054432A3 (en) | Methods and devices for therapeutic treatment cardiac and other pathologies | |
| NO20045214L (no) | Cyklotiokarbamatderivater som BR modulatorere og anvendelse derav for behandling av hudlidelser | |
| PL370795A1 (en) | Composition based on etyllinoleate and triethylcitrate for the treatment of seborrhea and acne | |
| PE20040586A1 (es) | Procedimiento para preparar nevirapina | |
| NO20063308L (no) | Kombinasjon av flupirtin og tramadol | |
| CY1109666T1 (el) | Μεθοδος θεραπειας διαταραχων ξηροφθαλμιας και ραγοειδιτιδας | |
| DE60229235D1 (de) | D kupfersulfaten und sucralphat | |
| ATE337005T1 (de) | Nagellack enthaltend tazaroten und verwendung dessen zur behandlung und/oder zur prävention von psoriasis | |
| BR0312260A (pt) | Dispositivos para tratamento terapêutico e para emissão de luz | |
| MXPA05004121A (es) | Metodos para tratar la enfermedad de ojo reseco con lantibioticos. | |
| WO2022092907A3 (ko) | 다부위에 적용가능한 플라즈마 치료기 | |
| ITMI20030661A1 (it) | Processo per la preparazione della ferutinina da piante del genere ferula |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |